CXOTalk
CXOTalk

CXOTalk

Michael Krigsman

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C-Suite Conversations on AI & Strategy. Join industry analyst Michael Krigsman for unfiltered discussions with the leaders shaping the future of business. From AI implementation to digital transformation, hear directly from CIOs, CTOs, CEOs, and more from the world's largest companies. No scripts. No PR fluff. Just real questions from our live audience and honest answers from the C-Suite. Want to participate? Get invited to the next live show: https://www.cxotalk.com/subscribe

Recent Episodes

The Cardiovascular System, Mapped in Code as a Digital Twin | CXOTalk #901
DEC 9, 2025
The Cardiovascular System, Mapped in Code as a Digital Twin | CXOTalk #901

Can a digital replica of your heart save your life? In CXOTalk episode 902, Michael Krigsman talks with Dr. Joe Alexander, Director of the Medical and Health Informatics Lab at NTT Research, to explore the revolutionary world of Bio-Digital Twins.Discover how researchers are using mathematical modeling to build "computational replicas" of the human cardiovascular system. Dr. Alexander explains how these digital twins can predict heart failure, automate critical care in the ICU through closed-loop intervention systems, and pave the way for a future where personalized medicine is accessible to everyone.We dive deep into the science of treating the heart as an electrical circuit, the ethics of AI in medicine, and the "moonshot" goal of eliminating cardiovascular disease..๐Ÿ”ท Show notes: https://www.cxotalk.com/episode/cardiac-digital-twins-inside-the-research-lab๐Ÿ”ท Newsletter: www.cxotalk.com/subscribe๐Ÿ”ท LinkedIn: www.linkedin.com/company/cxotalk๐Ÿ”ท Twitter: twitter.com/cxotalk๐Ÿ’ก KEY TOPICS DISCUSSED:Bio-Digital Twins: How digital replicas of organs allow doctors to test treatments virtually before applying them physically.Closed-Loop Systems: The development of autonomous systems that can regulate heart medication beat-by-beat to minimize oxygen consumption and improve recovery.The Physics of the Heart: How Dr. Alexander uses resistors, capacitors, and diodes to model blood flow and pressure.The Future of MedTech: Moving from acute care (ICU) to managing chronic heart failure with wearable technology.๐Ÿ‘ฅ ABOUT THE GUEST:


Dr. Joe Alexander is the Director of the Medical and Health Informatics Lab at NTT Research. With a unique background as a chemical engineer and a burn survivor who later attended Johns Hopkins for his MD/PhD, Dr. Alexander is leading "moonshot" research into bio-digital twins to transform cardiovascular care.๐Ÿ“ CHAPTERS:0:00 - Introduction: What is a Cardiac Digital Twin? 2:20 - The Aviation Analogy: Predictive Maintenance for the Body 4:54 - The "Electrical Analog" Model: Viewing the Heart as a Circuit 6:42 - Autonomous Closed-Loop Intervention: Automating ICU Care 12:04 - How a Digital Twin is Built (Population vs. Patient Data) 17:09 - Animal Trials & Validating the Technology 22:11 - Ethics & Safety: Can We Trust AI with Life-and-Death Decisions? 29:03 - Causal vs. Black Box AI: Why Physiology Matters 44:58 - The "Bionic" Approach: Interdisciplinary Teams 50:32 - Health Equity & The Quintuple Aims of Healthcare#DigitalTwins #Cardiology #MedTech #AIinHealthcare #NTTResearch #FutureOfMedicine #HeartHealth #CXOTalk

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54 MIN
How AI Changed a 150-Year-Old Industrial Manufacturing Company! | CXOTalk #901
NOV 24, 2025
How AI Changed a 150-Year-Old Industrial Manufacturing Company! | CXOTalk #901

How do you turn a 150-year-old industrial giant into an agile, AI-first organization?

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Please support our sponsor Emeritus:

Explore executive education programs from Emeritus, in collaboration with top universities: https://cxotalk.partner.emeritus.org/

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For Hexion CEO Michael Lefenfeld, the answer isn't just about technology, but about culture, safety, and rethinking value. In episode 901 of CXOTalk, Lefenfeld details his strategy for integrating AI across every level of a billion-dollar manufacturing enterprise, from the R&D lab to the factory floor.

Michael Krigsman and Michael Lefenfeld discuss the practical realities of moving beyond "pilot purgatory." They dive into how to manage workforce anxiety (the "carrot vs. stick" approach), leverage Private Equity for long-term innovation, and maintain strict safety guardrails while moving fast.

If you are a leader navigating the complexities of digital transformation, this interview offers a concrete roadmap for driving growth without sacrificing your company's heritage.


๐Ÿ“‹ DISCUSSION TOPICS:

-- The AI-First Culture: Why Hexion incentivizes AI adoption rather than forcing it.

-- Workforce Strategy: How to upskill employees and ensure AI is a "partner," not a "job taker."

-- Operational Excellence: Using AI to achieve the "Golden Batch"โ€”reducing waste and energy usage.

-- The Private Equity Advantage: How ownership structure impacts long-term tech investment.

-- Strategic Partnerships: Using data to deepen customer intimacy and escape the commodity trap.


โฑ๏ธ TIMESTAMPS

00:00 ๐Ÿญ Introduction to Hexion and Its Role in Everyday Life

01:28 ๐Ÿค– Hexion's Integration of AI Across Operations

03:34 ๐Ÿš€ AI as a Tool for Growth and Empowerment at Hexion

13:47 ๐Ÿค– Leadership Philosophy and AI Integration at Hexion

16:44 ๐Ÿ›ก๏ธ AI's Role in Safety and Decision-Making

20:25 โš™๏ธ AI-Driven Efficiency and Learning in Manufacturing

26:54 ๐Ÿ’‰ Personal Experience with Diabetes and Continuous Glucose Monitoring

28:30 ๐Ÿค– AI's Role in Customer Service and Business Operations

32:53 ๐ŸŒ AI Learning, Ecosystem Collaboration, and Organizational Growth

38:32 ๐Ÿค– Using AI to Enhance Manufacturing and Investment Decisions

40:04 ๐Ÿข Hexion's AI-First Strategy and Customer-Centric Approach

46:32 ๐Ÿ’ผ Private Equity's Role in AI Investment and Long-Term Growth

50:20 ๐Ÿงช Optimizing Products with Data and Batch Chemistry

51:44 ๐Ÿค– AI's Impact on Business Models and Lessons Learned

53:30 ๐Ÿš€ Advice for AI Implementation and Closing Remarks


๐ŸŽฏ FEATURED GUEST

Michael Lefenfeld is the CEO of Hexion Inc. and a serial entrepreneur with a passion for revitalizing legacy industries.

-- He holds 100+ patents and was named a World Economic Forum Young Global Leader.

-- Michael specializes in bridging the gap between deep science (chemistry/physics) and practical business strategy (AI/profitability).

-- Previously served as CEO of Cyanco and SiGNa Chemistry.


๐Ÿ“š RESOURCES

๐Ÿ”ท Show notes:https://www.cxotalk.com/episode/ai-first-rewiring-a-150-year-old-industrial-manufacturer

๐Ÿ”ท Newsletter: www.cxotalk.com/subscribe

๐Ÿ”ท LinkedIn: www.linkedin.com/company/cxotalk

๐Ÿ”ท Twitter: twitter.com/cxotalk Subscribe to CXOTalk newsletter: https://www.cxotalk.com/newsletter


๐ŸŽ™๏ธ ABOUT CXOTALK

CXOTalk features unfiltered conversations with C-suite executives from major companies about AI, digital transformation, and business strategy. Hosted by Michael Krigsman. Episode 901 | Recorded November 21, 2025

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55 MIN
Why Your AI Strategy Is Failing: Fortune 500 CEO Advisor Explains | CXOTalk #900
NOV 17, 2025
Why Your AI Strategy Is Failing: Fortune 500 CEO Advisor Explains | CXOTalk #900

๐Ÿšจ STOP treating AI like just another automation tool; you're missing the real transformation.

 

Most executives are approaching AI completely wrong. They're focused on automating tasks when they should be reimagining their entire business model. In this landmark 900th episode of CXOTalk, Sangeet Paul Choudary, advisor to 40+ Fortune 500 CEOs, reveals why AI is actually COORDINATION INFRASTRUCTURE, not just a productivity tool.

 

You'll discover:

โœ… Why the "automation mindset" guarantees you'll fall behind competitors

โœ… The shipping container parable that explains AI's true strategic impact

โœ… How to think about AI strategy (hint: it's NOT about "what to do with AI")

โœ… The dangerous myth of "AI augmentation" and what actually happens to jobs

โœ… Real examples: How TikTok's logic revolutionized manufacturing (Shein)

โœ… Above vs. below the algorithm: Where YOU fit in the new economy

โœ… The word processor paradox—why complementarity doesn't save jobs

โœ… Strategic foresight: The #1 capability leaders must develop NOW

 

This isn't theoretical. Sangeet breaks down exactly how businesses must reimagine their competitive advantage, how professionals should navigate career decisions, and why yesterday's AI vendors are selling you 1990s solutions.

 

โฑ๏ธ TIMESTAMPS

 

00:00 ๐Ÿค– Rethinking AI Beyond Automation

01:10 ๐Ÿ“ˆ AI's Strategic Role in Business Transformation

03:33 ๐Ÿšข Lessons from the Shipping Container and AI's Potential

08:22 ๐Ÿ”ฎ The Importance of Foresight in Career and Organizational Planning

11:16 ๐Ÿค– Automation, Augmentation, and the Changing Division of Labor

14:08 ๐Ÿ“ˆ Adapting to Shifting Value in the Age of AI

19:04 ๐Ÿค– The Role of CXOs in the Age of AI

22:50 ๐Ÿข Indicators of Organizational Shift with AI

26:00 ๐Ÿ’ก Lessons Between Startups and Legacy Companies in AI Strategy

31:11 ๐Ÿ“ฑ TikTok's Influence on Manufacturing and Shein's Success

33:58 ๐Ÿค– Challenges in Implementing AI and System Redesign

36:05 ๐ŸŒ Socio-Technical Systems and Strategic Shifts with AI

38:50 ๐Ÿงช AI's Impact on the Materials Industry

41:03 ๐Ÿค– Strategic Application of AI in Industries

42:52 ๐ŸŒ AI's Role in Ecosystems and Job Dynamics

49:23 โš™๏ธ The Role of Risk and Constraints in Value Creation

50:51 ๐Ÿค– AI's Impact on Knowledge Work and Career Advice

55:41 ๐Ÿ“Š Advice for Companies and Policymakers in the Age of AI

 

๐ŸŽฏ FEATURED GUEST

Sangeet Paul Choudary

  • Advisor to 40+ Fortune 500 CEOs
  • Author of "Reshuffle: The New Business Playbook for a World Transformed by AI"
  • Expert on platform business models and digital transformation

 

๐Ÿ“š RESOURCES

๐Ÿ”ท Show notes: https://www.cxotalk.com/episode/why-ai-works-but-your-strategy-doesnt

๐Ÿ”ท Newsletter: www.cxotalk.com/subscribe

๐Ÿ”ท LinkedIn: www.linkedin.com/company/cxotalk

๐Ÿ”ท Twitter: twitter.com/cxotalk Subscribe to CXOTalk newsletter: https://www.cxotalk.com/newsletter

 

๐ŸŽ™๏ธ ABOUT CXOTALK

CXOTalk features unfiltered conversations with C-suite executives from major companies about AI, digital transformation, and business strategy. Hosted by Michael Krigsman.

Episode 900 | Recorded November 14, 2025

 

#AI #AIStrategy #DigitalTransformation #BusinessStrategy #CEOInsights #FutureOfWork #Leadership #AITransformation #Reshuffle #CXOTalk

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58 MIN
Big Tech's AI Oligopoly: Lords Reveal the Power Grab | CXOTalk 899
NOV 4, 2025
Big Tech's AI Oligopoly: Lords Reveal the Power Grab | CXOTalk 899

Microsoft invested $13 billion in OpenAI. Amazon poured billions into Anthropic. The AI oligopoly is here. Lord Tim Clement-Jones and Lord Chris Holmes, architects of UK AI policy, reveal what business leaders must know about Big Tech's grip on AI - from vendor lock-in risks to circular funding patterns signaling bubble collapse.

 

๐Ÿ”ท Show notes and resources: https://www.cxotalk.com/episode/house-of-lords-members-on-ai-does-big-tech-own-you

๐Ÿ”ท Newsletter: www.cxotalk.com/subscribe

๐Ÿ”ท LinkedIn: www.linkedin.com/company/cxotalk

๐Ÿ”ท Twitter: twitter.com/cxotalk

 

๐ŸŽฏ KEY TAKEAWAYS:

 

-- Why AI concentration mirrors 19th century monopolies

-- The regulation vs innovation false choice

-- Vendor dependencies creating strategic vulnerabilities

-- UK vs EU vs US regulatory approaches

-- Copyright battles over training data

-- Board-level AI governance essentials

 

โฑ๏ธ TIMESTAMPS:

 

00:00 ๐Ÿค– The AI Oligopoly and Big Tech's Influence

02:27 ๐ŸŒ Opportunities and Risks of AI Development

09:03 โš–๏ธ Regulation and the Future of AI

12:43 ๐Ÿ’ป The Risks of Overdependence on Big Tech

15:33 ๐Ÿง  The Importance of Media and Digital Literacy

17:55 ๐ŸŒ Human Values in Technology and Education

21:25 ๐Ÿ“š Education and Regulation in the Digital Age

24:36 ๐ŸŒˆ Optimism and Diversity in Technology

27:13 โš ๏ธ Dependency and Vulnerability in Technology

29:58 ๐Ÿค– Navigating AI's Impact on Employment and Society

34:46 ๐Ÿ›๏ธ The Role of Government and Lifelong Learning in the AI Era

39:16 โš–๏ธ Challenges of AI Transparency and Regulation

43:07 โš–๏ธ The Importance of AI Regulation and Transparency

45:00 ๐ŸŒ Open Source and Diverse AI Models

52:18 โš™๏ธ Balancing Regulation and Innovation in AI

55:04 ๐Ÿ’ฐ Economic Interdependence in AI Development

55:48 ๐Ÿ“ˆ Advice for Business Leaders in the AI Era

56:54 โš–๏ธ Guidance for Regulators and Policymakers on AI

 

๐Ÿ’ก ABOUT CXOTALK:

 

CXOTalk connects you with the world's most innovative business leaders, senior executives, and experts sharing insights on digital transformation, leadership, and innovation. Every episode brings you actionable strategies from those leading change in their organizations.

 

#ArtificialIntelligence #AITransformation #monopoly #bigtech #cxotalk #houseoflords #inclusion #aiethics

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59 MIN
CIO Advice on AI: How Chief Information Officers Can Lead in 2025 | CXOTalk #898
OCT 21, 2025
CIO Advice on AI: How Chief Information Officers Can Lead in 2025 | CXOTalk #898

Is your organization stuck in AI pilot purgatory? CIO strategic advisor Tim Crawford reveals how enterprise AI is fundamentally transforming the CIO role, and why the decisions you make today will determine which IT leaders succeed tomorrow.

 

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Please support our sponsor Emeritus:

Explore executive education programs from Emeritus, in collaboration with top universities: https://cxotalk.partner.emeritus.org/

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In CXOTalk episode 898, Tim breaks down the massive multi-dimensional impact AI is having on CIOs: from daily operations and decision-making to board-level relationships and business transformation. You'll discover why efficiency gains are just the beginning, and how strategic CIOs are leveraging AI to drive real business outcomes—not just run technology projects.

 

๐Ÿ”— RESOURCES:

 

๐Ÿ”ท Show notes and resources: https://www.cxotalk.com/episode/the-cios-new-mandate-enterprise-ai

๐Ÿ”ท Newsletter: www.cxotalk.com/subscribe

๐Ÿ”ท LinkedIn: www.linkedin.com/company/cxotalk

๐Ÿ”ท Twitter: twitter.com/cxotalk

 

๐ŸŽฏ KEY TAKEAWAYS:

 

- How AI is changing the CIO's day-to-day responsibilities and strategic influence

- Why 75% of AI projects fail to prove ROI (and how to avoid this trap)

- The critical difference between efficiency plays and transformational innovation

- Why change management is now the CIO's #1 responsibility for AI success

- The truth about Chief AI Officer roles vs. strategic CIO positioning

- How to escape AI pilot purgatory and achieve measurable business outcomes

 

โฑ๏ธ TIMESTAMPS:

 

00:00 ๐Ÿค– The Role of AI in Transforming the CIO's Responsibilities

05:40 ๐Ÿš€ Overcoming AI Pilot Purgatory and Achieving Business Outcomes

11:20 ๐ŸŒ Navigating the AI Hype and Embracing Innovation

12:21 ๐Ÿค– Adapting Business Operations for AI Integration

13:20 ๐Ÿ“Š Measuring AI Value and Business Outcomes

22:35 ๐Ÿ”’ Security and Governance in AI Implementation

24:07 ๐Ÿค– Challenges in AI Governance and Data Management

26:03 ๐Ÿ’ผ AI's Impact on Business Processes and Workforce

28:58 ๐ŸŒ Sustainability, Partnerships, and AI Proof of Concept Challenges

35:16 โš–๏ธ Balancing Business Objectives and AI Project Success

38:39 ๐Ÿค The Importance of Relationships and Process Understanding

43:56 ๐Ÿค– AI Ownership, Decision-Making, and Vendor Relationships

46:26 ๐Ÿค Strategic Use of External Partners in Organizations

49:33 ๐Ÿค– The Role of AI in the C-Suite

51:16 ๐Ÿ“… Closing Remarks and Upcoming Events

 

๐Ÿ’ก ABOUT CXOTALK:

 

CXOTalk connects you with the world's most innovative business leaders, senior executives, and experts sharing insights on digital transformation, leadership, and innovation. Every episode brings you actionable strategies from those leading change in their organizations.

 

#CIO #ArtificialIntelligence #AITransformation #DigitalTransformation #ITLeadership #BusinessStrategy #EnterpriseAI #TechnologyLeadership #CXOTalk #ExecutiveLeadership #AIStrategy #ChangeManagement #Innovation #BusinessOutcomes

 

๐Ÿ‘ If you found this valuable, please LIKE and SHARE with your network.

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52 MIN