San Francisco 49ers battle major injuries and locker room drama as they visit the Indianapolis Colts on Monday Night Football. Can Kyle Shanahan’s resilient squad overcome the loss of Brandon Aiyuk and push for the NFC’s top seed? The Colts, powered by Philip Rivers’ surprising return, look to capitalize on their renewed fighting spirit after nearly upsetting the Seattle Seahawks. Trench warfare between the 49ers’ defensive line and Colts’ protective front. Spotlighting Christian McCaffrey’s multi-threat role, and examine how injuries to stars like Mooney Ward, DeForest Buckner, and Sauce Gardner impact the game plan. Special teams, coaching strategy, and the ability to force mistakes in a high-stakes playoff race are put under the microscope. Will either side seize control and keep their postseason hopes alive? Don’t miss this essential breakdown of a pivotal Week 16 showdown. San Francisco 49ers fans are treated to daily news and analysis with Locked On 49ers, hosted by football analyst Brian Peacock and former NFL/AFL cornerback Eric Crocker. Follow & Subscribe on all Podcast platforms…🎧 https://link.chtbl.com/LO49ers?sid=YouTube Locked On NFL League-Wide: Every Team, Fantasy, Draft & More🎧 https://linktr.ee/LockedOnNFL Follow Brian Peacock and Eric Crocker on Twitter, where they’ll be sharing the latest news about the Niners and talking with fans.Twitter: twitter.com/BDPeacock, twitter.com/eric_crocker Everydayer Club  If you never miss an episode, it’s time to make it official. Join the Locked On Everydayer Club and get ad-free audio, access to our members-only Discord, and more — all built for our most loyal fans. Click here to learn more and join your team’s community: https://lockedonpodcasts.com/everydayerclub   Support Us By Supporting Our Sponsors!   Rocket MoneyTake control of your finances and cancel your unwanted subscriptions with Rocket Money.Go to https://RocketMoney.com/LOCKEDON today. Aura FramesFor a limited time, save on the perfect gift by visiting https://AuraFrames.com to get $35 off Aura’s best-selling Carver Mat frames - named #1 by Wirecutter - by using promo code LOCKEDON at checkout. FanDuelIf you want to be right in the middle of the action this season, visit FanDuel.com and place your NFL live bets all season long. PrizePicksDownload the PrizePicks app today and use code LOCKEDONNFL to get $50 in lineups after you play your first $5 lineup.Click Here: https://prizepicks.onelink.me/LME0/LOCKEDONNFL GametimeDownload the Gametime app, create an account, and use code LOCKEDONNFL for $20 off your first purchase. Terms apply. Download Gametime today. What time is it? Gametime. FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN) Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.