<description>&lt;p&gt;In his weekly clinical update, Dr. Griffin informs us about the World Health Organization research and development plan to combat endemic pathogens including hepatitis C virus, RSV and dengue virus, another case of mpox in Britian, the Marburg virus outbreak in Rwanda, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, if there is a benefit to additional COVID vaccinations after the initial series, ISDA guideline for using anti-SARS-CoV-2 monoclonal antibody therapy for prophylaxis, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, if and how do severe secondary bacterial infections develop following SARS-CoV-2 infection, and if COVID-19 associates with a risk of autoimmune and autoinflammatory connective tissue disorders.&lt;/p&gt; &lt;p&gt;Subscribe (free): &lt;a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"&gt; &lt;strong&gt;Apple Podcasts&lt;/strong&gt;&lt;/a&gt;, &lt;a href= "http://twiv.microbeworld.libsynpro.com/twiv"&gt;&lt;strong&gt;RSS&lt;/strong&gt;&lt;/a&gt;, &lt;a href="http://eepurl.com/Gcw59"&gt;&lt;strong&gt;email&lt;/strong&gt;&lt;/a&gt;&lt;/p&gt; &lt;p&gt;Become a &lt;a href= "https://www.microbe.tv/contribute"&gt;&lt;strong&gt;patron&lt;/strong&gt;&lt;/a&gt; of TWiV!&lt;/p&gt; &lt;h3 id="links-for-this-episode" class="wp-block-heading"&gt; &lt;strong&gt;Links for this episode&lt;/strong&gt;&lt;/h3&gt; &lt;ul class="wp-block-list"&gt; &lt;li&gt;Is the WHO the world’s NIH: endemic &lt;a href= "https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(24)00460-2/fulltext"&gt;&lt;strong&gt;pathogens&lt;/strong&gt;&lt;/a&gt; initiative (eBioMedicine)&lt;/li&gt; &lt;li&gt;Another two cases of mpox in &lt;a href= "https://www.reuters.com/world/uk/uk-detects-two-more-cases-new-mpox-variant-2024-11-04/"&gt;&lt;strong&gt;Britian&lt;/strong&gt;&lt;/a&gt; (Reuters)&lt;/li&gt; &lt;li&gt;How to &lt;a href="https://rbc.gov.rw/"&gt;&lt;strong&gt;stop Marburg&lt;/strong&gt;&lt;strong&gt; virus&lt;/strong&gt;&lt;/a&gt; (Rwanda Biomedical Centre)&lt;/li&gt; &lt;li&gt;Marburg Virus &lt;a href= "https://rbc.gov.rw/marburg/"&gt;&lt;strong&gt;fact sheet&lt;/strong&gt;&lt;/a&gt; (Rwanda Biomedical Centre)&lt;/li&gt; &lt;li&gt;Influenza weekly surveillance report: &lt;a href= "https://www.cdc.gov/fluview/surveillance/2024-week-37.html"&gt;&lt;strong&gt;cliff notes&lt;/strong&gt;&lt;/a&gt; (CDC FluView)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://www.cdc.gov/rsv/php/surveillance/rsv-net.html"&gt;&lt;strong&gt;RSV&lt;/strong&gt;&lt;/a&gt; NETwork (CDC RSV)&lt;/li&gt; &lt;li&gt;Respiratory virus &lt;a href= "https://www.cdc.gov/respiratory-viruses/data/activity-levels.html"&gt;&lt;strong&gt;activity&lt;/strong&gt;&lt;/a&gt; (CDC Respiratory Illnesses)&lt;/li&gt; &lt;li&gt;COVID-19 &lt;a href= "https://covid.cdc.gov/covid-data-tracker/#maps_percent-covid-deaths"&gt;&lt;strong&gt;deaths&lt;/strong&gt;&lt;/a&gt; (CDC)&lt;/li&gt; &lt;li&gt;COVID-19 &lt;a href= "https://www.cdc.gov/nwss/rv/COVID19-nationaltrend.html"&gt;&lt;strong&gt;national and regional&lt;/strong&gt;&lt;/a&gt; trends (CDC)&lt;/li&gt; &lt;li&gt;Waste water scan for &lt;a href= "https://data.wastewaterscan.org/?charts=CjIQACABSABaBk4gR2VuZXIKMjAyNC0wOC0wN3IKMjAyNC0wOS0xOIoBBmQ0MzllMsABAQ%3D%3D&amp;selectedChartId=d439e2"&gt;&lt;strong&gt;11 pathogens&lt;/strong&gt;&lt;/a&gt; (WastewaterSCan)&lt;/li&gt; &lt;li&gt;COVID-19 &lt;a href= "https://covid.cdc.gov/covid-data-tracker/index.html#variant-proportions"&gt;&lt;strong&gt;variant tracker&lt;/strong&gt;&lt;/a&gt; (CDC)&lt;/li&gt; &lt;li&gt;SARS-CoV-2 &lt;a href= "https://nextstrain.org/ncov/gisaid/global/all-time?d=tree,frequencies&amp;p=full&amp;r=division&amp;showBranchLabels=all&amp;tl=none"&gt;&lt;strong&gt;genomes&lt;/strong&gt;&lt;/a&gt; galore (Nextstrain)&lt;/li&gt; &lt;li&gt;Symptom reduction after&lt;a href= "https://academic.oup.com/ofid/article/11/10/ofae545/7774470"&gt;&lt;strong&gt; additional&lt;/strong&gt;&lt;/a&gt; vaccine dose during Omicron (OFID)&lt;/li&gt; &lt;li&gt;IDSA Guideline update for SARS-CoV-2 monoclonal antibody &lt;a href= "https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciae435/7849632?utm_source=advanceaccess&amp;utm_campaign=cid&amp;utm_medium=email&amp;nbd=40427954633&amp;nbd_source=campaigner"&gt;&lt;strong&gt;pemivibart&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt; &lt;/strong&gt;pre-exposure prophylaxis (CID)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://www.pemgarda.com/hcp/infusion-center-locator/"&gt;&lt;strong&gt;Where&lt;/strong&gt;&lt;/a&gt; to get pemgarda (Pemgarda)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://investors.adagiotx.com/news-releases/news-release-details/invivyd-announces-fda-authorization-emergency-use-pemgardatm"&gt; &lt;strong&gt;EUA&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt; &lt;/strong&gt;for the pre-exposure prophylaxis of COVID-19 (INVIYD)&lt;/li&gt; &lt;li&gt;Fusion &lt;a href= "https://primeinfusions.com/locations/"&gt;&lt;strong&gt;center&lt;/strong&gt;&lt;/a&gt; near you….if in NY (Prime Fusions)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://www.cdc.gov/respiratory-viruses/guidance/faqs.html?CDC_AAref_Val=https://www.cdc.gov/respiratory-viruses/guidance/faq.html"&gt; &lt;strong&gt;CDC Quarantine&lt;/strong&gt;&lt;/a&gt; guidelines (CDC)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://www.ncbi.nlm.nih.gov/books/NBK570371/"&gt;&lt;strong&gt;NIH&lt;/strong&gt;&lt;/a&gt; COVID-19 treatment guidelines (NIH)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://www.idsociety.org/practice-guideline/covid-19-guideline-treatment-and-management/#ExecutiveSummaryandBackground"&gt; &lt;strong&gt;Infectious Disease Society guidelines&lt;/strong&gt;&lt;/a&gt; for treatment and management (ID Society)&lt;/li&gt; &lt;li&gt;Drug interaction &lt;a href= "https://covid19-druginteractions.org/checker"&gt;&lt;strong&gt;checker&lt;/strong&gt;&lt;/a&gt; (University of Liverpool)&lt;/li&gt; &lt;li&gt;Molnupiravir &lt;a href= "https://onlinelibrary.wiley.com/doi/10.1002/jmv.28011"&gt;&lt;strong&gt;safety&lt;/strong&gt;&lt;/a&gt; and efficacy (JMV)&lt;/li&gt; &lt;li&gt;Convalescent plasma recommendation for &lt;a href= "https://www.idsociety.org/practice-guideline/covid-19-guideline-treatment-and-management/"&gt;&lt;strong&gt;immunocompromised&lt;/strong&gt;&lt;/a&gt; (ID Society)&lt;/li&gt; &lt;li&gt;What to do when sick with a &lt;a href= "https://www.cdc.gov/ncird/whats-new/updated-respiratory-virus-guidance.html"&gt;&lt;strong&gt;respiratory virus&lt;/strong&gt;&lt;/a&gt; (CDC)&lt;/li&gt; &lt;li&gt;When your healthcare provider is &lt;a href= "https://www.cdc.gov/covid/hcp/infection-control/guidance-risk-assesment-hcp.html?CDC_AAref_Val=https://www.cdc.gov/coronavirus/2019-ncov/hcp/guidance-risk-assesment-hcp.html"&gt;&lt;strong&gt;infected/exposed&lt;/strong&gt;&lt;/a&gt; with SARS-CoV-2 (CDC)&lt;/li&gt; &lt;li&gt;Managing healthcare staffing &lt;a href= "https://www.cdc.gov/covid/hcp/infection-control/mitigating-staff-shortages.html?CDC_AAref_Val=https://www.cdc.gov/coronavirus/2019-ncov/hcp/mitigating-staff-shortages.html"&gt;&lt;strong&gt;shortages&lt;/strong&gt;&lt;/a&gt; (CDC)&lt;/li&gt; &lt;li&gt;Steroids, &lt;a href= "https://academic.oup.com/ofid/article/10/3/ofad105/7055978"&gt;&lt;strong&gt;dexamethasone&lt;/strong&gt;&lt;/a&gt; at the right time (OFID)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://www.hematology.org/education/clinicians/guidelines-and-quality-care/clinical-practice-guidelines/venous-thromboembolism-guidelines/ash-guidelines-on-use-of-anticoagulation-in-patients-with-covid-19"&gt; &lt;strong&gt;Anticoagulation&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt;&lt;u&gt; &lt;/u&gt;&lt;/strong&gt;guidelines (hematology.org)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://www.nature.com/articles/s41467-024-53566-x"&gt;&lt;strong&gt;Secondary&lt;/strong&gt;&lt;/a&gt; bacterial infection follows COVID-19 (Nature Communications)&lt;/li&gt; &lt;li&gt;Daniel Griffin’s &lt;a href= "https://academic.oup.com/ofid/article/11/9/ofae462/7733485"&gt;&lt;strong&gt;evidence-based&lt;/strong&gt;&lt;/a&gt; medical practices for long COVID (OFID)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://jamanetwork.com/journals/jamadermatology/article-abstract/2825849"&gt; &lt;strong&gt;Autoimmune and autoinflammatory&lt;/strong&gt;&lt;/a&gt; connective tissue disorders following COVID-19 (JAMA Dermatology)&lt;/li&gt; &lt;li&gt;&lt;strong&gt;&lt;a title="" href= "https://www.microbe.tv/twiv/twiv-1164-letters/"&gt;Letters read&lt;/a&gt;&lt;/strong&gt; on TWiV 1164&lt;/li&gt; &lt;li&gt;Dr. Griffin’s COVID treatment summary (&lt;a title="" href= "https://twiv.s3.amazonaws.com/COVID+treatment+summary+032224.pdf"&gt;&lt;strong&gt;pdf&lt;/strong&gt;&lt;/a&gt;)&lt;/li&gt; &lt;li&gt;Timestamps by &lt;a href= "https://ramseylab.vercel.app/"&gt;&lt;strong&gt;Jolene&lt;/strong&gt;&lt;/a&gt;. Thanks!&lt;/li&gt; &lt;/ul&gt; &lt;p&gt;Intro music is by &lt;a href= "http://www.ronaldjenkees.com/"&gt;&lt;strong&gt;Ronald Jenkees&lt;/strong&gt;&lt;/a&gt;&lt;/p&gt; &lt;p&gt;Send your questions for Dr. Griffin to daniel@microbe.tv&lt;/p&gt;</description>

This Week in Virology

Vincent Racaniello

TWiV 1164: Clinical update with Dr. Daniel Griffin

NOV 9, 202440 MIN
This Week in Virology

TWiV 1164: Clinical update with Dr. Daniel Griffin

NOV 9, 202440 MIN

Description

In his weekly clinical update, Dr. Griffin informs us about the World Health Organization research and development plan to combat endemic pathogens including hepatitis C virus, RSV and dengue virus, another case of mpox in Britian, the Marburg virus outbreak in Rwanda, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, if there is a benefit to additional COVID vaccinations after the initial series, ISDA guideline for using anti-SARS-CoV-2 monoclonal antibody therapy for prophylaxis, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, if and how do severe secondary bacterial infections develop following SARS-CoV-2 infection, and if COVID-19 associates with a risk of autoimmune and autoinflammatory connective tissue disorders.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]