<description>&lt;p&gt;In his weekly clinical update, Dr. Griffin deep dives into whether the mysterious respiratory illness in the Congo is malaria, and in conjunction with your host Vincent Racaniello discusses the failure of the poliovirus eradication campaign with virus circulation detected throughout Europe and how we should focus on disease control not virus circulation, then returns to discussing avian influenza in raw milk and the early stoppage of the mpox antiviral Tecovirimat  before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, if there is a difference in protection against the development of severe disease between an mRNA or a protein based vaccine, where to find PEMGARDA, and information for Columbia Unversity Irving Medical Center’s long COVID treatment center.&lt;/p&gt; &lt;div class="fluid-width-video-wrapper"&gt;Subscribe (free): &lt;a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"&gt;&lt;strong&gt;Apple Podcasts&lt;/strong&gt;&lt;/a&gt;, &lt;a href= "http://twiv.microbeworld.libsynpro.com/twiv"&gt;&lt;strong&gt;RSS&lt;/strong&gt;&lt;/a&gt;, &lt;a href="http://eepurl.com/Gcw59"&gt;&lt;strong&gt;email&lt;/strong&gt;&lt;/a&gt;&lt;/div&gt; &lt;p&gt;Become a &lt;a href= "https://www.microbe.tv/contribute"&gt;&lt;strong&gt;patron&lt;/strong&gt;&lt;/a&gt; of TWiV!&lt;/p&gt; &lt;h3 id="links-for-this-episode" class="wp-block-heading"&gt; &lt;strong&gt;Links for this episode&lt;/strong&gt;&lt;/h3&gt; &lt;ul class="wp-block-list"&gt; &lt;li&gt;IIs the &lt;a href= "https://apnews.com/article/mystery-disease-congo-malaria-who-c772403273a89b5dcdc86778ad7eeed3"&gt;mysterious disease&lt;/a&gt; in the Congo, malaria? (AP News)&lt;/li&gt; &lt;li&gt;State of &lt;a href= "https://apnews.com/article/mystery-disease-congo-malaria-who-c772403273a89b5dcdc86778ad7eeed3"&gt;global health&lt;/a&gt;, year-end remarks by WHO director-general (WHO)&lt;/li&gt; &lt;li&gt;Really, progress towards poliomyelitis eradication&lt;a href= "https://www.cdc.gov/mmwr/volumes/73/wr/mm7349a4.htm?s_cid=mm7349a4_e&amp;ACSTrackingID=USCDC_921-DM141852&amp;ACSTrackingLabel=This%20Week%20in%20MMWR%3A%20Vol.%2073%2C%20December%2012%2C%202024&amp;deliveryName=USCDC_921-DM141852"&gt;&lt;strong&gt;?&lt;/strong&gt;&lt;/a&gt; (CDC MMWR)&lt;/li&gt; &lt;li&gt;Increases in confirm &lt;a href= "https://www.who.int/news/item/03-12-2024-statement-of-the-fortieth-meeting-of-the-polio-ihr-emergency-committee"&gt;&lt;strong&gt;cases &lt;/strong&gt;&lt;strong&gt;¹&lt;/strong&gt;&lt;strong&gt; control&lt;/strong&gt;&lt;/a&gt; of poliomyelitis (WHO)&lt;/li&gt; &lt;li&gt;Polio European Union and United Kingdom, is that 1 &lt;strong&gt;&lt;a href= "https://www.science.org/content/article/poliovirus-keeps-popping-european-wastewater-perplexing-and-worrying-scientists"&gt;global entry&lt;/a&gt;&lt;/strong&gt;? (Science)&lt;/li&gt; &lt;li&gt;Is the WHO the global CDC?  &lt;a href= "https://www.who.int/teams/immunization-vaccines-and-biologicals/diseases/poliomyelitis-(polio)#:~:text=Inactivated%20polio%20vaccine%20(IPV)%20%E2%80%93,poliovirus%20types%201%2C%20and%203"&gt;&lt;strong&gt;polio vaccination guidelines&lt;/strong&gt;&lt;/a&gt; (WHO)&lt;/li&gt; &lt;li&gt;Do you feed &lt;a href= "http://publichealth.lacounty.gov/phcommon/public/media/mediapubhpdetail.cfm?prid=4901"&gt;&lt;strong&gt;your cats raw milk&lt;/strong&gt;&lt;/a&gt;? (Public Health LA county)&lt;/li&gt; &lt;li&gt;Is there avian influenza in the &lt;a href= "https://www.maricopa.gov/CivicAlerts.aspx?AID=3149"&gt;&lt;strong&gt;zoo&lt;/strong&gt;&lt;/a&gt; near you? (Maricopa)&lt;/li&gt; &lt;li&gt;Don’t &lt;a href= "https://www.cidrap.umn.edu/avian-influenza-bird-flu/avian-flu-suspected-cats-drank-raw-milk-virus-kills-animals-arizona-zoo"&gt;&lt;strong&gt;feed&lt;/strong&gt;&lt;/a&gt; your cat raw milk (CIDRAP)&lt;/li&gt; &lt;li&gt;&lt;a href="https://www.microbe.tv/twiv/twiv-1173/"&gt;&lt;strong&gt;Holy Cow!&lt;/strong&gt;&lt;/a&gt; H5N1 in cows! (microbeTV)&lt;/li&gt; &lt;li&gt;Tecovirimat &lt;a href= "https://www.niaid.nih.gov/news-events/nih-study-finds-tecovirimat-was-safe-did-not-improve-mpox-resolution-or-pain"&gt;&lt;strong&gt;no improvement&lt;/strong&gt;&lt;/a&gt; in Mpox resolution or pain(NIAID NIH)&lt;/li&gt; &lt;li&gt;Interim results from &lt;a href= "https://investor.siga.com/investors/news/news-details/2024/Interim-Results-from-STOMP-Study-of-SIGAs-Tecovirimat-in-Treatment-of-Mpox-Announced/default.aspx"&gt;&lt;strong&gt;STOMP&lt;/strong&gt;&lt;/a&gt; study of  Tecovirimat (SIGA&lt;strong&gt;)&lt;/strong&gt;&lt;/li&gt; &lt;li&gt;Trial stops enrollment after Tpoxx &lt;a href= "https://www.cidrap.umn.edu/mpox/trial-stops-enrollment-after-tpoxx-fails-speed-clade-2-mpox-healing-or-pain-relief"&gt;&lt;strong&gt;fails&lt;/strong&gt;&lt;/a&gt; (CIDRAP)&lt;/li&gt; &lt;li&gt;Is Tecovirimat really &lt;a href= "https://www.mdpi.com/1999-4915/14/9/1870"&gt;&lt;strong&gt;first-in-class&lt;/strong&gt;&lt;/a&gt; mpox therapy? (Viruses)&lt;/li&gt; &lt;li&gt;Influenza weekly surveillance report: &lt;a href= "https://www.cdc.gov/fluview/surveillance/2024-week-37.html"&gt;&lt;strong&gt;clift notes&lt;/strong&gt;&lt;/a&gt; (CDC FluView)&lt;/li&gt; &lt;li&gt;US &lt;a href= "https://www.cdc.gov/respiratory-viruses/data/activity-levels.html"&gt;&lt;strong&gt;respiratory&lt;/strong&gt;&lt;/a&gt; virus activity (CDC Respiratory Illnesses)&lt;/li&gt; &lt;li&gt;Waste water scan for &lt;a href= "https://data.wastewaterscan.org/?charts=CjIQACABSABaBk4gR2VuZXIKMjAyNC0wOC0wN3IKMjAyNC0wOS0xOIoBBmQ0MzllMsABAQ%3D%3D&amp;selectedChartId=d439e2"&gt;&lt;strong&gt;11 pathogens&lt;/strong&gt;&lt;/a&gt; (WastewaterSCan)&lt;/li&gt; &lt;li&gt;RSV-&lt;a href= "https://www.cdc.gov/rsv/php/surveillance/rsv-net.html"&gt;&lt;strong&gt;Net&lt;/strong&gt;&lt;/a&gt;work (CDC Respiratory Syncytial virus Infection)&lt;/li&gt; &lt;li&gt;COVID-19 &lt;a href= "https://covid.cdc.gov/covid-data-tracker/#maps_percent-covid-deaths"&gt;&lt;strong&gt;deaths&lt;/strong&gt;&lt;/a&gt; (CDC)&lt;/li&gt; &lt;li&gt;COVID-19 &lt;a href= "https://www.cdc.gov/nwss/rv/COVID19-nationaltrend.html"&gt;&lt;strong&gt;national and regional&lt;/strong&gt;&lt;/a&gt; trends (CDC)&lt;/li&gt; &lt;li&gt;Waste water scan for &lt;a href= "https://data.wastewaterscan.org/?charts=CjIQACABSABaBk4gR2VuZXIKMjAyNC0wOC0wN3IKMjAyNC0wOS0xOIoBBmQ0MzllMsABAQ%3D%3D&amp;selectedChartId=d439e2"&gt;&lt;strong&gt;11 pathogens&lt;/strong&gt;&lt;/a&gt; (WastewaterSCan)&lt;/li&gt; &lt;li&gt;COVID-19 &lt;a href= "https://covid.cdc.gov/covid-data-tracker/index.html#variant-proportions"&gt;&lt;strong&gt;variant tracker&lt;/strong&gt;&lt;/a&gt; (CDC)&lt;/li&gt; &lt;li&gt;SARS-CoV-2 &lt;a href= "https://nextstrain.org/ncov/gisaid/global/all-time?d=tree,frequencies&amp;p=full&amp;r=division&amp;showBranchLabels=all&amp;tl=none"&gt;&lt;strong&gt;genomes&lt;/strong&gt;&lt;/a&gt; galore (Nextstrain)&lt;/li&gt; &lt;li&gt;Relative effectiveness of homologous &lt;a href= "https://www.sciencedirect.com/science/article/pii/S0264410X2401185X?via%3Dihub"&gt;&lt;strong&gt;NVX-CoV2373 and BNT162b2&lt;/strong&gt;&lt;/a&gt; COVID-19 vaccinations in South Korea (Vaccine)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-023-08754-3"&gt; &lt;strong&gt;Phase III trial&lt;/strong&gt;&lt;/a&gt; results! Comparative efficacy and safety of COVID-19 (BMC Infectious Diseases)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://www.pemgarda.com/hcp/infusion-center-locator/"&gt;&lt;strong&gt;Where&lt;/strong&gt;&lt;/a&gt; to get pemgarda (Pemgarda)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://investors.adagiotx.com/news-releases/news-release-details/invivyd-announces-fda-authorization-emergency-use-pemgardatm"&gt; &lt;strong&gt;EUA&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt; &lt;/strong&gt;for the pre-exposure prophylaxis of COVID-19 (INVIYD)&lt;/li&gt; &lt;li&gt;Fusion &lt;a href= "https://primeinfusions.com/locations/"&gt;&lt;strong&gt;center&lt;/strong&gt;&lt;/a&gt; near you….if in NY (Prime Fusions)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://www.cdc.gov/respiratory-viruses/guidance/faqs.html?CDC_AAref_Val=https://www.cdc.gov/respiratory-viruses/guidance/faq.html"&gt; &lt;strong&gt;CDC Quarantine&lt;/strong&gt;&lt;/a&gt; guidelines (CDC)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://www.ncbi.nlm.nih.gov/books/NBK570371/"&gt;&lt;strong&gt;NIH&lt;/strong&gt;&lt;/a&gt; COVID-19 treatment guidelines (NIH)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://www.idsociety.org/practice-guideline/covid-19-guideline-treatment-and-management/#ExecutiveSummaryandBackground"&gt; &lt;strong&gt;Infectious Disease Society guidelines&lt;/strong&gt;&lt;/a&gt; for treatment and management (ID Society)&lt;/li&gt; &lt;li&gt;Drug interaction &lt;a href= "https://covid19-druginteractions.org/checker"&gt;&lt;strong&gt;checker&lt;/strong&gt;&lt;/a&gt; (University of Liverpool)&lt;/li&gt; &lt;li&gt;Molnupiravir &lt;a href= "https://onlinelibrary.wiley.com/doi/10.1002/jmv.28011"&gt;&lt;strong&gt;safety&lt;/strong&gt;&lt;/a&gt; and efficacy (JMV)&lt;/li&gt; &lt;li&gt;Convalescent plasma recommendation for &lt;a href= "https://www.idsociety.org/practice-guideline/covid-19-guideline-treatment-and-management/"&gt;&lt;strong&gt;immunocompromised&lt;/strong&gt;&lt;/a&gt; (ID Society)&lt;/li&gt; &lt;li&gt;What to do when sick with a &lt;a href= "https://www.cdc.gov/ncird/whats-new/updated-respiratory-virus-guidance.html"&gt;&lt;strong&gt;respiratory virus&lt;/strong&gt;&lt;/a&gt; (CDC)&lt;/li&gt; &lt;li&gt;When your healthcare provider is &lt;a href= "https://www.cdc.gov/covid/hcp/infection-control/guidance-risk-assesment-hcp.html?CDC_AAref_Val=https://www.cdc.gov/coronavirus/2019-ncov/hcp/guidance-risk-assesment-hcp.html"&gt;&lt;strong&gt;infected/exposed&lt;/strong&gt;&lt;/a&gt; with SARS-CoV-2 (CDC)&lt;/li&gt; &lt;li&gt;Managing healthcare staffing &lt;a href= "https://www.cdc.gov/covid/hcp/infection-control/mitigating-staff-shortages.html?CDC_AAref_Val=https://www.cdc.gov/coronavirus/2019-ncov/hcp/mitigating-staff-shortages.html"&gt;&lt;strong&gt;shortages&lt;/strong&gt;&lt;/a&gt; (CDC)&lt;/li&gt; &lt;li&gt;Stop playing &lt;a href= "https://www.cambridge.org/core/journals/infection-control-and-hospital-epidemiology/article/respiratory-equality-lets-stop-playing-favorites-with-covid19-in-the-healthcare-setting/1DEFCBC8C3BB4698FC4F79951990A7B8?utm_source=SFMC&amp;utm_medium=email&amp;utm_content=Article&amp;utm_campaign=New%20Cambridge%20Alert%20-%20Articles&amp;WT.mc_id=New%20Cambridge%20Alert%20-%20Articles"&gt;&lt;strong&gt;favorites&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt; &lt;/strong&gt;with COVID-19 in healthcare settings (Infection Control &amp; Hospital Epidemiology)&lt;/li&gt; &lt;li&gt;Steroids, &lt;a href= "https://academic.oup.com/ofid/article/10/3/ofad105/7055978"&gt;&lt;strong&gt;dexamethasone&lt;/strong&gt;&lt;/a&gt; at the right time (OFID)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://www.hematology.org/education/clinicians/guidelines-and-quality-care/clinical-practice-guidelines/venous-thromboembolism-guidelines/ash-guidelines-on-use-of-anticoagulation-in-patients-with-covid-19"&gt; &lt;strong&gt;Anticoagulation&lt;/strong&gt;&lt;/a&gt; guidelines (hematology.org)&lt;/li&gt; &lt;li&gt;Remdesivir Effectiveness in Reducing the Risk of &lt;a href= "https://www.netflix.com/watch/70217198?trackId=155573560"&gt;&lt;strong&gt;30-day Readmission&lt;/strong&gt;&lt;/a&gt; in Vulnerable Patients Hospitalized for COVID-19 (CID)&lt;/li&gt; &lt;li&gt;Daniel Griffin’s &lt;a href= "https://academic.oup.com/ofid/article/11/9/ofae462/7733485"&gt;&lt;strong&gt;evidence based&lt;/strong&gt;&lt;/a&gt; medical practices for long COVID (OFID)&lt;/li&gt; &lt;li&gt;Long COVID &lt;a href= "https://www.columbiadoctors.org/health-library/article/long-covid/"&gt;&lt;strong&gt;hotline&lt;/strong&gt;&lt;/a&gt; (Columbia : Columbia University Irving Medical Center)&lt;/li&gt; &lt;li&gt;&lt;strong&gt;&lt;a title="" href= "https://www.microbe.tv/twiv/twiv-1174-letters/"&gt;Letters read&lt;/a&gt; &lt;/strong&gt;on TWiV 1174&lt;/li&gt; &lt;li&gt;Dr. Griffin’s COVID treatment summary (&lt;a title="" href= "https://twiv.s3.amazonaws.com/COVID+treatment+summary+032224.pdf"&gt;&lt;strong&gt;pdf&lt;/strong&gt;&lt;/a&gt;)&lt;/li&gt; &lt;li&gt;Timestamps by &lt;a href= "https://ramseylab.vercel.app/"&gt;&lt;strong&gt;Jolene&lt;/strong&gt;&lt;/a&gt;. Thanks!&lt;/li&gt; &lt;/ul&gt; &lt;p&gt;Intro music is by &lt;a href= "http://www.ronaldjenkees.com/"&gt;&lt;strong&gt;Ronald Jenkees&lt;/strong&gt;&lt;/a&gt;&lt;/p&gt; &lt;p&gt;Send your questions for Dr. Griffin to daniel@microbe.tv&lt;/p&gt;</description>

This Week in Virology

Vincent Racaniello

TWiV 1174: Clinical update with Dr. Daniel Griffin

DEC 14, 202449 MIN
This Week in Virology

TWiV 1174: Clinical update with Dr. Daniel Griffin

DEC 14, 202449 MIN

Description

In his weekly clinical update, Dr. Griffin deep dives into whether the mysterious respiratory illness in the Congo is malaria, and in conjunction with your host Vincent Racaniello discusses the failure of the poliovirus eradication campaign with virus circulation detected throughout Europe and how we should focus on disease control not virus circulation, then returns to discussing avian influenza in raw milk and the early stoppage of the mpox antiviral Tecovirimat  before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, if there is a difference in protection against the development of severe disease between an mRNA or a protein based vaccine, where to find PEMGARDA, and information for Columbia Unversity Irving Medical Center’s long COVID treatment center.

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Links for this episode
  • IIs the mysterious disease in the Congo, malaria? (AP News)
  • State of global health, year-end remarks by WHO director-general (WHO)
  • Really, progress towards poliomyelitis eradication? (CDC MMWR)
  • Increases in confirm cases ¹ control of poliomyelitis (WHO)
  • Polio European Union and United Kingdom, is that 1 global entry? (Science)
  • Is the WHO the global CDC?  polio vaccination guidelines (WHO)
  • Do you feed your cats raw milk? (Public Health LA county)
  • Is there avian influenza in the zoo near you? (Maricopa)
  • Don’t feed your cat raw milk (CIDRAP)
  • Holy Cow! H5N1 in cows! (microbeTV)
  • Tecovirimat no improvement in Mpox resolution or pain(NIAID NIH)
  • Interim results from STOMP study of  Tecovirimat (SIGA)
  • Trial stops enrollment after Tpoxx fails (CIDRAP)
  • Is Tecovirimat really first-in-class mpox therapy? (Viruses)
  • Influenza weekly surveillance report: clift notes (CDC FluView)
  • US respiratory virus activity (CDC Respiratory Illnesses)
  • Waste water scan for 11 pathogens (WastewaterSCan)
  • RSV-Network (CDC Respiratory Syncytial virus Infection)
  • COVID-19 deaths (CDC)
  • COVID-19 national and regional trends (CDC)
  • Waste water scan for 11 pathogens (WastewaterSCan)
  • COVID-19 variant tracker (CDC)
  • SARS-CoV-2 genomes galore (Nextstrain)
  • Relative effectiveness of homologous NVX-CoV2373 and BNT162b2 COVID-19 vaccinations in South Korea (Vaccine)
  • Phase III trial results! Comparative efficacy and safety of COVID-19 (BMC Infectious Diseases)
  • Where to get pemgarda (Pemgarda)
  • EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
  • Fusion center near you….if in NY (Prime Fusions)
  • CDC Quarantine guidelines (CDC)
  • NIH COVID-19 treatment guidelines (NIH)
  • Infectious Disease Society guidelines for treatment and management (ID Society)
  • Drug interaction checker (University of Liverpool)
  • Molnupiravir safety and efficacy (JMV)
  • Convalescent plasma recommendation for immunocompromised (ID Society)
  • What to do when sick with a respiratory virus (CDC)
  • When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
  • Managing healthcare staffing shortages (CDC)
  • Stop playing favorites with COVID-19 in healthcare settings (Infection Control & Hospital Epidemiology)
  • Steroids, dexamethasone at the right time (OFID)
  • Anticoagulation guidelines (hematology.org)
  • Remdesivir Effectiveness in Reducing the Risk of 30-day Readmission in Vulnerable Patients Hospitalized for COVID-19 (CID)
  • Daniel Griffin’s evidence based medical practices for long COVID (OFID)
  • Long COVID hotline (Columbia : Columbia University Irving Medical Center)
  • Letters read on TWiV 1174
  • Dr. Griffin’s COVID treatment summary (pdf)
  • Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]