<description>&lt;p&gt;In his weekly clinical update, Dr. Griffin with Vincent Racaniello mourn the demise of vaccination against childhood diseases when discussing the continuing measles outbreak and the rise of pertussis, the first human case of H5N1 in Mexico, and human metapneumovirus before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections and vaccination schedules, the WasterwaterScan dashboard, where to find PEMGARDA, provides information for Columbia University Irving Medical Center's long COVID treatment center, where to go for answers to your long COVID questions, long COVID interventions, if antiviral therapy prevents long COVID and how long COVID may affect brain volume.&lt;/p&gt; &lt;div class="fluid-width-video-wrapper"&gt;Subscribe (free): &lt;a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"&gt;&lt;strong&gt;Apple Podcasts&lt;/strong&gt;&lt;/a&gt;, &lt;a href= "http://twiv.microbeworld.libsynpro.com/twiv"&gt;&lt;strong&gt;RSS&lt;/strong&gt;&lt;/a&gt;, &lt;a href="http://eepurl.com/Gcw59"&gt;&lt;strong&gt;email&lt;/strong&gt;&lt;/a&gt;&lt;/div&gt; &lt;p&gt;Become a &lt;a href= "https://www.microbe.tv/contribute"&gt;&lt;strong&gt;patron&lt;/strong&gt;&lt;/a&gt; of TWiV!&lt;/p&gt; &lt;h3 id="links-for-this-episode" class="wp-block-heading"&gt; &lt;strong&gt;Links for this episode&lt;/strong&gt;&lt;/h3&gt; &lt;ul class="wp-block-list"&gt; &lt;li&gt;A natural experiment on the effect of &lt;a href= "https://www.nature.com/articles/s41586-025-08800-x"&gt;&lt;strong&gt;herpes zoster vaccination&lt;/strong&gt;&lt;/a&gt; on dementia (Nature)&lt;/li&gt; &lt;li&gt;Taking a &lt;a href= "https://www.microbe.tv/twiv/twiv-1207/"&gt;&lt;strong&gt;shot at dementia&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt; &lt;/strong&gt;(microbeTV: TWiV)&lt;/li&gt; &lt;li&gt;RFK Jr. visits Texas after &lt;a href= "https://docs.google.com/document/d/1UEfBYt2bH3DsGA16NEDFtlJlNP7V8cU-YgwaT2GBQWE/edit?tab=t.0#heading=h.bbdcdnfh27a"&gt;&lt;strong&gt;second child dies&lt;/strong&gt;&lt;/a&gt; of measles amid outbreak (Washington Post)&lt;/li&gt; &lt;li&gt;Kennedy Attends &lt;a href= "https://www.nytimes.com/2025/04/06/health/measles-death-texas.html"&gt;&lt;strong&gt;Funeral&lt;/strong&gt;&lt;/a&gt; of Texas Girl Who Died of Measles(NY Times)&lt;/li&gt; &lt;li&gt;'&lt;a href= "https://www.statnews.com/2025/04/06/rfk-jr-measles-statement-west-texas-outbreak/#:~:text=WASHINGTON%20%E2%80%94%20Health%20secretary%20Robert%20F,the%20outbreak%20in%20West%20Texas"&gt;&lt;strong&gt;Most effective way'&lt;/strong&gt;&lt;/a&gt; to prevent measles is vaccination, RFK Jr. says, in most direct remarks yet (STAT News)&lt;/li&gt; &lt;li&gt;Fort Bliss…..&lt;a href= "https://www.ktsm.com/news/beaumont-army-hospital-confirms-measles-case-at-fort-bliss/"&gt;&lt;strong&gt;Fort measles&lt;/strong&gt;&lt;/a&gt;: Beaumont Army hospital confirms measles case at Fort Bliss(KTSM News)&lt;/li&gt; &lt;li&gt;Measles &lt;a href= "https://www.cdc.gov/measles/data-research/index.html"&gt;&lt;strong&gt;cases and outbreaks&lt;/strong&gt;&lt;/a&gt; (CDC Rubeola)&lt;/li&gt; &lt;li&gt;Measles 159 in &lt;a href= "https://www.dshs.texas.gov/news-alerts/measles-outbreak-2025"&gt;&lt;strong&gt;Texas&lt;/strong&gt;&lt;/a&gt;…. (Texas Health and Human Services)&lt;/li&gt; &lt;li&gt;Measles vaccine recommendations from NYP (&lt;a href= "https://www.microbe.tv/twiv/wp-content/uploads/sites/2/Measles_vax_rec.jpg"&gt;jpg&lt;/a&gt;)&lt;/li&gt; &lt;li&gt;2025 &lt;a href= "https://www.nmhealth.org/about/erd/ideb/mog/"&gt;&lt;strong&gt;Measles outbreak guidance&lt;/strong&gt;&lt;/a&gt; (New Mexico Health)&lt;/li&gt; &lt;li&gt;Get the &lt;a href= "https://www.health.ny.gov/diseases/communicable/measles/"&gt;&lt;strong&gt;FACTS&lt;/strong&gt;&lt;/a&gt; about measles (NY State Department of Health)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://www.cdc.gov/measles/hcp/vaccine-considerations/index.html"&gt; &lt;strong&gt;Measles&lt;/strong&gt;&lt;/a&gt; (CDC Measles (Rubeola))&lt;/li&gt; &lt;li&gt;&lt;a href= "https://www.cdc.gov/measles/index.html"&gt;&lt;strong&gt;Measles&lt;/strong&gt;&lt;/a&gt; vaccine (CDC Measles (Rubeola)&lt;/li&gt; &lt;li&gt;&lt;a href= "file:///Users/Amy/Desktop/Measles%20(CDC%20Measles%20(Rubeola))"&gt;&lt;strong&gt; Presumptive evidence&lt;/strong&gt;&lt;/a&gt; of measles immunity (CDC)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://www.cdc.gov/pinkbook/hcp/table-of-contents/chapter-13-measles.html#cdc_report_pub_study_section_9-contraindications-and-precautions-to-vaccination"&gt; &lt;strong&gt;Contraindications and precautions&lt;/strong&gt;&lt;/a&gt; to measles vaccination (CDC)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://www.cdc.gov/measles/hcp/vaccine-considerations/index.html"&gt; &lt;strong&gt;Measles&lt;/strong&gt;&lt;/a&gt; (CDC Measles (Rubeola))&lt;/li&gt; &lt;li&gt;&lt;a href= "https://www.youtube.com/watch?v=-16RnFwe0jc"&gt;&lt;strong&gt;Doctors' talk measles&lt;/strong&gt;&lt;/a&gt; (YouTube)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://www.cdc.gov/measles/index.html"&gt;&lt;strong&gt;Measles&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt; &lt;/strong&gt;(CDC: Measles Rubeola)&lt;/li&gt; &lt;li&gt;Adverse events associated with &lt;a href= "https://www.ncbi.nlm.nih.gov/books/NBK236284/#:~:text=The%20evidence%20favors%20acceptance%20of,in%20temporal%20relation%20to%20vaccination"&gt;&lt;strong&gt;childhood vaccines&lt;/strong&gt;&lt;/a&gt;: evidence bearing on causality (NLM)&lt;/li&gt; &lt;li&gt;Measles &lt;a href= "https://www.idsociety.org/public-health/measles/know-the-facts/"&gt;&lt;strong&gt;Vaccination:&lt;/strong&gt;&lt;/a&gt; Know the Facts(ISDA: Infectious Diseases Society of America)&lt;/li&gt; &lt;li&gt;Deaths following vaccination: what does the &lt;a href= "https://www.sciencedirect.com/science/article/abs/pii/S0264410X15006556?via%3Dihub"&gt;&lt;strong&gt;evidence show&lt;/strong&gt;&lt;/a&gt; (Vaccine)&lt;/li&gt; &lt;li&gt;Two infants die of &lt;a href= "https://www.cnn.com/2025/04/02/health/whooping-cough-pertussis-louisiana/index.html"&gt;&lt;strong&gt;whooping cough&lt;/strong&gt;&lt;/a&gt; in Louisiana (CNN)&lt;/li&gt; &lt;li&gt;Clinical features of &lt;a href= "https://www.cdc.gov/pertussis/hcp/clinical-signs/index.html"&gt;&lt;strong&gt;pertussis&lt;/strong&gt;&lt;/a&gt; (CDC: Whooping cough Pertussis)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://www.cdc.gov/pertussis/hcp/vaccine-recommendations/index.html"&gt; &lt;strong&gt;Pertussis vaccination&lt;/strong&gt;&lt;/a&gt; recommendations (CDC: Whooping cough Pertussis)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://www.cdc.gov/diphtheria/vaccines/index.html"&gt;&lt;strong&gt;Diphtheria vaccination&lt;/strong&gt;&lt;/a&gt; (CDC: Diphtheria)&lt;/li&gt; &lt;li&gt;Mexico's &lt;a href= "https://www.reuters.com/business/healthcare-pharmaceuticals/mexico-reports-first-human-case-h5n1-bird-flu-2025-04-04/"&gt;&lt;strong&gt;first human case&lt;/strong&gt;&lt;/a&gt; of H5N1 (Reuters)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://www.cdc.gov/mmwr/volumes/74/wr/mm7411a1.htm?s_cid=mm7411a1_e&amp;ACSTrackingID=USCDC_921-DM146188&amp;ACSTrackingLabel=This%20Week%20in%20MMWR%3A%20Vol.%2074%2C%20April%203%2C%202025&amp;deliveryName=USCDC_921-DM146188"&gt; &lt;strong&gt;Human metapneumovirus&lt;/strong&gt;&lt;/a&gt; seasonality and co-circulation with respiratory syncytial virus — United States, 2014–2024 (CDC: MMWR)&lt;/li&gt; &lt;li&gt;Influenza: Wastewater scan for &lt;a href= "https://data.wastewaterscan.org/?charts=CjIQACABSABaBk4gR2VuZXIKMjAyNC0wOC0wN3IKMjAyNC0wOS0xOIoBBmQ0MzllMsABAQ%3D%3D&amp;selectedChartId=d439e2"&gt;&lt;strong&gt;11 pathogens&lt;/strong&gt;&lt;/a&gt; (WastewaterSCan)&lt;/li&gt; &lt;li&gt;US&lt;a href= "https://www.cdc.gov/respiratory-viruses/data/activity-levels.html"&gt; &lt;strong&gt;respiratory&lt;/strong&gt;&lt;/a&gt; virus activity (CDC Respiratory Illnesses)&lt;/li&gt; &lt;li&gt;Weekly surveillance report: &lt;a href= "https://www.cdc.gov/fluview/surveillance/2024-week-37.html"&gt;&lt;strong&gt;clift notes&lt;/strong&gt;&lt;/a&gt; (CDC FluView)&lt;/li&gt; &lt;li&gt;Respiratory virus &lt;a href= "https://www.cdc.gov/respiratory-viruses/data/activity-levels.html"&gt;&lt;strong&gt;activity&lt;/strong&gt;&lt;/a&gt; levels (CDC Respiratory Illnesses)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://www.fda.gov/vaccines-blood-biologics/influenza-vaccine-composition-2025-2026-us-influenza-season?mtm_source=25"&gt; &lt;strong&gt;FDA-CDC-DOD:&lt;/strong&gt;&lt;/a&gt; 2025-2046 influenza vaccine composition (FDA)&lt;/li&gt; &lt;li&gt;RSV: Waste water scan for &lt;a href= "https://data.wastewaterscan.org/?charts=CjIQACABSABaBk4gR2VuZXIKMjAyNC0wOC0wN3IKMjAyNC0wOS0xOIoBBmQ0MzllMsABAQ%3D%3D&amp;selectedChartId=d439e2"&gt;&lt;strong&gt;11 pathogens&lt;/strong&gt;&lt;/a&gt; (WastewaterSCan)&lt;/li&gt; &lt;li&gt;US&lt;a href= "https://www.cdc.gov/respiratory-viruses/data/activity-levels.html"&gt; &lt;strong&gt;respiratory&lt;/strong&gt;&lt;/a&gt; virus activity (CDC Respiratory Illnesses)&lt;/li&gt; &lt;li&gt;RSV-&lt;a href= "https://www.cdc.gov/rsv/php/surveillance/rsv-net.html"&gt;&lt;strong&gt;Net&lt;/strong&gt;&lt;/a&gt;work (CDC Respiratory Syncytial virus Infection)&lt;/li&gt; &lt;li&gt;Waste water scan for &lt;a href= "https://data.wastewaterscan.org/?charts=CjIQACABSABaBk4gR2VuZXIKMjAyNC0wOC0wN3IKMjAyNC0wOS0xOIoBBmQ0MzllMsABAQ%3D%3D&amp;selectedChartId=d439e2"&gt;&lt;strong&gt;11 pathogens&lt;/strong&gt;&lt;/a&gt; (WastewaterSCan)&lt;/li&gt; &lt;li&gt;COVID-19 &lt;a href= "https://covid.cdc.gov/covid-data-tracker/#maps_percent-covid-deaths"&gt;&lt;strong&gt;deaths&lt;/strong&gt;&lt;/a&gt; (CDC)&lt;/li&gt; &lt;li&gt;COVID-19 &lt;a href= "https://www.cdc.gov/nwss/rv/COVID19-nationaltrend.html"&gt;&lt;strong&gt;national and regional&lt;/strong&gt;&lt;/a&gt; trends (CDC)&lt;/li&gt; &lt;li&gt;COVID-19 &lt;a href= "https://covid.cdc.gov/covid-data-tracker/index.html#variant-proportions"&gt;&lt;strong&gt;variant tracker&lt;/strong&gt;&lt;/a&gt; (CDC)&lt;/li&gt; &lt;li&gt;SARS-CoV-2 &lt;a href= "https://nextstrain.org/ncov/gisaid/global/all-time?d=tree,frequencies&amp;p=full&amp;r=division&amp;showBranchLabels=all&amp;tl=none"&gt;&lt;strong&gt;genomes&lt;/strong&gt;&lt;/a&gt; galore (Nextstrain)&lt;/li&gt; &lt;li&gt;Human source SARS-CoV-2 &lt;a href= "https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofaf196/8102227?utm_source=advanceaccess&amp;utm_campaign=ofid&amp;utm_medium=email"&gt;&lt;strong&gt;aerosol transmission&lt;/strong&gt;&lt;/a&gt; to remote sentinel hamsters (OFID)&lt;/li&gt; &lt;li&gt;Interim clinical considerations for &lt;a href= "https://www.cdc.gov/vaccines/covid-19/clinical-considerations/interim-considerations-us.html"&gt;&lt;strong&gt;use of COVID-19 vaccines&lt;/strong&gt;&lt;/a&gt; in the United States (CDC Vaccines &amp; Immunizations)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://www.pemgarda.com/hcp/infusion-center-locator/"&gt;&lt;strong&gt;Where&lt;/strong&gt;&lt;/a&gt; to get pemgarda (Pemgarda)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://investors.adagiotx.com/news-releases/news-release-details/invivyd-announces-fda-authorization-emergency-use-pemgardatm"&gt; &lt;strong&gt;EUA&lt;/strong&gt;&lt;/a&gt;&lt;strong&gt; &lt;/strong&gt;for the pre-exposure prophylaxis of COVID-19 (INVIYD)&lt;/li&gt; &lt;li&gt;Fusion &lt;a href= "https://primeinfusions.com/locations/"&gt;&lt;strong&gt;center&lt;/strong&gt;&lt;/a&gt; (Prime Fusions)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://www.cdc.gov/respiratory-viruses/guidance/faqs.html?CDC_AAref_Val=https://www.cdc.gov/respiratory-viruses/guidance/faq.html"&gt; &lt;strong&gt;CDC Quarantine&lt;/strong&gt;&lt;/a&gt; guidelines (CDC)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://www.ncbi.nlm.nih.gov/books/NBK570371/"&gt;&lt;strong&gt;NIH&lt;/strong&gt;&lt;/a&gt; COVID-19 treatment guidelines (NIH)&lt;/li&gt; &lt;li&gt;Drug interaction &lt;a href= "https://covid19-druginteractions.org/checker"&gt;&lt;strong&gt;checker&lt;/strong&gt;&lt;/a&gt; (University of Liverpool)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://www.idsociety.org/practice-guideline/covid-19-guideline-treatment-and-management/#ExecutiveSummaryandBackground"&gt; &lt;strong&gt;Infectious Disease Society guidelines&lt;/strong&gt;&lt;/a&gt; for treatment and management (ID Society)&lt;/li&gt; &lt;li&gt;&lt;strong&gt;&lt;a href= "https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofaf187/8096248?utm_source=advanceaccess&amp;utm_campaign=ofid&amp;utm_medium=email"&gt; Cost-effectiveness&lt;/a&gt;&lt;/strong&gt; analysis of nirmatrelvir/ritonavir for high-risk individuals with COVID-19….does this mean use the big button calculator? (OFID)&lt;/li&gt; &lt;li&gt;Molnupiravir &lt;a href= "https://onlinelibrary.wiley.com/doi/10.1002/jmv.28011"&gt;&lt;strong&gt;safety&lt;/strong&gt;&lt;/a&gt; and efficacy (JMV)&lt;/li&gt; &lt;li&gt;Convalescent plasma recommendation for &lt;a href= "https://www.idsociety.org/practice-guideline/covid-19-guideline-treatment-and-management/"&gt;&lt;strong&gt;immunocompromised&lt;/strong&gt;&lt;/a&gt; (ID Society)&lt;/li&gt; &lt;li&gt;What to do when sick with a &lt;a href= "https://www.cdc.gov/ncird/whats-new/updated-respiratory-virus-guidance.html"&gt;&lt;strong&gt;respiratory virus&lt;/strong&gt;&lt;/a&gt; (CDC)&lt;/li&gt; &lt;li&gt;When your healthcare provider is &lt;a href= "https://www.cdc.gov/covid/hcp/infection-control/guidance-risk-assesment-hcp.html?CDC_AAref_Val=https://www.cdc.gov/coronavirus/2019-ncov/hcp/guidance-risk-assesment-hcp.html"&gt;&lt;strong&gt;infected/exposed&lt;/strong&gt;&lt;/a&gt; with SARS-CoV-2 (CDC)&lt;/li&gt; &lt;li&gt;Managing healthcare staffing &lt;a href= "https://www.cdc.gov/covid/hcp/infection-control/mitigating-staff-shortages.html?CDC_AAref_Val=https://www.cdc.gov/coronavirus/2019-ncov/hcp/mitigating-staff-shortages.html"&gt;&lt;strong&gt;shortages&lt;/strong&gt;&lt;/a&gt; (CDC)&lt;/li&gt; &lt;li&gt;Steroids, &lt;a href= "https://academic.oup.com/ofid/article/10/3/ofad105/7055978"&gt;&lt;strong&gt;dexamethasone&lt;/strong&gt;&lt;/a&gt; at the right time (OFID)&lt;/li&gt; &lt;li&gt;&lt;a href= "https://www.hematology.org/education/clinicians/guidelines-and-quality-care/clinical-practice-guidelines/venous-thromboembolism-guidelines/ash-guidelines-on-use-of-anticoagulation-in-patients-with-covid-19"&gt; &lt;strong&gt;Anticoagulation&lt;/strong&gt;&lt;/a&gt; guidelines (hematology.org)&lt;/li&gt; &lt;li&gt;Daniel Griffin's &lt;a href= "https://academic.oup.com/ofid/article/11/9/ofae462/7733485"&gt;&lt;strong&gt;evidence based&lt;/strong&gt;&lt;/a&gt; medical practices for long COVID (OFID)&lt;/li&gt; &lt;li&gt;Long COVID &lt;a href= "https://www.columbiadoctors.org/health-library/article/long-covid/"&gt;&lt;strong&gt;hotline&lt;/strong&gt;&lt;/a&gt; (Columbia : Columbia University Irving Medical Center)&lt;/li&gt; &lt;li&gt;&lt;a href="https://longcovidtheanswers.com/"&gt;&lt;strong&gt;The answers:&lt;/strong&gt;&lt;/a&gt; Long COVID&lt;/li&gt; &lt;li&gt;Nirmatrelvir–ritonavir versus placebo–ritonavir in individuals with &lt;a href= "https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00073-8/fulltext"&gt;&lt;strong&gt;long COVID&lt;/strong&gt;&lt;/a&gt; in the USA (PAX LC): (LANCET: Infectious Diseases)&lt;/li&gt; &lt;li&gt;Quantitative &lt;a href= "https://www.sciencedirect.com/science/article/pii/S105381192500148X"&gt;&lt;strong&gt;brain volume differences&lt;/strong&gt;&lt;/a&gt; between COVID-19 patients and non-COVID-19 volunteers (NeuroImage&lt;strong&gt;)&lt;/strong&gt;&lt;/li&gt; &lt;li&gt;&lt;a href= "https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2831649"&gt; &lt;strong&gt;Donepezil&lt;/strong&gt;&lt;/a&gt; for fatigue and psychological symptoms in post–covid-19 condition (JAMA Network Open&lt;strong&gt;)&lt;/strong&gt;&lt;/li&gt; &lt;li&gt;&lt;strong&gt;&lt;a title="" href= "https://www.microbe.tv/twiv/twiv-1208-letters/"&gt;Letters read&lt;/a&gt; &lt;/strong&gt;on TWiV 1208&lt;/li&gt; &lt;li&gt;Dr. Griffin's COVID treatment summary (&lt;a title="" href= "https://twiv.s3.amazonaws.com/COVID+treatment+summary+032224.pdf"&gt;&lt;strong&gt;pdf&lt;/strong&gt;&lt;/a&gt;)&lt;/li&gt; &lt;li&gt;Timestamps by &lt;a href= "https://ramseylab.vercel.app/"&gt;&lt;strong&gt;Jolene Ramsey&lt;/strong&gt;&lt;/a&gt;. Thanks!&lt;/li&gt; &lt;/ul&gt; &lt;p&gt;Intro music is by &lt;a href= "http://www.ronaldjenkees.com/"&gt;&lt;strong&gt;Ronald Jenkees&lt;/strong&gt;&lt;/a&gt;&lt;/p&gt; &lt;p&gt;Send your questions for Dr. Griffin to daniel@microbe.tv&lt;/p&gt; &lt;p&gt;Content in this podcast should not be construed as medical advice.&lt;/p&gt;</description>

This Week in Virology

Vincent Racaniello

TWiV 1208: Clinical update with Dr. Daniel Griffin

APR 12, 202549 MIN
This Week in Virology

TWiV 1208: Clinical update with Dr. Daniel Griffin

APR 12, 202549 MIN

Description

In his weekly clinical update, Dr. Griffin with Vincent Racaniello mourn the demise of vaccination against childhood diseases when discussing the continuing measles outbreak and the rise of pertussis, the first human case of H5N1 in Mexico, and human metapneumovirus before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections and vaccination schedules, the WasterwaterScan dashboard, where to find PEMGARDA, provides information for Columbia University Irving Medical Center's long COVID treatment center, where to go for answers to your long COVID questions, long COVID interventions, if antiviral therapy prevents long COVID and how long COVID may affect brain volume.

Subscribe (free): Apple Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

Content in this podcast should not be construed as medical advice.