<description>&lt;p&gt;TWiV explains the Nobel Prize-winning discovery of pre-mRNA splicing, and engineering bacteriophage to deliver proteins to the human intestine.&lt;/p&gt; &lt;div class="fluid-width-video-wrapper"&gt;Hosts: &lt;a title="" href="https://en.wikipedia.org/wiki/Vincent_Racaniello"&gt;Vincent Racaniello&lt;/a&gt;, &lt;a title="" href= "https://medschool.umich.edu/profile/879/katherine-spindler"&gt;Kathy Spindler&lt;/a&gt;, and &lt;a title="" href= "https://bbarkerdrew.com/"&gt;Brianne Barker&lt;/a&gt;&lt;/div&gt; &lt;p&gt;Subscribe (free): &lt;a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"&gt; Apple Podcasts&lt;/a&gt;, &lt;a href= "http://twiv.microbeworld.libsynpro.com/twiv"&gt;RSS&lt;/a&gt;, &lt;a href="http://eepurl.com/Gcw59"&gt;email&lt;/a&gt;&lt;/p&gt; &lt;p&gt;Become a &lt;a href= "https://www.microbe.tv/contribute"&gt;patron&lt;/a&gt; of TWiV!&lt;/p&gt; &lt;h3 id="links-for-this-episode" class="wp-block-heading"&gt;Links for this episode&lt;/h3&gt; &lt;ul class="wp-block-list"&gt; &lt;li&gt;&lt;a title="" href="https://www.microbe.tv/contribute"&gt;Support science education &lt;/a&gt;at MicrobeTV&lt;/li&gt; &lt;li&gt;Immune 100 &lt;a title="" href= "https://www.eventbrite.com/e/immune-100-live-in-nyc-tickets-1797664816859?aff=oddtdtcreator"&gt;live at the Incubator&lt;/a&gt;&lt;/li&gt; &lt;li&gt;&lt;a title="" href= "https://pmc.ncbi.nlm.nih.gov/articles/PMC431482/"&gt;Spliced segments&lt;/a&gt; of adenovirus mRNA (PNAS)&lt;/li&gt; &lt;li&gt;An &lt;a title="" href= "https://pubmed.ncbi.nlm.nih.gov/902310/"&gt;amazing sequence&lt;/a&gt; in adenovirus mRNA (Cell)&lt;/li&gt; &lt;li&gt;Nobel Prize for &lt;a title="" href= "https://www.nobelprize.org/prizes/medicine/1993/press-release/"&gt;mRNA splicing&lt;/a&gt; (Nobel)&lt;/li&gt; &lt;li&gt;A &lt;a title="" href= "https://pubmed.ncbi.nlm.nih.gov/884734/"&gt;predominant undecanucleotide&lt;/a&gt; in adenovirus late mRNAs (Cell)&lt;/li&gt; &lt;li&gt;&lt;a title="" href= "https://www.microbe.tv/twiv/twiv-462/"&gt;Splicing RNA &lt;/a&gt;with Phillip A. Sharp (ASM)&lt;/li&gt; &lt;li&gt;Protein production in the gut by &lt;a title="" href= "https://www.nature.com/articles/s41587-025-02570-7"&gt;engineered phage&lt;/a&gt; (Nat Biotech)&lt;/li&gt; &lt;li&gt;&lt;a title="" href= "https://doi.org/10.1016/j.coviro.2022.101255"&gt;Engineered&lt;/a&gt; phage T4 (Curr Op Virol)&lt;/li&gt; &lt;li&gt;Timestamps by &lt;a href= "https://ramseylab.vercel.app/"&gt;Jolene&lt;/a&gt; Ramsey. Thanks!&lt;/li&gt; &lt;/ul&gt; &lt;h3 class="wp-block-heading"&gt;Weekly Picks&lt;/h3&gt; &lt;p&gt;&lt;strong&gt;Brianne&lt;/strong&gt; – &lt;a href= "https://www.nytimes.com/interactive/2025/11/24/books/review/classic-sf-quotes.html"&gt;Can You Identify These Lines from Classic SciFi Novels?&lt;/a&gt;&lt;br /&gt; &lt;strong&gt;Kathy&lt;/strong&gt; –&lt;a href= "https://www.youtube.com/watch?v=yvY61ArnxPg&amp;list=PLkCzlk8e8aNfPZoSgvp6m-aRmY4lsUbD6&amp;index=3&amp;pp=iAQB"&gt; &lt;/a&gt;&lt;a href="https://www.youtube.com/watch?v=48A-tlOvml0&amp;t=2354s"&gt;Saturday Morning Physics, Photograph 51&lt;/a&gt; and &lt;a href= "https://pubs.acs.org/doi/10.1021/ed076p378"&gt;JCE article&lt;/a&gt;&lt;br /&gt; &lt;strong&gt;Rich&lt;/strong&gt; – &lt;a href= "https://en.wikipedia.org/wiki/Wikipedia:Wiki_Science_Competition_2025_in_the_United_States"&gt;Wikipedia:Wiki Science Competition 2025 in the United States&lt;/a&gt;&lt;br /&gt; &lt;strong&gt;Jolene&lt;/strong&gt; – &lt;a title="" href= "https://bookdown.org/taiawu/data_viz_course/"&gt;Data visualization workshop&lt;/a&gt;&lt;br /&gt; &lt;strong&gt;Vincent&lt;/strong&gt; – &lt;a href= "https://www.amazon.com/dp/B09KMPKGXK?ref=ppx_yo2ov_dt_b_fed_digi_asin_title_351"&gt;Transformer: The Deep Chemistry of Life and Death&lt;/a&gt; by Nick Lane&lt;/p&gt; &lt;p&gt;Intro music is by &lt;a href= "http://www.ronaldjenkees.com/"&gt;Ronald Jenkees&lt;/a&gt;&lt;/p&gt; &lt;p&gt;Send your virology questions and comments to twiv@microbe.tv&lt;/p&gt; &lt;p&gt;Content in this podcast should not be construed as medical advice.&lt;/p&gt;</description>

This Week in Virology

Vincent Racaniello

TWiV 1275: An amazing sequence and a gutsy therapy

NOV 30, 2025108 MIN
This Week in Virology

TWiV 1275: An amazing sequence and a gutsy therapy

NOV 30, 2025108 MIN

Description

TWiV explains the Nobel Prize-winning discovery of pre-mRNA splicing, and engineering bacteriophage to deliver proteins to the human intestine.

Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker

Subscribe (free): Apple Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode Weekly Picks

Brianne – Can You Identify These Lines from Classic SciFi Novels? Kathy – Saturday Morning Physics, Photograph 51 and JCE article Rich – Wikipedia:Wiki Science Competition 2025 in the United States Jolene – Data visualization workshop Vincent – Transformer: The Deep Chemistry of Life and Death by Nick Lane

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Content in this podcast should not be construed as medical advice.