<description>&lt;p&gt;TWiV explains how the dengue virus protein NS1 alters Aedes aegypti midgut permeability and favors virus dissemination, and achieving a complete hepatitis B virus cure in chronic hepatitis B virus-infected humanized mice by using a capsid assembly modulator.&lt;/p&gt; &lt;div class="fluid-width-video-wrapper"&gt;Hosts: &lt;a title="" href="https://en.wikipedia.org/wiki/Vincent_Racaniello"&gt;Vincent Racaniello&lt;/a&gt;, &lt;a title="" href= "http://www.alandove.com/"&gt;Alan Dove&lt;/a&gt;, and Angela Mingarelli&lt;/div&gt; &lt;p&gt;Subscribe (free): &lt;a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"&gt; Apple Podcasts&lt;/a&gt;, &lt;a href= "http://twiv.microbeworld.libsynpro.com/twiv"&gt;RSS&lt;/a&gt;, &lt;a href="http://eepurl.com/Gcw59"&gt;email&lt;/a&gt;&lt;/p&gt; &lt;p&gt;Become a &lt;a href= "https://www.microbe.tv/contribute"&gt;patron&lt;/a&gt; of TWiV!&lt;/p&gt; &lt;h3 id="links-for-this-episode" class="wp-block-heading"&gt;Links for this episode&lt;/h3&gt; &lt;ul class="wp-block-list"&gt; &lt;li&gt;&lt;a title="" href="https://www.microbe.tv/contribute"&gt;Support science education &lt;/a&gt;at MicrobeTV&lt;/li&gt; &lt;li&gt;&lt;a title="" href="https://asv.memberclicks.net/"&gt;ASV 2026&lt;/a&gt;&lt;/li&gt; &lt;li&gt;Positions in Rosenfeld Lab &lt;a title="" href= "https://www.microbe.tv/twiv/RosenfeldA@mlhs.org"&gt;(email)&lt;/a&gt;&lt;/li&gt; &lt;li&gt;Dengue virus NS1 &lt;a title="" href= "https://journals.asm.org/doi/10.1128/mbio.03173-25"&gt;alters mosquito midgut permeability&lt;/a&gt; (mBio)&lt;/li&gt; &lt;li&gt;HBV cure with a &lt;a title="" href= "https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(25)00497-4"&gt;capsid assembly modulator&lt;/a&gt; (Cell Host Microbe)&lt;/li&gt; &lt;li&gt;&lt;a title="" href= "https://www.microbe.tv/twiv/twiv-1289-letters/"&gt;Letters read&lt;/a&gt; on TWiV 1289&lt;/li&gt; &lt;li&gt;Timestamps by &lt;a href= "https://ramseylab.vercel.app/"&gt;Jolene&lt;/a&gt; Ramsey. Thanks!&lt;/li&gt; &lt;/ul&gt; &lt;h3 class="wp-block-heading"&gt;Weekly Picks&lt;/h3&gt; &lt;p&gt;&lt;strong&gt;Angela&lt;/strong&gt; – &lt;a title="" href= "https://www.nature.com/articles/s41598-019-56007-8#:~:text=Finally%2C%20periodic%20neural%20stimulation%20of%20muscles%20in,that%20intramuscular%20changes%20contribute%20to%20atrophy%20resistance"&gt;How hibernating bears maintain muscle mass&lt;/a&gt;&lt;br /&gt; &lt;strong&gt;Alan&lt;/strong&gt; – The flood of Chinese grad students in the 2000s &lt;a href= "https://www.science.org/content/article/flood-chinese-graduate-students-stem-was-boon-u-s-students"&gt;was a boon to US students&lt;/a&gt;.&lt;br /&gt; &lt;strong&gt;Vincent&lt;/strong&gt; – &lt;a href= "https://www.feynmanlectures.caltech.edu/index.html"&gt;Feynman Lectures on Physics&lt;/a&gt;&lt;/p&gt; &lt;h3 class="wp-block-heading"&gt;Listener Picks&lt;/h3&gt; &lt;p&gt;&lt;strong&gt;David&lt;/strong&gt; – &lt;a title="" href= "https://www.nytimes.com/2026/01/10/technology/stewart-cheifet-dead.html?unlocked_article_code=1.EFA.WRHK.J9Zy17FCeTr-&amp;smid=url-share"&gt;Stewart Cheifet, Host of TV's 'Computer Chronicles,' Dies at 87&lt;/a&gt;&lt;br /&gt; &lt;strong&gt;Charles&lt;/strong&gt; – &lt;a title="" href= "https://www.science.org/content/blog-post/last-year-and-year-come"&gt;Last Year, and the Year to Come&lt;/a&gt;&lt;/p&gt; &lt;p&gt;Intro music is by &lt;a href= "http://www.ronaldjenkees.com/"&gt;Ronald Jenkees&lt;/a&gt;&lt;/p&gt; &lt;p&gt;Send your virology questions and comments to twiv@microbe.tv&lt;/p&gt; &lt;p&gt;Content in this podcast should not be construed as medical advice.&lt;/p&gt;</description>

This Week in Virology

Vincent Racaniello

TWiV 1289: Building a better hepatitis B trap

JAN 18, 2026101 MIN
This Week in Virology

TWiV 1289: Building a better hepatitis B trap

JAN 18, 2026101 MIN

Description

TWiV explains how the dengue virus protein NS1 alters Aedes aegypti midgut permeability and favors virus dissemination, and achieving a complete hepatitis B virus cure in chronic hepatitis B virus-infected humanized mice by using a capsid assembly modulator. Hosts: Vincent Racaniello, Alan Dove, and Angela Mingarelli Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2026 Positions in Rosenfeld Lab (email) Dengue virus NS1 alters mosquito midgut permeability (mBio) HBV cure with a capsid assembly modulator (Cell Host Microbe) Letters read on TWiV 1289 Timestamps by Jolene Ramsey. Thanks! Weekly Picks Angela – How hibernating bears maintain muscle mass Alan – The flood of Chinese grad students in the 2000s was a boon to US students. Vincent – Feynman Lectures on Physics Listener Picks David – Stewart Cheifet, Host of TV's 'Computer Chronicles,' Dies at 87 Charles – Last Year, and the Year to Come Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.