<description>&lt;p&gt;TWiV explains emergence of a neurovirulent double recombinant from the 'improved' nOPV2 in Uganda, and efficiency of viral entry determined whether cells are latently or lytically infected with cytomegalovirus.&lt;/p&gt; &lt;div class="fluid-width-video-wrapper"&gt;Hosts: &lt;a title="" href="https://en.wikipedia.org/wiki/Vincent_Racaniello"&gt;Vincent Racaniello&lt;/a&gt;, &lt;a title="" href= "http://www.alandove.com/"&gt;Alan Dove&lt;/a&gt;, &lt;a title="" href= "https://mgm.ufl.edu/profile/condit-rich/"&gt;Rich Condit&lt;/a&gt;, and &lt;a title="" href="https://bbarkerdrew.com/"&gt;Brianne Barker&lt;/a&gt;&lt;/div&gt; &lt;p&gt;Subscribe (free): &lt;a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"&gt; Apple Podcasts&lt;/a&gt;, &lt;a href= "http://twiv.microbeworld.libsynpro.com/twiv"&gt;RSS&lt;/a&gt;, &lt;a href="http://eepurl.com/Gcw59"&gt;email&lt;/a&gt;&lt;/p&gt; &lt;p&gt;Become a &lt;a href= "https://www.microbe.tv/contribute"&gt;patron&lt;/a&gt; of TWiV!&lt;/p&gt; &lt;h3 id="links-for-this-episode" class="wp-block-heading"&gt;Links for this episode&lt;/h3&gt; &lt;ul class="wp-block-list"&gt; &lt;li&gt;&lt;a title="" href="https://www.microbe.tv/contribute"&gt;Support science education &lt;/a&gt;at MicrobeTV&lt;/li&gt; &lt;li&gt;&lt;a title="" href="https://asv.memberclicks.net/"&gt;ASV 2026&lt;/a&gt;&lt;/li&gt; &lt;li&gt;Positions in Rosenfeld Lab &lt;a title="" href= "https://www.microbe.tv/twiv/RosenfeldA@mlhs.org"&gt;(email)&lt;/a&gt;&lt;/li&gt; &lt;li&gt;nOPV2 neurovirulent recombinant in Uganda (Nat Micro)&lt;/li&gt; &lt;li&gt;&lt;a title="" href= "https://polioeradication.org/wp-content/uploads/2023/09/22nd-Report-of-The-Independent-Monitoring-Board-IMB.pdf"&gt; 2023 IMB report&lt;/a&gt; on polio eradication&lt;/li&gt; &lt;li&gt;Viral entry shapes &lt;a title="" href= "https://www.nature.com/articles/s41467-025-68063-y"&gt;HCMV latency establishment&lt;/a&gt; (Nat Comm)&lt;/li&gt; &lt;li&gt;&lt;a title="" href= "https://www.microbe.tv/twiv/twiv-1291-letters/"&gt;Letters read&lt;/a&gt; on TWiV 1291&lt;/li&gt; &lt;li&gt;Timestamps by &lt;a href= "https://ramseylab.vercel.app/"&gt;Jolene&lt;/a&gt; Ramsey. Thanks!&lt;/li&gt; &lt;/ul&gt; &lt;h3 class="wp-block-heading"&gt;Weekly Picks&lt;/h3&gt; &lt;p&gt;&lt;strong&gt;Brianne&lt;/strong&gt; – &lt;a href= "https://www.amazon.com/Dark-Matter-Novel-Blake-Crouch/dp/1101904240/ref=sr_1_3?crid=3OQOGY5A7DYW7&amp;dib=eyJ2IjoiMSJ9.xA11_B1ctj5S_8FGHdXd9Ha4rG40sSKmiYJu8c8ysSRZyQSBqH6sIxQ1KKVMCoDjaYjOSMBCQXG1lzJbuEuatDEyCy8-957kr-BNwJkakcFk4l-lEQJ2xcdz_oK91nWsGS1EwO4K1NFtPY9kjesTuRjshkNXhp0XfyrPHymf_ACA-DZ5RsrCmsyzpiSa32PJ4V93q_aHCR77vUkQxiWoL6AC3SXgx0WmIK5h98Qw-m0lG2G8bGtoW-A3UW8EzJbaZdrPX-kUPQn9EZ49GQ0BgJmqeDzb5oRhgRvfACDl74A.moY4dBCjG3EbPJKgpO3oJhfrGAlj0ahStqufItghPuk&amp;dib_tag=se&amp;keywords=blake+crouch&amp;qid=1769188223&amp;sprefix=blake+crouch%2Caps%2C158&amp;sr=8-3"&gt;Dark Matter&lt;/a&gt; by Blake Crouch&lt;br /&gt; &lt;strong&gt;Rich&lt;/strong&gt; – &lt;a href= "https://en.wikipedia.org/wiki/Sequoiadendron_giganteum"&gt;Sequoiadendron giganteum&lt;/a&gt;; &lt;a href= "https://www.nps.gov/seki/index.htm"&gt;Sequoia &amp; Kings Canyon National Park&lt;/a&gt;&lt;br /&gt; &lt;strong&gt;Alan&lt;/strong&gt; – &lt;a href= "https://www.amazon.com/Murderbot-Diaries-Vol-1/dp/1250389828"&gt;The Murderbot Diaries&lt;/a&gt; book series, by Martha Wells&lt;br /&gt; &lt;strong&gt;Vincent&lt;/strong&gt; – &lt;a href= "https://en.wikipedia.org/wiki/Surely_You%27re_Joking,_Mr._Feynman!"&gt;&lt;em&gt;Surely You're Joking, Mr. Feynman!&lt;/em&gt;&lt;/a&gt;&lt;/p&gt; &lt;h3 class="wp-block-heading"&gt;Listener Picks&lt;/h3&gt; &lt;p&gt;&lt;strong&gt;Rocky&lt;/strong&gt; – Cheetah mummies found in cave (&lt;a title="" href= "https://www.nature.com/articles/s43247-025-03021-6"&gt;Nature&lt;/a&gt;, &lt;a title="" href= "https://www.nationalgeographic.com/science/article/cheetah-mummies-genome-cave-saudi-arabia#:~:text=SCIENCE-,Cheetah%20mummies%20found%20in%20Arabian%20caves%20provide%20rare%20genome%20from,ideas%20for%20bringing%20it%20back"&gt;National Geographic&lt;/a&gt;)&lt;/p&gt; &lt;p&gt;Intro music is by &lt;a href= "http://www.ronaldjenkees.com/"&gt;Ronald Jenkees&lt;/a&gt;&lt;/p&gt; &lt;p&gt;Send your virology questions and comments to twiv@microbe.tv&lt;/p&gt; &lt;p&gt;Content in this podcast should not be construed as medical advice.&lt;/p&gt;</description>

This Week in Virology

Vincent Racaniello

TWiV 1291: A foot in the door for cytomegalovirus

JAN 25, 2026118 MIN
This Week in Virology

TWiV 1291: A foot in the door for cytomegalovirus

JAN 25, 2026118 MIN

Description

TWiV explains emergence of a neurovirulent double recombinant from the 'improved' nOPV2 in Uganda, and efficiency of viral entry determined whether cells are latently or lytically infected with cytomegalovirus. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2026 Positions in Rosenfeld Lab (email) nOPV2 neurovirulent recombinant in Uganda (Nat Micro) 2023 IMB report on polio eradication Viral entry shapes HCMV latency establishment (Nat Comm) Letters read on TWiV 1291 Timestamps by Jolene Ramsey. Thanks! Weekly Picks Brianne – Dark Matter by Blake Crouch Rich – Sequoiadendron giganteum; Sequoia & Kings Canyon National Park Alan – The Murderbot Diaries book series, by Martha Wells Vincent – Surely You're Joking, Mr. Feynman! Listener Picks Rocky – Cheetah mummies found in cave (Nature, National Geographic) Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.