<description>&lt;p&gt;TWiV explains research showing how HIV-1 signalling remodels nuclear pores to licence infection, and development of STING agonist nanoparticles to enable coordinated mucosal-systemic immunity for durable pan-β-coronavirus protection.&lt;/p&gt; &lt;div class="fluid-width-video-wrapper"&gt;Hosts: &lt;a title="" href="https://en.wikipedia.org/wiki/Vincent_Racaniello"&gt;V&lt;/a&gt;&lt;a title="" href="https://en.wikipedia.org/wiki/Vincent_Racaniello"&gt;Vincent Racaniello&lt;/a&gt;&lt;a title="" href= "https://en.wikipedia.org/wiki/Vincent_Racaniello"&gt;,&lt;/a&gt; &lt;a title= "" href="http://www.turbidplaque.com"&gt;Alan Dove&lt;/a&gt;&lt;a title="" href="https://en.wikipedia.org/wiki/Vincent_Racaniello"&gt;,&lt;/a&gt; &lt;a title="" href= "https://ufrfprofessors.research.ufl.edu/condit-richard/"&gt;Rich Condit&lt;/a&gt;&lt;a title="" href= "https://en.wikipedia.org/wiki/Vincent_Racaniello"&gt;, and&lt;/a&gt; &lt;a title="" href="https://bbarkerdrew.com/"&gt;Brianne Barker&lt;/a&gt;&lt;/div&gt; &lt;p&gt;Subscribe (free): &lt;a title= "http://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=300973784" href= "https://podcasts.apple.com/us/podcast/this-week-in-virology/id1176779065"&gt; Apple Podcasts&lt;/a&gt;, &lt;a href= "http://twiv.microbeworld.libsynpro.com/twiv"&gt;RSS&lt;/a&gt;, &lt;a href="http://eepurl.com/Gcw59"&gt;email&lt;/a&gt;&lt;/p&gt; &lt;p&gt;Become a &lt;a href= "https://www.microbe.tv/contribute"&gt;patron&lt;/a&gt; of TWiV!&lt;/p&gt; &lt;h3 id="links-for-this-episode" class="wp-block-heading"&gt;Links for this episode&lt;/h3&gt; &lt;ul class="wp-block-list"&gt; &lt;li&gt;&lt;a title="" href="https://www.microbe.tv/contribute"&gt;Support science education &lt;/a&gt;at MicrobeTV&lt;/li&gt; &lt;li&gt;Positions in Rosenfeld Lab &lt;a title="" href= "https://www.microbe.tv/twiv/RosenfeldA@mlhs.org"&gt;(email)&lt;/a&gt;&lt;/li&gt; &lt;li&gt;&lt;a title="" href= "https://www.who.int/emergencies/disease-outbreak-news/item/2026-DON607"&gt; Bundibugyo ebolavirus&lt;/a&gt; sitrep (WHO)&lt;/li&gt; &lt;li&gt;Ebolavirus and Andes virus with John Dye (&lt;a title="" href= "https://youtu.be/Vt1r2Yz_AAo?si=B0gzQivIJWL60E-R"&gt;TWiV Special&lt;/a&gt;)&lt;/li&gt; &lt;li&gt;Major &lt;a title="" href= "https://www.science.org/content/article/leading-supplier-research-monkeys-declares-bankruptcy"&gt;research nonhuman primate supplier&lt;/a&gt; going out of business (Science)&lt;/li&gt; &lt;li&gt;&lt;a title="" href= "https://www.nature.com/articles/s41586-026-10453-3"&gt;HIV-1 signalling remodels nuclear pores&lt;/a&gt; to licence infection (Nature)&lt;/li&gt; &lt;li&gt;&lt;a title="" href= "https://www.nature.com/articles/s41565-026-02188-z"&gt;STING agonist nanoparticles&lt;/a&gt; enable mucosal-systemic immunity (Nature Nanoparticles)&lt;/li&gt; &lt;li&gt;Timestamps by &lt;a href= "https://ramseylab.vercel.app/"&gt;Jolene&lt;/a&gt; Ramsey. Thanks!&lt;/li&gt; &lt;/ul&gt; &lt;h3 class="wp-block-heading"&gt;Picks of the Week&lt;/h3&gt; &lt;p&gt;&lt;strong&gt;Brianne &lt;/strong&gt;– &lt;a href= "https://www.sciencenews.org/article/music-from-space-weather-data"&gt;Otherworldly music albums feature space weather data&lt;/a&gt;&lt;br /&gt; &lt;strong&gt;Rich&lt;/strong&gt; – &lt;a href= "https://livingevidence.org.au/research-initiatives/about-feeva/evidence-maps/"&gt;Evidence Mapping: Consolidating and summarising available evidence to support the demonstration of effectiveness of developmental vaccines&lt;/a&gt;, &lt;a href= "https://livingevidence.org.au/"&gt;Australian Living Evidence Collaboration (ALEC)&lt;/a&gt;&lt;br /&gt; &lt;strong&gt;Alan&lt;/strong&gt; – &lt;a href= "https://www.hged.com/community-environment/barrett-fishway/default.aspx"&gt;Holyoke dam fish elevator&lt;/a&gt;&lt;br /&gt; &lt;strong&gt;Vincent&lt;/strong&gt; – &lt;a title="" href= "https://www.nytimes.com/2026/06/11/science/ecology-mycorrhizal-fungus.html?unlocked_article_code=1.rVA.Tw8K.FLgsoHbkolW5&amp;smid=url-share"&gt;68 Quadrillion Underground Miles of Fungi&lt;/a&gt;&lt;/p&gt; &lt;p&gt;Intro music is by &lt;a href= "http://www.ronaldjenkees.com/"&gt;Ronald Jenkees&lt;/a&gt;&lt;/p&gt; &lt;p&gt;Send your virology questions and comments to twiv@microbe.tv&lt;/p&gt; &lt;p&gt;Content in this podcast should not be construed as medical advice.&lt;/p&gt;</description>

This Week in Virology

Vincent Racaniello

TWiV 1333: STING like a nanoparticle, float like HIV

JUN 21, 2026114 MIN
This Week in Virology

TWiV 1333: STING like a nanoparticle, float like HIV

JUN 21, 2026114 MIN

Description

TWiV explains research showing how HIV-1 signalling remodels nuclear pores to licence infection, and development of STING agonist nanoparticles to enable coordinated mucosal-systemic immunity for durable pan-β-coronavirus protection. Hosts: VVincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Positions in Rosenfeld Lab (email) Bundibugyo ebolavirus sitrep (WHO) Ebolavirus and Andes virus with John Dye (TWiV Special) Major research nonhuman primate supplier going out of business (Science) HIV-1 signalling remodels nuclear pores to licence infection (Nature) STING agonist nanoparticles enable mucosal-systemic immunity (Nature Nanoparticles) Timestamps by Jolene Ramsey. Thanks! Picks of the Week Brianne – Otherworldly music albums feature space weather data Rich – Evidence Mapping: Consolidating and summarising available evidence to support the demonstration of effectiveness of developmental vaccines, Australian Living Evidence Collaboration (ALEC) Alan – Holyoke dam fish elevator Vincent – 68 Quadrillion Underground Miles of Fungi Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.