Gavi CEO Sania Nishtar sat down with Katherine E. Bliss, Director and Senior Fellow, Immunizations and Health Systems Resilience, to discuss the Alliance’s ambitious plan of work for the next five years; the ways in which Gavi is reforming to improve efficiencies, promote country ownership and self-sufficiency, overcome resource constraints and meet the geopolitical challenges of the current moment; and how Gavi and other multilateral organizations, including the Global Fund, the World Bank, and CEPI, can better partner with donors, co-financing governments, and the private sector to increase access to lifesaving services, prevent deadly outbreaks, and improve health outcomes for vulnerable populations in low- and lower-middle income countries.