<p>In this episode, Sam Ashoo, MD and Dr. Dana Klavansky, MD discuss the March 2026 Emergency Medicine Practice article, <a href="https://www.ebmedicine.net/topics/trauma/emergency-medicine-severe-traumatic-brain-injury">Emergency Department Evaluation and Management of Severe Traumatic Brain Injury</a></p><p></p><ul><li>Introduction &amp; Welcome (0:15)</li><li>Guest Introduction (0:55)</li><li>Epidemiology of Severe TBI (2:37)</li><li>Pathophysiology: Primary vs. Secondary TBI (4:24)</li><li>Types of Hemorrhage and Hematomas (5:25)</li><li>Classification (7:31)</li><li class="ql-indent-1">Mild vs. Moderate vs. Severe TBI</li><li class="ql-indent-1">Impact Loading vs. Inertial Loading</li><li>Differential Diagnosis (9:22)</li><li>Prehospital Care (9:42)</li><li>Emergency Department History (13:33)</li><li>Diagnostics (15:13)</li><li class="ql-indent-1">CT Scan and the A-B-B-B-C Approach</li><li class="ql-indent-1">Repeat CT Timing</li><li class="ql-indent-1">Bedside Ultrasound for Optic Nerve Sheath Diameter</li><li class="ql-indent-1">Pupillometry</li><li class="ql-indent-1">Biomarkers</li><li>Treatment (24:52)</li><li class="ql-indent-1">Airway Management</li><li class="ql-indent-1">Ventilation and CO2 Targets</li><li class="ql-indent-1">Hyperosmolar Therapy: Hypertonic Saline and Mannitol</li><li class="ql-indent-1">Cerebral Perfusion Pressure</li><li class="ql-indent-1">Blood Pressure Goals</li><li class="ql-indent-1">Temperature Management</li><li class="ql-indent-1">Coagulopathy Management</li><li class="ql-indent-1">Seizure Prophylaxis and EEG Monitoring</li><li>Tiered ICP Management (35:29)</li><li>Surgical Indications (38:40)</li><li>Prognosis (40:33)</li><li>Special Topics (41:30)</li><li class="ql-indent-1">Sports Injuries and CTE</li><li class="ql-indent-1">Tranexamic Acid (CRASH-3 Trial)</li><li>Wrap-Up (43:46)</li></ul><p></p><p>Subscribers, take the CME test <a href="https://www.ebmedicine.net/cme/trauma/emergency-medicine-severe-traumatic-brain-injury">here</a>. </p><p></p><p>Emergency Medicine Residents, get your free subscription by writing [email protected]</p>