BetterHealthGuy Podcast

🎧 Episode Summary This episode continues the conversation with Dayan Goodenowe, PhD, exploring the shared biochemical patterns underlying conditions such as autism, PANS/PANDAS, chronic Lyme, mold illness, Alzheimer's, Parkinson's, MS, and ALS. The discussion examines how environmental stressors, metabolic and lipid dysfunction, and oxidative stress contribute to loss of resilience and disease progression. Dr. Goodenowe also highlights the role of biomarkers, advanced testing, and targeted support—including plasmalogens and methylation—in identifying prodromes and restoring function across complex chronic conditions. 🧭 In This Episode - Similarities and differences across autism, PANS/PANDAS, chronic Lyme, mold illness, Alzheimer's disease, Parkinson's disease, Multiple Sclerosis, and ALS - Prodromes as loss of resilience and early deviation from health - Aging as entropy and biochemical insufficiency rather than a programmed disease process - Metabolic sufficiency, mitochondrial function, and lipid membrane integrity as core systems in adaptation - Oxidative stress, inflammatory markers, and reserve capacity in chronic illness - ProdromeScan and BioMetrix Bioscan differences in scope, interpretation, and monitoring - Standard biomarkers associated with compromised peroxisomal function and low plasmalogens - NAD, niacin, spermidine, and urolithin A in relation to mitochondrial and cellular function - Alzheimer's disease mechanisms involving DHA plasmalogen depletion, amyloid formation, acetylcholine dysfunction, and methyltransferase stress - Phosphatidylcholine and dietary choline as support for acetylcholine production and membrane health - Brain volumetrics, cortical thickness, white matter density, and advanced MRI measures of structural recovery - Traumatic brain injury, concussion recovery, and plasmalogen support for gray matter, white matter, and blood flow - Methyltransferase system support with methyl B12, methylfolate, trimethylglycine, N-acetylcysteine, phosphatidylcholine, and creatine - Long COVID, mitochondrial dysfunction, chronic inflammation, brain fog, and myocarditis - ME/CFS, chronic Lyme disease, and mold illness through the lens of mitochondrial load, restoration, and resilience - Autism and PANS/PANDAS as neuroinflammatory and developmental conditions involving white matter integrity and plasmalogen support 👤 About the Guest Dayan Goodenowe, PhD, is a neuroscientist, biochemist, inventor, and clinical research expert. In 1999, he invented and patented ion cyclotron resonance mass spectrometry technology, enabling comprehensive monitoring of human biochemistry for the first time. Using this technology, Dr. Goodenowe analyzed blood samples from tens of thousands of individuals of all ages and races, from multiple countries. The biochemistry of healthy individuals was compared with that of individuals experiencing a wide range of diseases. Over 20 conditions were studied, including autism, dementia, colon cancer, heart disease, and others. Differences between the biochemistry of younger and older populations, as well as associations with all-cause mortality, were also examined. This body of research identified early biochemical patterns associated with disease and mortality risk, thereby contributing to the development of an extensive patent portfolio. These patents cover diagnostic tests for early detection and screening across numerous conditions, including specific cancers, neurological disorders, psychiatric conditions, and cardiovascular disease. Dr. Goodenowe is also the author of Breaking Alzheimer's, which documents his research journey and examines the biochemical findings that informed his work in neurodegeneration and lipid biology. Connect With the Guest Website - https://drgoodenowe.com YouTube - https://www.youtube.com/@Dr.Goodenowe Facebook - https://www.facebook.com/drdayangoodenowe Instagram - https://www.instagram.com/drdayangoodenowe X - https://twitter.com/DrGoodenowe TikTok - https://www.tiktok.com/@drdayangoodenowe Interview Date: April 13, 2026 🔗 Related Resources Prodrome Science Plasmalogens - https://betterhealthguy.link/Prodrome Use code BETTERHEALTH for 25% off EP230: Lipid Biology, Plasmalogens, and Neurodegenerative Prodromes - Part 1 - Dayan Goodenowe, PhD - https://www.betterhealthguy.com/ep230 Part 1 of this conversation with Dayan Goodenowe, PhD Affiliate Disclosure: Some links on this page (including guest and resource links) may provide a discount for you and a small commission for me at no additional cost to you. 📄 Transcript Review a transcript of this episode: https://betterhealthguy.com/ep231 ☕ Support the Show Support the show and Buy Me a Coffee: https://betterhealthguy.link/BuyMeACoffee 🧭 My 16-Step Framework Learn more about my 16-Step Framework for better health: https://betterhealthguy.link/Steps 💸 Community Discounts Explore BetterHealthGuy Community Discounts: https://betterhealthguy.link/Discounts 🌐 Additional Information Learn more: https://BetterHealthGuy.com 📱 Connect With Me Facebook - https://facebook.com/betterhealthguy Instagram - https://instagram.com/betterhealthguy X - https://twitter.com/betterhealthguy TikTok - https://tiktok.com/@betterhealthguy ℹ️ Disclaimer The content of this show is for informational purposes only and is not intended to diagnose, treat, or cure any illness or medical condition. Nothing in today's discussion is meant to serve as medical advice or as information to facilitate self-treatment. As always, please discuss any potential health-related decisions with your own personal medical authority.

🎧 Episode Summary This episode explores the foundational role of lipid biology and plasmalogens in cellular health, inflammation, and neurodegenerative patterns. Dayan Goodenowe, PhD discusses how membrane composition, oxidative stress, and environmental factors influence cellular function, along with the potential impact of plasmalogen precursor therapies on cognition, resilience, and overall system regulation. 🧭 In This Episode - Lipid membrane composition differences across cell types and organelles - Phospholipid bilayer structure and hydrophilic–hydrophobic organization - Functional role of membrane lipids in cellular compartmentalization - Variability of lipid composition within different regions of a single cell - Impact of oxidative stress on membrane lipid composition and function - Mechanism of phospholipid peroxidation and phospholipase-mediated removal - Relationship between membrane rigidity and cellular signaling capacity - Mitochondrial dysfunction and its role in the Cell Danger Response - Nutrient and cofactor requirements for mitochondrial energy production - Interaction between membrane lipid integrity and mitochondrial performance - Immune activation triggered by peroxidized membrane lipids - Functional differences between omega-9 and omega-3 plasmalogen precursors - Role of plasmalogens in synaptic transmission and neurotransmitter release 👤 About the Guest Dayan Goodenowe, PhD, is a neuroscientist, biochemist, inventor, and clinical research expert. In 1999, he invented and patented ion cyclotron resonance mass spectrometry technology, enabling comprehensive monitoring of human biochemistry for the first time. Using this technology, Dr. Goodenowe analyzed blood samples from tens of thousands of individuals of all ages and races, from multiple countries. The biochemistry of healthy individuals was compared with that of individuals experiencing a wide range of diseases. Over 20 conditions were studied, including autism, dementia, colon cancer, heart disease, and others. Differences between the biochemistry of younger and older populations, as well as associations with all-cause mortality, were also examined. This body of research identified early biochemical patterns associated with disease and mortality risk, thereby contributing to the development of an extensive patent portfolio. These patents cover diagnostic tests for early detection and screening across numerous conditions, including specific cancers, neurological disorders, psychiatric conditions, and cardiovascular disease. Dr. Goodenowe is also the author of Breaking Alzheimer's, which documents his research journey and examines the biochemical findings that informed his work in neurodegeneration and lipid biology. Connect With the Guest Website - https://drgoodenowe.com YouTube - https://www.youtube.com/@Dr.Goodenowe Facebook - https://www.facebook.com/drdayangoodenowe Instagram - https://www.instagram.com/drdayangoodenowe X - https://twitter.com/DrGoodenowe TikTok - https://www.tiktok.com/@drdayangoodenowe Interview Date: March 24, 2026 🔗 Related Resources Prodrome Science Plasmalogens - https://betterhealthguy.link/Prodrome Use code BETTERHEALTH for 25% off Affiliate Disclosure: Some links on this page (including guest and resource links) may provide a discount for you and a small commission for me at no additional cost to you. 📄 Transcript Review a transcript of this episode: https://betterhealthguy.com/ep230 ☕ Support the Show Support the show and Buy Me a Coffee: https://betterhealthguy.link/BuyMeACoffee 🧭 My 16-Step Framework Learn more about my 16-Step Framework for better health: https://betterhealthguy.link/Steps 💸 Community Discounts Explore BetterHealthGuy Community Discounts: https://betterhealthguy.link/Discounts 🌐 Additional Information Learn more: https://BetterHealthGuy.com 📱 Connect With Me Facebook - https://facebook.com/betterhealthguy Instagram - https://instagram.com/betterhealthguy X - https://twitter.com/betterhealthguy TikTok - https://tiktok.com/@betterhealthguy ℹ️ Disclaimer The content of this show is for informational purposes only and is not intended to diagnose, treat, or cure any illness or medical condition. Nothing in today's discussion is meant to serve as medical advice or as information to facilitate self-treatment. As always, please discuss any potential health-related decisions with your own personal medical authority.

Why You Should Listen: In this episode, you will learn about the role of Supportive Oligonucleotide Therapy, or SOT, in the treatment of Lyme disease and vector-borne infections. About My Guest: My guest for this episode is Dr. Clayton Bell. Clayton Bell, MD is a leading integrative and functional medicine physician dedicated to helping patients achieve deep, lasting wellness. Dr. Bell works with Lyme and vector-borne infections, integrative cancer support, environmental medicine including mold, mycotoxins, heavy metals, and detoxification; hormones, cardiometabolic and GI health, and mind-body balance. Combining his Western medical training with functional, integrative, environmental, and Ayurvedic approaches, he focuses on uncovering the root causes of health concerns. Patients benefit from personalized, whole-person treatment plans that empower the body's natural healing ability and support sustainable wellness from the inside out. Dr. Bell provides online consultations that offer accessible, holistic care tailored to each individual's needs. Key Takeaways: What place does SOT have in the treatment arsenal for chronic Lyme disease? What is AOT or Antisense Oligonucleotide Therapy? What testing is acceptable for a practitioner to request an SOT for a patient? What testing is offered by Biocentaur? How does SOT work in the body? How does the practitioner determine which SOT to request when many infections may be positive? What SOTs are available for vector-borne infections and viruses? What are the foundational steps to prepare a patient for an SOT? Do certain therapies need to be stopped before testing and while doing SOT? How important is immune modulation or creating immune tolerance to the microbes? What is the SOT administration process? How are Herxheimer reactions addressed with using SOT? Can the SOT push back one infection and then lead to another becoming the dominant focus of the immune system and symptom presentation? How long should there be between SOTs? Is there a maximum number of SOTs that can be done? Can SOT reach all potential reservoirs of infection in the body? What role do biofilms play in the context of SOT? Have any specific SOTs been helpful in the contents of EDS, PANS/PANDAS, or Long COVID? What role might SOT play in neurodegenerative conditions? Can SOT resolve autoimmunity, inflammation, or oxidative stress? When SOT does not appear to work, how does the practitioner troubleshoot potential reasons? - What is the cost of SOT? Connect With My Guest: MetaMedical.life DrClaytonBell.com Related Resources: RGCC North America RGCC International RGCC Vector-Borne and Virus SOTs available RGCC Provider Map Interview Date: February 24, 2026 Transcript: To review a transcript of this show, visit https://BetterHealthGuy.com/Episode229. Support the Show: To support the show and Buy Me a Coffee, visit https://betterhealthguy.link/BuyMeACoffee. Additional Information: To learn more, visit https://BetterHealthGuy.com. Follow Me on Social Media: Facebook - https://facebook.com/betterhealthguy Instagram - https://instagram.com/betterhealthguy X - https://twitter.com/betterhealthguy TikTok - https://tiktok.com/@betterhealthguy Disclaimer: The content of this show is for informational purposes only and is not intended to diagnose, treat, or cure any illness or medical condition. Nothing in today's discussion is meant to serve as medical advice or as information to facilitate self-treatment. As always, please discuss any potential health-related decisions with your own personal medical authority.

Why You Should Listen: In this episode, you will learn about the role of Body Ecology in Candida, Long COVID, viral illness, and autism. About My Guest: My guest for this episode is Donna Gates. Donna Gates, MEd, ABAAHP is a pioneer in gut health, infections, and immunity. Decades before it became mainstream, she was the first to teach about the extraordinary and complex world inside the gut, now known as the microbiome, and how it influences immunity, brain health, metabolism, and long-term wellness. She is the founder of Body Ecology, a revolutionary system that introduced the first gluten-free, sugar-free, and dairy-free nutritional approaches, with a strategic focus on specific fermented foods to create a thriving inner ecosystem in the gut. In her bestselling book, "The Body Ecology Diet", which has remained relevant for decades, Donna explains how to conquer Candida, restore microbial balance, and rebuild the immune system. She reveals how the inner ecosystem is established at birth and how this process represents nature's original form of building a vibrant immune system. By partnering with nature, rather than attempting to override it, we build true immune resilience, even in a toxic world where pathogens are a constant threat. Her newest book, "Taming the Dragon: Body Ecology's Guide to Preventing and Treating Viral Infections", offers practical solutions for persistent viral illness, immune dysfunction, and long-haulers. Key Takeaways: What is the Body Ecology diet? What strategies can support optimizing Candida and the inner ecosystem? Can fermented foods be used in those with MCAS? How are conditions such as SIBO and SIFO approached? What was Donna's personal journey with Long COVID? What tools has Donna found helpful for regaining her health after COVID? How did SOT help Donna move past Lyme disease? What is the impact of spike proteins and how might they be mitigated? How can vascular health be optimized in the era of COVID? What strategies can support a robust immune system and minimize immunosenescence as people age? What role do chronic viruses have on health? Is it more important to boost or to modulate the immune system? How does the Cell Danger Response fit into the chronic illness discussion? What are some strategies for supporting the vagus nerve? What dietary changes are important when dealing with a viral condition? How do acidity and alkalinity play a role? What are some strategies for supporting detoxification? What has Donna seen over many years of working with children with autism? What is the Epigenetic Reset? Connect With My Guest: BodyEcology.com Related Resources: Book - Taming the Dragon: Body Ecology's Guide to Preventing and Defeating Viral Infections An Antiviral Diet Interview Date: January 29, 2026 Transcript: To review a transcript of this show, visit https://BetterHealthGuy.com/Episode228. Support the Show: To support the show and Buy Me a Coffee, visit https://betterhealthguy.link/BuyMeACoffee. Additional Information: To learn more, visit https://BetterHealthGuy.com. Follow Me on Social Media: Facebook - https://facebook.com/betterhealthguy Instagram - https://instagram.com/betterhealthguy X - https://twitter.com/betterhealthguy TikTok - https://tiktok.com/@betterhealthguy Disclaimer: The content of this show is for informational purposes only and is not intended to diagnose, treat, or cure any illness or medical condition. Nothing in today's discussion is meant to serve as medical advice or as information to facilitate self-treatment. As always, please discuss any potential health-related decisions with your own personal medical authority.

Why You Should Listen: In this episode, you will discover how addressing parasites and dental issues can unlock better health and why real healing is rarely an Accidental Cure. About My Guest: My guest for this episode is Dr. Simon Yu. Simon Yu, MD combines internal medicine with integrative medicine at Prevention and Healing, Inc., in St. Louis, MO. As an HMO regional medical director, he saw the limits of a medication-management approach to patients with complex chronic illness. He studied integrative and biological medicine, took 300 hours of medical acupuncture training, and researched dental, fungal, and parasite problems. He served as a medical officer in the U.S. Army Reserve for 25 years, retiring as a full colonel. Dr. Yu lectures in the US and abroad. He offers Acupuncture Meridian Assessment (AMA) Training to help detect problems for doctors and dentists in St. Louis and in Germany. He has an MD from the University of Missouri School of Medicine, has an MS in Immunology, is certified by the American Board of Internal Medicine, a member of American College of Physicians, and is on the advisory board of the International College of Integrative Medicine. Key Takeaways: Where does Artificial Intelligence fit in addressing complex, chronic illnesses? What are the more common patterns of meridian dysregulation observed? How are most parasites acquired? Are parasites always bad for the body? What are the more common medications used to address parasites? Does mold in the external environment impact parasite treatment or dental interventions? Are all parasites that impact health physical? How is the treatment of fungal issues approached? Should patients test their home for mold? What types of dental issues are most commonly impacting patients? How does testing for the DNA of oral pathogens inform treatment? What long-term oral hygiene strategies may be helpful? Are implants appropriate after an extraction? How has treating complex patients changed with COVID? Is spike protein detoxification now part of the healing approach? Do EMFs negatively impact health? Are conditions such as Ehlers-Danlos Syndrome and Morgellons approached differently? What are some top detoxification strategies? Is "autoimmunity" the result of chronic infections? What is the best approach for optimizing the microbiome? What are some of the emerging treatment interventions from SOZO Brain Clinic? Connect With My Guest: PreventionAndHealing.com Related Resources: Book - Accidental Cure 3: AI vs. Ancient Intelligence Interview Date: January 7, 2026 Transcript: To review a transcript of this show, visit https://BetterHealthGuy.com/Episode227. Support the Show: To support the show and Buy Me a Coffee, visit https://betterhealthguy.link/BuyMeACoffee. Additional Information: To learn more, visit https://BetterHealthGuy.com. Follow Me on Social Media: Facebook - https://facebook.com/betterhealthguy Instagram - https://instagram.com/betterhealthguy X - https://twitter.com/betterhealthguy TikTok - https://tiktok.com/@betterhealthguy Disclaimer: The content of this show is for informational purposes only and is not intended to diagnose, treat, or cure any illness or medical condition. Nothing in today's discussion is meant to serve as medical advice or as information to facilitate self-treatment. As always, please discuss any potential health-related decisions with your own personal medical authority.