It is estimated that more than 30% of people do not respond to medicines to treat depression. This can leave people with limited treatment options and have a huge impact on their quality of life and their support networks. A panel of Queensland Brain Institute (QBI) experts, Dr Susannah Tye, Dr Dhanisha Jhaveri and psychiatrist Dr Philip Mosley explore the neuroscience of depression, its impact on society, and how research can help pave a successful path into the future.