In this episode of Hot Topics, Dr. Nicholas Morris interviews <a href= "https://fr.linkedin.com/in/claire-dahyot-fizelier-10272822b/en?trk=public_post_feed-actor-name"> Claire Dahyot-Fizelier, M.D,</a> <a href= "https://fr.linkedin.com/in/claire-dahyot-fizelier-10272822b/en?trk=public_post_feed-actor-name"> Ph.D.</a><a href= "https://fr.linkedin.com/in/claire-dahyot-fizelier-10272822b/en?trk=public_post_feed-actor-name">,</a> a professor of anesthesia and intensive care at the University of Poitiers, to explore the groundbreaking PROPHY-VAP trial published in The Lancet Respiratory Medicine. This landmark study investigates the impact of single-dose ceftriaxone prophylaxis on ventilator-associated pneumonia (VAP) in acute brain injury patients. Dr. Dahyot-Fizelier discusses the rationale behind the study, key findings and the broader implications for ICU practices. Tune in to discover how this trial could reshape approaches to infection prevention and improve patient outcomes in neurocritical care. Show notes: <a href= "https://doi.org/10.1016/S2213-2600(23)00471-X">https://doi.org/10.1016/S2213-2600(23)00471-X</a> Dahyot-Fizelier C, Lasocki S, Kerforne T, Perrigault PF, Geeraerts T, Asehnoune K, Cinotti R, Launey Y, Cottenceau V, Laffon M, Gaillard T, Boisson M, Aleyrat C, Frasca D, Mimoz O, on behalf of the PROPHY-VAP Study Group and the ATLANREA Study Group. Ceftriaxone to prevent early ventilator-associated pneumonia in patients with acute brain injury: a multicentre, randomised, double-blind, placebo-controlled, assessor-masked superiority trial. The Lancet Respiratory Medicine. 2024 May 1;12(5):375-85.

<description>&lt;p class="MsoNormal" style="margin: 12.0pt 0in 12.0pt 0in;"&gt; &lt;span lang="EN" xml:lang="EN"&gt;In this episode of &lt;em style= "mso-bidi-font-style: normal;"&gt;Hot Topics&lt;/em&gt;, Dr. Nicholas Morris interviews &lt;strong&gt;&lt;u&gt;&lt;span style="color: #1155cc;"&gt;&lt;a href= "https://fr.linkedin.com/in/claire-dahyot-fizelier-10272822b/en?trk=public_post_feed-actor-name"&gt; Claire Dahyot-Fizelier, M.D,&lt;/a&gt;&lt;/span&gt;&lt;/u&gt; &lt;u&gt;&lt;span style= "color: #1155cc;"&gt;&lt;a href= "https://fr.linkedin.com/in/claire-dahyot-fizelier-10272822b/en?trk=public_post_feed-actor-name"&gt; Ph.D.&lt;/a&gt;&lt;/span&gt;&lt;/u&gt;&lt;/strong&gt;&lt;strong style= "mso-bidi-font-weight: normal;"&gt;&lt;u&gt;&lt;span style= "color: #1155cc;"&gt;&lt;a href= "https://fr.linkedin.com/in/claire-dahyot-fizelier-10272822b/en?trk=public_post_feed-actor-name"&gt;&lt;span style="font-weight: normal;"&gt;,&lt;/span&gt;&lt;/a&gt;&lt;/span&gt;&lt;/u&gt;&lt;/strong&gt; a professor of anesthesia and intensive care at the University of Poitiers, to explore the groundbreaking PROPHY-VAP trial published in &lt;em style="mso-bidi-font-style: normal;"&gt;The Lancet Respiratory Medicine&lt;/em&gt;. This landmark study investigates the impact of single-dose ceftriaxone prophylaxis on ventilator-associated pneumonia (VAP) in acute brain injury patients. Dr. Dahyot-Fizelier discusses the rationale behind the study, key findings and the broader implications for ICU practices. Tune in to discover how this trial could reshape approaches to infection prevention and improve patient outcomes in neurocritical care.&lt;/span&gt;&lt;/p&gt; &lt;p class="MsoNormal" style="margin: 12.0pt 0in 12.0pt 0in;"&gt; &lt;span lang="EN" xml:lang="EN"&gt;Show notes:&lt;/span&gt;&lt;/p&gt; &lt;p class="MsoNormal" style="margin: 12.0pt 0in 12.0pt .5in;"&gt; &lt;span lang="EN" xml:lang="EN"&gt;&lt;a href= "https://doi.org/10.1016/S2213-2600(23)00471-X"&gt;&lt;span style= "color: #1155cc;"&gt;https://doi.org/10.1016/S2213-2600(23)00471-X&lt;/span&gt;&lt;/a&gt;&lt;/span&gt;&lt;/p&gt; &lt;p class="MsoNormal" style="margin: 12.0pt 0in 12.0pt .5in;"&gt; &lt;span lang="EN" xml:lang="EN"&gt;Dahyot-Fizelier C, Lasocki S, Kerforne T, Perrigault PF, Geeraerts T, Asehnoune K, Cinotti R, Launey Y, Cottenceau V, Laffon M, Gaillard T, Boisson M, Aleyrat C, Frasca D, Mimoz O, on behalf of the PROPHY-VAP Study Group and the ATLANREA Study Group. Ceftriaxone to prevent early ventilator-associated pneumonia in patients with acute brain injury: a multicentre, randomised, double-blind, placebo-controlled, assessor-masked superiority trial. &lt;em&gt;The Lancet Respiratory Medicine&lt;/em&gt;. 2024 May 1;12(5):375-85.&lt;/span&gt;&lt;/p&gt;</description>

A Conversation With Dr. Claire Dahyot-Fizelier

HOT TOPICS: The PROPHY-VAP Study

In this episode of Hot Topics, Dr. Nicholas Morris interviews Dr. Giuseppe Citerio, professor of anesthesia and intensive care at Milano-Bicocca University, about the ORANGE study, which investigated the neurological pupil index (NPI) for prognosticating outcomes in patients with acute brain injury. The study, involving 13 centers in Europe and North America, found that repeat abnormal NPI values, including zero, were predictors of poor outcomes. The study collected data every four hours for seven days and used a sophisticated statistical model to account for longitudinal changes. Despite initial expectations, the study did not find a strong correlation between the NPI and ICP, suggesting NPI should not be used as a surrogate for ICP. Future research may focus on developing a standardized response to low NPI values. Show Notes: <a href= "https://doi.org/10.1016/S1474-4422(23)00271-5">https://doi.org/10.1016/S1474-4422(23)00271-5</a> Oddo M, Taccone FS, Petrosino M, Badenes R, Blandino-Ortiz A, Bouzat P, Caricato A, Chesnut RM, Feyling AC, Ben-Hamouda N, Hemphill JC. The Neurological Pupil index for outcome prognostication in people with acute brain injury (ORANGE): a prospective, observational, multicentre cohort study. The Lancet Neurology. 2023 Oct 1;22(10):925-33.

<description>&lt;p class="MsoNormal"&gt;In this episode of &lt;em&gt;Hot Topics&lt;/em&gt;, Dr. Nicholas Morris interviews Dr. Giuseppe Citerio, professor of anesthesia and intensive care at Milano-Bicocca University, about the ORANGE study, which investigated the neurological pupil index (NPI) for prognosticating outcomes in patients with acute brain injury. The study, involving 13 centers in Europe and North America, found that repeat abnormal NPI values, including zero, were predictors of poor outcomes. The study collected data every four hours for seven days and used a sophisticated statistical model to account for longitudinal changes. Despite initial expectations, the study did not find a strong correlation between the NPI and ICP, suggesting NPI should not be used as a surrogate for ICP. Future research may focus on developing a standardized response to low NPI values.&lt;/p&gt; &lt;p class="MsoNormal"&gt;Show Notes:&lt;/p&gt; &lt;p class="MsoNormal" style="margin-left: .5in;"&gt;&lt;a href= "https://doi.org/10.1016/S1474-4422(23)00271-5"&gt;https://doi.org/10.1016/S1474-4422(23)00271-5&lt;/a&gt;&lt;/p&gt; &lt;p class="MsoNormal" style="margin-left: .5in;"&gt;Oddo M, Taccone FS, Petrosino M, Badenes R, Blandino-Ortiz A, Bouzat P, Caricato A, Chesnut RM, Feyling AC, Ben-Hamouda N, Hemphill JC. The Neurological Pupil index for outcome prognostication in people with acute brain injury (ORANGE): a prospective, observational, multicentre cohort study. The Lancet Neurology. 2023 Oct 1;22(10):925-33.&lt;/p&gt;</description>

In this episode of Hot Topics, Dr. Nicholas Morris interviews Dr. Giuseppe Citerio, professor of anesthesia and intensive care at Milano-Bicocca University, about the ORANGE study, which investigated the neurological pupil index (NPI) for...

HOT TOPICS: The ORANGE Study With Dr. Giuseppe Citerio

On September 2022, Cameron Kuklick fell from a motorized rental scooter while returning to his hotel after celebrating his brother’s wedding in Harrisonburg, Virginia. Cameron experienced a severe traumatic brain injury (TBI) at the age of 30. Cameron and his family hope that by sharing their story and experiences, they too can provide hope and healing for others. In this week’s episode, Cameron joins Dr. Lauren Koffman and Dea Mahanes, DNP, APRN, CCNS, HEC-C, FNCS, who was on Cameron's care team, to discuss his Story of Hope. You can read Cameron's story in Currents at <a href= "https://currents.neurocriticalcare.org/Stories-of-Hope/Article/unbroken-stride-camerons-story-of-hope-overcoming-brain-injury-to-cross-the-finish-line" target="_blank" rel= "noopener">https://currents.neurocriticalcare.org/Stories-of-Hope/Article/unbroken-stride-camerons-story-of-hope-overcoming-brain-injury-to-cross-the-finish-line</a>.

<description>&lt;p class="MsoNormal"&gt;On September 2022, Cameron Kuklick fell from a motorized rental scooter while returning to his hotel after celebrating his brother’s wedding in Harrisonburg, Virginia. Cameron experienced a severe traumatic brain injury (TBI) at the age of 30. Cameron and his family hope that by sharing their story and experiences, they too can provide hope and healing for others. &lt;span lang="EN-US" xml:lang="EN-US"&gt;In this week’s episode, Cameron joins Dr. Lauren Koffman and Dea Mahanes, DNP, APRN, CCNS, HEC-C, FNCS, who was on Cameron's care team, to discuss his Story of Hope.&lt;/span&gt;&lt;/p&gt; &lt;p class="MsoNormal"&gt;&lt;span lang="EN-US" xml:lang="EN-US"&gt;You can read Cameron's story in &lt;em&gt;Currents&lt;/em&gt; at &lt;a href= "https://currents.neurocriticalcare.org/Stories-of-Hope/Article/unbroken-stride-camerons-story-of-hope-overcoming-brain-injury-to-cross-the-finish-line" target="_blank" rel= "noopener"&gt;https://currents.neurocriticalcare.org/Stories-of-Hope/Article/unbroken-stride-camerons-story-of-hope-overcoming-brain-injury-to-cross-the-finish-line&lt;/a&gt;.&lt;/span&gt;&lt;/p&gt;</description>

Overcoming Brain Injury to Cross the Finish Line

CURRENTS: Unbroken Stride: Cameron’s Story of Hope

In this week's episode of Perspectives, Dr Nicholas Morris is joined by NCS Past President, Dr Gretchen Brophy, Professor of Pharmacotherapy & Outcomes Sciences and Neurosurgery with Virginia Commonwealth University (VCU) School of Pharmacy, Medical College of Virginia Campus, in Richmond.

<description>&lt;p&gt;In this week's episode of &lt;em&gt;Perspectives&lt;/em&gt;, Dr Nicholas Morris is joined by NCS Past President, Dr Gretchen Brophy, Professor of Pharmacotherapy &amp; Outcomes Sciences and Neurosurgery with Virginia Commonwealth University (VCU) School of Pharmacy, Medical College of Virginia Campus, in Richmond.&lt;/p&gt;</description>

In this week's episode of Perspectives, Dr Nicholas Morris is joined by NCS Past President, Dr Gretchen Brophy, Professor of Pharmacotherapy & Outcomes Sciences and Neurosurgery with Virginia Commonwealth University (VCU) School of Pharmacy,...

PERSPECTIVES: Dr Gretchen Brophy

Electroencephalography (EEG) is an important and relatively inexpensive tool that allows intensivists to monitor cerebral activity of critically ill patients in real time. Seizure detection in patients with and without acute brain injury is the primary reason to obtain an EEG in the Intensive Care Unit (ICU); and in response to the increased demand for EEG, advances in quantitative EEG (qEEG) created an approach to review large amounts of data instantly. Today, rapid response EEG is now available to reduce the time to detect electrographic seizures in limited-resource settings. In this week's MasterClass, our hosts Dr Jon Rosenberg and Dr Stephan Mayer are joined by Dr Lawerence Hirsch, Co-Director of the Critical Care EEG Monitoring Program at Yale School of Medicine to discuss the evolution, value, and impact of brain monitoring with EEG in the critically ill.

<description>&lt;p&gt;Electroencephalography (EEG) is an important and relatively inexpensive tool that allows intensivists to monitor cerebral activity of critically ill patients in real time. Seizure detection in patients with and without acute brain injury is the primary reason to obtain an EEG in the Intensive Care Unit (ICU); and in response to the increased demand for EEG, advances in quantitative EEG (qEEG) created an approach to review large amounts of data instantly. Today, rapid response EEG is now available to reduce the time to detect electrographic seizures in limited-resource settings. In this week's MasterClass, our hosts Dr Jon Rosenberg and Dr Stephan Mayer are joined by Dr Lawerence Hirsch, Co-Director of the Critical Care EEG Monitoring Program at Yale School of Medicine to discuss the evolution, value, and impact of brain monitoring with EEG in the critically ill. &lt;/p&gt;</description>

Electroencephalography (EEG) is an important and relatively inexpensive tool that allows intensivists to monitor cerebral activity of critically ill patients in real time. Seizure detection in patients with and without acute brain injury is the...

MASTERCLASS: Critical Care EEG Monitoring

The goal of the Neurocritical Care Society Podcast is to summarize some of the latest content and cutting edge research published in the journal, Neurocritical Care, official journal of the Neurocritical Care Society. Episodes are produced regularly and feature interviews with the top researchers around the world in the fields of neurology, critical care, and neurosurgery.

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