The latest episode of Thinking Thoracic dives into one of the most challenging diseases in thoracic oncology—malignant pleural mesothelioma. Host Erin Gillaspie, MD, speaks with Joshua Reuss, MD, a thoracic medical oncologist and clinical trials leader, about how immunotherapy, evolving surgical strategies, and global practice patterns are reshaping care for this rare cancer. The episode covers the impact of the Checkmate 743 trial, controversy surrounding the MARS-2 surgical study, promising results from neoadjuvant immunotherapy trials, and the critical need for collaboration and clinical trial enrollment to drive progress. Listen now to explore where mesothelioma research is headed and what it means for patient care.