Why do some people feel trapped in sadness, while others lose their sense of motivation and purpose? In this episode of Road to Resilience, host Stephen Calabria speaks with Dr. Martijn Figee about the brain science behind depression, resilience, and emotional recovery. A leader in the study of deep brain stimulation and psychiatric neuromodulation, Dr. Figee explains how different brain circuits govern mood, reward, stress, and motivation—and how understanding those systems may reshape the future of mental health care. Along the way, he offers practical insights into mindfulness, behavioral activation, social connection, and the everyday habits that help keep the brain healthy and resilient. Visit https://www.mountsinai.org/clinical-trials to see if you're eligible to enroll in a clinical trial with the Mount Sinai Health System.Check out more episodes of Road to Resilience —as well as guest pictures, transcripts, and more— on the Mount Sinai website.Road to Resilience brings you stories and insights to help you thrive in a challenging world. From fighting burnout and trauma to building resilient families, we explore what’s possible when science meets the human spirit.