<description>&lt;p class="MsoNormal"&gt;&lt;span style= "mso-fareast-font-family: 'Times New Roman'; color: black;"&gt;What is silica? How does it impact your risk of developing autoimmunity if you inhale it, inject it or even snort it up your nose? Listen and find out!&lt;/span&gt;&lt;/p&gt; &lt;p class="MsoListParagraphCxSpFirst" style= "text-indent: -.25in; line-height: 106%; mso-list: l0 level1 lfo1;"&gt; &lt;!-- [if !supportLists]--&gt;&lt;span style= "font-family: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol;"&gt;&lt;span style="mso-list: Ignore;"&gt;·&lt;span style="font: 7.0pt 'Times New Roman';"&gt;      &lt;/span&gt;&lt;/span&gt;&lt;/span&gt; &lt;!--[endif]--&gt;Intro &lt;strong style= "mso-bidi-font-weight: normal;"&gt;&lt;em style= "mso-bidi-font-style: normal;"&gt;0:12&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoListParagraphCxSpMiddle" style= "text-indent: -.25in; line-height: 106%; mso-list: l0 level1 lfo1;"&gt; &lt;!-- [if !supportLists]--&gt;&lt;span style= "font-family: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol; mso-bidi-font-style: italic;"&gt;&lt;span style="mso-list: Ignore;"&gt;·&lt;span style="font: 7.0pt 'Times New Roman';"&gt;      &lt;/span&gt;&lt;/span&gt;&lt;/span&gt; &lt;!--[endif]--&gt;In the previous episodes &lt;strong&gt;&lt;em&gt;0:28&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoListParagraphCxSpMiddle" style= "text-indent: -.25in; line-height: 106%; mso-list: l0 level1 lfo1;"&gt; &lt;!-- [if !supportLists]--&gt;&lt;span style= "font-family: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol; mso-bidi-font-style: italic;"&gt;&lt;span style="mso-list: Ignore;"&gt;·&lt;span style="font: 7.0pt 'Times New Roman';"&gt;      &lt;/span&gt;&lt;/span&gt;&lt;/span&gt; &lt;!--[endif]--&gt;The Ajax incident of 1979 &lt;strong&gt;&lt;em&gt;1:15&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoListParagraphCxSpMiddle" style= "text-indent: -.25in; line-height: 106%; mso-list: l0 level1 lfo1;"&gt; &lt;!-- [if !supportLists]--&gt;&lt;span style= "font-family: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol; mso-bidi-font-style: italic;"&gt;&lt;span style="mso-list: Ignore;"&gt;·&lt;span style="font: 7.0pt 'Times New Roman';"&gt;      &lt;/span&gt;&lt;/span&gt;&lt;/span&gt; &lt;!--[endif]--&gt;Silica and its association with autoimmune disease &lt;strong&gt;&lt;em&gt;4:11&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoListParagraphCxSpMiddle" style= "text-indent: -.25in; line-height: 106%; mso-list: l0 level1 lfo1;"&gt; &lt;!-- [if !supportLists]--&gt;&lt;span style= "font-family: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol; mso-bidi-font-style: italic;"&gt;&lt;span style="mso-list: Ignore;"&gt;·&lt;span style="font: 7.0pt 'Times New Roman';"&gt;      &lt;/span&gt;&lt;/span&gt;&lt;/span&gt; &lt;!--[endif]--&gt;The history of silica and the health risks &lt;strong&gt;&lt;em&gt;5:21&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoListParagraphCxSpMiddle" style= "text-indent: -.25in; line-height: 106%; mso-list: l0 level1 lfo1;"&gt; &lt;!-- [if !supportLists]--&gt;&lt;span style= "font-family: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol; mso-bidi-font-style: italic;"&gt;&lt;span style="mso-list: Ignore;"&gt;·&lt;span style="font: 7.0pt 'Times New Roman';"&gt;      &lt;/span&gt;&lt;/span&gt;&lt;/span&gt; &lt;!--[endif]--&gt;Rheumatoid scleroderma, etc. &lt;strong&gt;&lt;em&gt;8:14&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoListParagraphCxSpMiddle" style= "text-indent: -.25in; line-height: 106%; mso-list: l0 level1 lfo1;"&gt; &lt;!-- [if !supportLists]--&gt;&lt;span style= "font-family: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol; mso-bidi-font-style: italic;"&gt;&lt;span style="mso-list: Ignore;"&gt;·&lt;span style="font: 7.0pt 'Times New Roman';"&gt;      &lt;/span&gt;&lt;/span&gt;&lt;/span&gt; &lt;!--[endif]--&gt;Cardiff pneumoconiosis medical panel &lt;strong&gt;&lt;em&gt;9:49&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoListParagraphCxSpMiddle" style= "text-indent: -.25in; line-height: 106%; mso-list: l0 level1 lfo1;"&gt; &lt;!-- [if !supportLists]--&gt;&lt;span style= "font-family: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol; mso-bidi-font-style: italic;"&gt;&lt;span style="mso-list: Ignore;"&gt;·&lt;span style="font: 7.0pt 'Times New Roman';"&gt;      &lt;/span&gt;&lt;/span&gt;&lt;/span&gt; &lt;!--[endif]--&gt;Databases &lt;strong&gt;&lt;em&gt;12:51&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoListParagraphCxSpMiddle" style= "text-indent: -.25in; line-height: 106%; mso-list: l0 level1 lfo1;"&gt; &lt;!-- [if !supportLists]--&gt;&lt;span style= "font-family: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol; mso-bidi-font-style: italic;"&gt;&lt;span style="mso-list: Ignore;"&gt;·&lt;span style="font: 7.0pt 'Times New Roman';"&gt;      &lt;/span&gt;&lt;/span&gt;&lt;/span&gt; &lt;!--[endif]--&gt;Silica exposure and the development of serologies &lt;strong&gt;&lt;em&gt;15:02&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoListParagraphCxSpMiddle" style= "text-indent: -.25in; line-height: 106%; mso-list: l0 level1 lfo1;"&gt; &lt;!-- [if !supportLists]--&gt;&lt;span style= "font-family: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol; mso-bidi-font-style: italic;"&gt;&lt;span style="mso-list: Ignore;"&gt;·&lt;span style="font: 7.0pt 'Times New Roman';"&gt;      &lt;/span&gt;&lt;/span&gt;&lt;/span&gt; &lt;!--[endif]--&gt;What would happen if you injected silica into the veins? &lt;strong&gt;&lt;em&gt;16:51&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoListParagraphCxSpMiddle" style= "text-indent: -.25in; line-height: 106%; mso-list: l0 level1 lfo1;"&gt; &lt;!-- [if !supportLists]--&gt;&lt;span style= "font-family: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol; mso-bidi-font-style: italic;"&gt;&lt;span style="mso-list: Ignore;"&gt;·&lt;span style="font: 7.0pt 'Times New Roman';"&gt;      &lt;/span&gt;&lt;/span&gt;&lt;/span&gt; &lt;!--[endif]--&gt;Anca vasculitis &lt;strong&gt;&lt;em&gt;18:33&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoListParagraphCxSpLast" style= "text-indent: -.25in; line-height: 106%; mso-list: l0 level1 lfo1;"&gt; &lt;!-- [if !supportLists]--&gt;&lt;span style= "font-family: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol; mso-bidi-font-style: italic;"&gt;&lt;span style="mso-list: Ignore;"&gt;·&lt;span style="font: 7.0pt 'Times New Roman';"&gt;      &lt;/span&gt;&lt;/span&gt;&lt;/span&gt; &lt;!--[endif]--&gt;Thanks for listening &lt;strong&gt;&lt;em&gt;23:23&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoNormal"&gt;&lt;strong&gt;Disclosures:&lt;/strong&gt; Brown reports no relevant financial disclosures.&lt;/p&gt; &lt;p class="MsoNormal"&gt;We’d love to hear from you! Send your comments/questions to Dr. Brown at &lt;a href= "mailto:rheuminationspodcast@healio.com"&gt;rheuminationspodcast@healio.com&lt;/a&gt;. Follow us on Twitter &lt;a href= "https://twitter.com/HRheuminations"&gt;@HRheuminations&lt;/a&gt; &lt;a href= "https://twitter.com/AdamJBrownMD"&gt;@AdamJBrownMD&lt;/a&gt; &lt;a href= "https://twitter.com/HealioRheum"&gt;@HealioRheum&lt;/a&gt;.&lt;/p&gt; &lt;p class="MsoNormal"&gt;&lt;strong&gt;References:&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoNormal"&gt;&lt;a href= "https://www.amjmed.com/article/S0002-9343(15)00425-8/fulltext"&gt;Blanc PD, et al. &lt;em&gt;Am J Med&lt;/em&gt;. 2015;doi:10.1016/j.amjmed.2015.05.001.&lt;/a&gt;&lt;/p&gt; &lt;p class="MsoNormal"&gt;&lt;a href= "https://academic.oup.com/ije/article/50/4/1213/6104043?login=false"&gt; Boudigaard SH, et al. &lt;em&gt;Int J Epidemiol&lt;/em&gt;. 2021;doi:10.1093/ije/dyaa287.&lt;/a&gt;&lt;/p&gt; &lt;p class="MsoNormal"&gt;&lt;a href= "https://journals.sagepub.com/doi/10.1177/096120339600500112"&gt;Conrad K, et al. &lt;em&gt;Lupus&lt;/em&gt;. 1996;doi:10.1177/096120339600500112.&lt;/a&gt;&lt;/p&gt; &lt;p class="MsoNormal"&gt;&lt;a href= "https://onlinelibrary.wiley.com/doi/10.1111/all.14202"&gt;Hoy RF, et al. &lt;em&gt;Allergy&lt;/em&gt;. 2020;doi:10.111/all.14202.&lt;/a&gt;&lt;/p&gt; &lt;p class="MsoNormal"&gt;&lt;a href= "https://www.bmj.com/content/294/6578/997"&gt;Klockars M, et al. &lt;em&gt;Br Med J (Clin Res Ed)&lt;/em&gt;. 1987;doi:10.1136/bmj.294.6578.997.&lt;/a&gt;&lt;/p&gt; &lt;p class="MsoNormal"&gt;&lt;a href= "https://ehp.niehs.nih.gov/doi/10.1289/ehp.99107s5793"&gt;Park CG, et al. &lt;em&gt;Environ Health Perspect&lt;/em&gt;. 1999;doi:10.1289/ehp.99107s5793.&lt;/a&gt;&lt;/p&gt; &lt;p class="MsoNormal"&gt;&lt;a href= "https://www.frontiersin.org/articles/10.3389/fimmu.2016.00097/full"&gt; Pollard KM. &lt;em&gt;Front Immunol&lt;/em&gt;. 2016;doi:10.3389/fimmu.2016.00097.&lt;/a&gt; &lt;span style= "mso-spacerun: yes;"&gt; &lt;/span&gt;&lt;/p&gt;</description>

Healio Rheuminations

Adam J. Brown, MD

It's in the Air: Silica exposure and the risk of autoimmunity, Part 4

NOV 15, 202323 MIN
Healio Rheuminations

It's in the Air: Silica exposure and the risk of autoimmunity, Part 4

NOV 15, 202323 MIN

Description

What is silica? How does it impact your risk of developing autoimmunity if you inhale it, inject it or even snort it up your nose? Listen and find out!

·       Intro 0:12

·       In the previous episodes 0:28

·       The Ajax incident of 1979 1:15

·       Silica and its association with autoimmune disease 4:11

·       The history of silica and the health risks 5:21

·       Rheumatoid scleroderma, etc. 8:14

·       Cardiff pneumoconiosis medical panel 9:49

·       Databases 12:51

·       Silica exposure and the development of serologies 15:02

·       What would happen if you injected silica into the veins? 16:51

·       Anca vasculitis 18:33

·       Thanks for listening 23:23

Disclosures: Brown reports no relevant financial disclosures.

We’d love to hear from you! Send your comments/questions to Dr. Brown at [email protected]. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.

References:

Blanc PD, et al. Am J Med. 2015;doi:10.1016/j.amjmed.2015.05.001.

Boudigaard SH, et al. Int J Epidemiol. 2021;doi:10.1093/ije/dyaa287.

Conrad K, et al. Lupus. 1996;doi:10.1177/096120339600500112.

Hoy RF, et al. Allergy. 2020;doi:10.111/all.14202.

Klockars M, et al. Br Med J (Clin Res Ed). 1987;doi:10.1136/bmj.294.6578.997.

Park CG, et al. Environ Health Perspect. 1999;doi:10.1289/ehp.99107s5793.

Pollard KM. Front Immunol. 2016;doi:10.3389/fimmu.2016.00097.