<description>&lt;p class="MsoNormal"&gt;&lt;span style= "mso-fareast-font-family: 'Times New Roman'; color: black;"&gt;This episode digs into the pathophysiology of urticaria vasculitis from anti-C1q to the story of bradykinin.&lt;/span&gt;&lt;/p&gt; &lt;p class="MsoListParagraphCxSpFirst" style= "text-indent: -.25in; line-height: 106%; mso-list: l0 level1 lfo1;"&gt; &lt;!-- [if !supportLists]--&gt;&lt;span style= "font-family: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol;"&gt;&lt;span style="mso-list: Ignore;"&gt;·&lt;span style="font: 7.0pt 'Times New Roman';"&gt;      &lt;/span&gt;&lt;/span&gt;&lt;/span&gt; &lt;!--[endif]--&gt;Intro &lt;strong style= "mso-bidi-font-weight: normal;"&gt;&lt;em style= "mso-bidi-font-style: normal;"&gt;0:11&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoListParagraphCxSpMiddle" style= "text-indent: -.25in; line-height: 106%; mso-list: l0 level1 lfo1;"&gt; &lt;!-- [if !supportLists]--&gt;&lt;span style= "font-family: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol; mso-bidi-font-style: italic;"&gt;&lt;span style="mso-list: Ignore;"&gt;·&lt;span style="font: 7.0pt 'Times New Roman';"&gt;      &lt;/span&gt;&lt;/span&gt;&lt;/span&gt; &lt;!--[endif]--&gt;In this episode &lt;strong&gt;&lt;em&gt;0:22&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoListParagraphCxSpMiddle" style= "text-indent: -.25in; line-height: 106%; mso-list: l0 level1 lfo1;"&gt; &lt;!-- [if !supportLists]--&gt;&lt;span style= "font-family: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol; mso-bidi-font-style: italic;"&gt;&lt;span style="mso-list: Ignore;"&gt;·&lt;span style="font: 7.0pt 'Times New Roman';"&gt;      &lt;/span&gt;&lt;/span&gt;&lt;/span&gt; &lt;!--[endif]--&gt;Review of episode 83 &lt;strong&gt;&lt;em&gt;1:23&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoListParagraphCxSpMiddle" style= "text-indent: -.25in; line-height: 106%; mso-list: l0 level1 lfo1;"&gt; &lt;!-- [if !supportLists]--&gt;&lt;span style= "font-family: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol; mso-bidi-font-style: italic;"&gt;&lt;span style="mso-list: Ignore;"&gt;·&lt;span style="font: 7.0pt 'Times New Roman';"&gt;      &lt;/span&gt;&lt;/span&gt;&lt;/span&gt; &lt;!--[endif]--&gt;Listen to previous episode, &lt;a href= "https://www.healio.com/news/rheumatology/podcasts/rheuminations/episode-46"&gt; The Complement System for Dunces&lt;/a&gt; &lt;strong&gt;&lt;em&gt;4:09&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoListParagraphCxSpMiddle" style= "text-indent: -.25in; line-height: 106%; mso-list: l0 level1 lfo1;"&gt; &lt;!-- [if !supportLists]--&gt;&lt;span style= "font-family: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol; mso-bidi-font-style: italic;"&gt;&lt;span style="mso-list: Ignore;"&gt;·&lt;span style="font: 7.0pt 'Times New Roman';"&gt;      &lt;/span&gt;&lt;/span&gt;&lt;/span&gt; &lt;!--[endif]--&gt;Anti-C1q antibodies &lt;strong&gt;&lt;em&gt;6:26&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoListParagraphCxSpMiddle" style= "text-indent: -.25in; line-height: 106%; mso-list: l0 level1 lfo1;"&gt; &lt;!-- [if !supportLists]--&gt;&lt;span style= "font-family: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol; mso-bidi-font-style: italic;"&gt;&lt;span style="mso-list: Ignore;"&gt;·&lt;span style="font: 7.0pt 'Times New Roman';"&gt;      &lt;/span&gt;&lt;/span&gt;&lt;/span&gt; &lt;!--[endif]--&gt;Lupus, anti-C1q and lupus nephritis &lt;strong&gt;&lt;em&gt;9:33&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoListParagraphCxSpMiddle" style= "text-indent: -.25in; line-height: 106%; mso-list: l0 level1 lfo1;"&gt; &lt;!-- [if !supportLists]--&gt;&lt;span style= "font-family: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol;"&gt;&lt;span style="mso-list: Ignore;"&gt;·&lt;span style="font: 7.0pt 'Times New Roman';"&gt;      &lt;/span&gt;&lt;/span&gt;&lt;/span&gt; &lt;!--[endif]--&gt;What happens when you inject anti-C1q in a mouse? &lt;strong&gt;&lt;em&gt;12:56&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoListParagraphCxSpMiddle" style= "text-indent: -.25in; line-height: 106%; mso-list: l0 level1 lfo1;"&gt; &lt;!-- [if !supportLists]--&gt;&lt;span style= "font-family: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol; mso-bidi-font-style: italic;"&gt;&lt;span style="mso-list: Ignore;"&gt;·&lt;span style="font: 7.0pt 'Times New Roman';"&gt;      &lt;/span&gt;&lt;/span&gt;&lt;/span&gt; &lt;!--[endif]--&gt;The allergy component: anti-C1q, urticaria and angioedema &lt;strong&gt;&lt;em&gt;17:36&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoListParagraphCxSpMiddle" style= "text-indent: -.25in; line-height: 106%; mso-list: l0 level1 lfo1;"&gt; &lt;!-- [if !supportLists]--&gt;&lt;span style= "font-family: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol; mso-bidi-font-style: italic;"&gt;&lt;span style="mso-list: Ignore;"&gt;·&lt;span style="font: 7.0pt 'Times New Roman';"&gt;      &lt;/span&gt;&lt;/span&gt;&lt;/span&gt; &lt;!--[endif]--&gt;Bradykinin-mediated angioedema and C1q deficiency &lt;strong&gt;&lt;em&gt;24:20&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoListParagraphCxSpMiddle" style= "text-indent: -.25in; line-height: 106%; mso-list: l0 level1 lfo1;"&gt; &lt;!-- [if !supportLists]--&gt;&lt;span style= "font-family: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol; mso-bidi-font-style: italic;"&gt;&lt;span style="mso-list: Ignore;"&gt;·&lt;span style="font: 7.0pt 'Times New Roman';"&gt;      &lt;/span&gt;&lt;/span&gt;&lt;/span&gt; &lt;!--[endif]--&gt;What is the kinin kallikrein system? &lt;strong&gt;&lt;em&gt;26:21&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoListParagraphCxSpMiddle" style= "text-indent: -.25in; line-height: 106%; mso-list: l0 level1 lfo1;"&gt; &lt;!-- [if !supportLists]--&gt;&lt;span style= "font-family: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol; mso-bidi-font-style: italic;"&gt;&lt;span style="mso-list: Ignore;"&gt;·&lt;span style="font: 7.0pt 'Times New Roman';"&gt;      &lt;/span&gt;&lt;/span&gt;&lt;/span&gt; &lt;!--[endif]--&gt;French researchers in 1909: human urine injected in dogs &lt;strong&gt;&lt;em&gt;27:30&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoListParagraphCxSpMiddle" style= "text-indent: -.25in; line-height: 106%; mso-list: l0 level1 lfo1;"&gt; &lt;!-- [if !supportLists]--&gt;&lt;span style= "font-family: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol; mso-bidi-font-style: italic;"&gt;&lt;span style="mso-list: Ignore;"&gt;·&lt;span style="font: 7.0pt 'Times New Roman';"&gt;      &lt;/span&gt;&lt;/span&gt;&lt;/span&gt; &lt;!--[endif]--&gt;How is this relevant to urticarial vasculitis? &lt;strong&gt;&lt;em&gt;31:08&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoListParagraphCxSpMiddle" style= "text-indent: -.25in; line-height: 106%; mso-list: l0 level1 lfo1;"&gt; &lt;!-- [if !supportLists]--&gt;&lt;span style= "font-family: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol; mso-bidi-font-style: italic;"&gt;&lt;span style="mso-list: Ignore;"&gt;·&lt;span style="font: 7.0pt 'Times New Roman';"&gt;      &lt;/span&gt;&lt;/span&gt;&lt;/span&gt; &lt;!--[endif]--&gt;SERPING1 gene mutation &lt;strong&gt;&lt;em&gt;31:23&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoListParagraphCxSpMiddle" style= "text-indent: -.25in; line-height: 106%; mso-list: l0 level1 lfo1;"&gt; &lt;!-- [if !supportLists]--&gt;&lt;span style= "font-family: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol;"&gt;&lt;span style="mso-list: Ignore;"&gt;·&lt;span style="font: 7.0pt 'Times New Roman';"&gt;      &lt;/span&gt;&lt;/span&gt;&lt;/span&gt; &lt;!--[endif]--&gt;Summary &lt;strong&gt;&lt;em&gt;32:06&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoListParagraphCxSpMiddle" style= "text-indent: -.25in; line-height: 106%; mso-list: l0 level1 lfo1;"&gt; &lt;!-- [if !supportLists]--&gt;&lt;span style= "font-family: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol; mso-bidi-font-style: italic;"&gt;&lt;span style="mso-list: Ignore;"&gt;·&lt;span style="font: 7.0pt 'Times New Roman';"&gt;      &lt;/span&gt;&lt;/span&gt;&lt;/span&gt; &lt;!--[endif]--&gt;COPD association with urticarial vasculitis &lt;strong&gt;&lt;em&gt;33:51&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoListParagraphCxSpMiddle" style= "text-indent: -.25in; line-height: 106%; mso-list: l0 level1 lfo1;"&gt; &lt;!-- [if !supportLists]--&gt;&lt;span style= "font-family: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol; mso-bidi-font-style: italic;"&gt;&lt;span style="mso-list: Ignore;"&gt;·&lt;span style="font: 7.0pt 'Times New Roman';"&gt;      &lt;/span&gt;&lt;/span&gt;&lt;/span&gt; &lt;!--[endif]--&gt;Coming up in episode 85 &lt;strong&gt;&lt;em&gt;35:28&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoListParagraphCxSpLast" style= "text-indent: -.25in; line-height: 106%; mso-list: l0 level1 lfo1;"&gt; &lt;!-- [if !supportLists]--&gt;&lt;span style= "font-family: Symbol; mso-fareast-font-family: Symbol; mso-bidi-font-family: Symbol; mso-bidi-font-style: italic;"&gt;&lt;span style="mso-list: Ignore;"&gt;·&lt;span style="font: 7.0pt 'Times New Roman';"&gt;      &lt;/span&gt;&lt;/span&gt;&lt;/span&gt; &lt;!--[endif]--&gt;Thanks for listening &lt;strong&gt;&lt;em&gt;35:45&lt;/em&gt;&lt;/strong&gt;&lt;/p&gt; &lt;p class="MsoNormal"&gt;&lt;strong&gt;Disclosures:&lt;/strong&gt; Brown reports no relevant financial disclosures.&lt;/p&gt; &lt;p class="MsoNormal"&gt;We’d love to hear from you! Send your comments/questions to Dr. Brown at &lt;a href= "mailto:rheuminationspodcast@healio.com"&gt;rheuminationspodcast@healio.com&lt;/a&gt;. Follow us on Twitter &lt;a href= "https://twitter.com/HRheuminations"&gt;@HRheuminations&lt;/a&gt; &lt;a href= "https://twitter.com/AdamJBrownMD"&gt;@AdamJBrownMD&lt;/a&gt; &lt;a href= "https://twitter.com/HealioRheum"&gt;@HealioRheum&lt;/a&gt;.&lt;/p&gt; &lt;p class="MsoNormal"&gt;&lt;strong&gt;References:&lt;/strong&gt;&lt;/p&gt; &lt;p class="elementtoproof1" style="margin-bottom: 12.0pt;"&gt;&lt;a href= "https://www.jaci-inpractice.org/article/S2213-2198(21)01289-7/fulltext"&gt; Busse P, et al. &lt;em&gt;J Allergy Clin Immunol Pract.&lt;/em&gt; 2022;doi:10.1016/j.jaip.2021.11.011.&lt;/a&gt;&lt;/p&gt; &lt;p class="elementtoproof1" style="margin-bottom: 12.0pt;"&gt;&lt;a href= "https://www.jaci-inpractice.org/article/S2213-2198(18)30328-3/abstract"&gt; Davis MDP, et al. &lt;em&gt;J Allergy Clin Immunol Pract&lt;/em&gt;. 2018;doi:10.1016/j.jaip.2018.05.006.&lt;/a&gt;&lt;/p&gt; &lt;p class="elementtoproof1" style="margin-bottom: 12.0pt;"&gt;&lt;a href= "https://www.annallergy.org/article/S1081-1206(23)00421-0/abstract"&gt; Dorn JM, et al. &lt;em&gt;Ann Allergy Asthma Immunol.&lt;/em&gt; 2023;doi:10.1016/j.anai.2023.06.014.&lt;/a&gt;&lt;/p&gt; &lt;p class="elementtoproof1" style="margin-bottom: 12.0pt;"&gt;&lt;a href= "https://www.jacionline.org/article/S0091-6749(22)00225-1/fulltext"&gt; Marzano AV, et al. &lt;em&gt;J Allergy Clin Immunol.&lt;/em&gt; 2022;doi:10.1016/j.jaci.2022.02.007.&lt;/a&gt;&lt;/p&gt; &lt;p class="elementtoproof1" style="margin-bottom: 12.0pt;"&gt;&lt;a href= "https://www.sciencedirect.com/science/article/abs/pii/S0090122983710664?via%3Dihub"&gt; Siegert CE, et al. &lt;em&gt;Clin Immunol Immunopathol.&lt;/em&gt; 1993;doi:10.1006/clin.1993.1066.&lt;/a&gt;&lt;/p&gt; &lt;p class="elementtoproof1" style="margin-bottom: 12.0pt;"&gt;&lt;a href= "https://journals.sagepub.com/doi/10.1177/0961203316645205"&gt;Stojan G, et al. &lt;em&gt;Lupus.&lt;/em&gt; 2016;doi:10.1177/0961203316645205.&lt;/a&gt;&lt;/p&gt; &lt;p class="elementtoproof1" style="margin-bottom: 12.0pt;"&gt;&lt;a href= "https://link.springer.com/article/10.1385/CRIAI:23:2:201"&gt;Venzor J, et al. &lt;em&gt;Clin Rev Allergy Immunol&lt;/em&gt;. 2002;doi:10.1385/CRIAI:23:2:201.&lt;/a&gt;&lt;/p&gt; &lt;p class="elementtoproof1" style="margin-bottom: 12.0pt;"&gt;&lt;a href= "https://journals.lww.com/md-journal/citation/1995/01000/hypocomplementemic_urticarial_vasculitis_syndrome_.3.aspx"&gt; Wisnieski JJ, et al. &lt;em&gt;Medicine.&lt;/em&gt; 1995;doi:10.1097/00005792-199501000-00003.&lt;/a&gt;&lt;/p&gt;</description>

Healio Rheuminations

Adam J. Brown, MD

Urticarial Vasculitis, Part 2: Walking the Balance Beam of Allergy and Rheumatology

APR 18, 202435 MIN
Healio Rheuminations

Urticarial Vasculitis, Part 2: Walking the Balance Beam of Allergy and Rheumatology

APR 18, 202435 MIN

Description

This episode digs into the pathophysiology of urticaria vasculitis from anti-C1q to the story of bradykinin.

·       Intro 0:11

·       In this episode 0:22

·       Review of episode 83 1:23

·       Listen to previous episode, The Complement System for Dunces 4:09

·       Anti-C1q antibodies 6:26

·       Lupus, anti-C1q and lupus nephritis 9:33

·       What happens when you inject anti-C1q in a mouse? 12:56

·       The allergy component: anti-C1q, urticaria and angioedema 17:36

·       Bradykinin-mediated angioedema and C1q deficiency 24:20

·       What is the kinin kallikrein system? 26:21

·       French researchers in 1909: human urine injected in dogs 27:30

·       How is this relevant to urticarial vasculitis? 31:08

·       SERPING1 gene mutation 31:23

·       Summary 32:06

·       COPD association with urticarial vasculitis 33:51

·       Coming up in episode 85 35:28

·       Thanks for listening 35:45

Disclosures: Brown reports no relevant financial disclosures.

We’d love to hear from you! Send your comments/questions to Dr. Brown at [email protected]. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.

References:

Busse P, et al. J Allergy Clin Immunol Pract. 2022;doi:10.1016/j.jaip.2021.11.011.

Davis MDP, et al. J Allergy Clin Immunol Pract. 2018;doi:10.1016/j.jaip.2018.05.006.

Dorn JM, et al. Ann Allergy Asthma Immunol. 2023;doi:10.1016/j.anai.2023.06.014.

Marzano AV, et al. J Allergy Clin Immunol. 2022;doi:10.1016/j.jaci.2022.02.007.

Siegert CE, et al. Clin Immunol Immunopathol. 1993;doi:10.1006/clin.1993.1066.

Stojan G, et al. Lupus. 2016;doi:10.1177/0961203316645205.

Venzor J, et al. Clin Rev Allergy Immunol. 2002;doi:10.1385/CRIAI:23:2:201.

Wisnieski JJ, et al. Medicine. 1995;doi:10.1097/00005792-199501000-00003.