<p>This week, Gary, Kate, Mark and Henry discuss the optimal duration of anticoagulation after a provoked DVT, using low doses of mirtazapine or amitriptyline in adults with insomnia, whether a lower dose of semaglutide is still effective for weight loss, and adding aspirin for patients with coronary heart disease, a stent and who are also on a DOAC for another indication.</p><p>Links:</p><p>NICE Barrett Esophagus guideline: <a href="https://pubmed.ncbi.nlm.nih.gov/38553042/"><u>https://pubmed.ncbi.nlm.nih.gov/38553042/</u></a> </p><p>Essential Evidence Plus: <a href="http://www.essentialevidenceplus.com"><u>www.essentialevidenceplus.com</u></a></p><p>Duration of anticoagulation: <a href="https://pubmed.ncbi.nlm.nih.gov/40888734/"><u>https://pubmed.ncbi.nlm.nih.gov/40888734/</u></a> </p><p>Mirtazapine or amitriptyline for insomnia: <a href="https://pubmed.ncbi.nlm.nih.gov/39814428/"><u>ttps://pubmed.ncbi.nlm.nih.gov/39814428/</u></a> </p><p>Lower dose semaglutide for obesity: <a href="https://pubmed.ncbi.nlm.nih.gov/40934115/"><u>https://pubmed.ncbi.nlm.nih.gov/40934115/</u></a> </p><p>Adding aspirin: <a href="https://pubmed.ncbi.nlm.nih.gov/40888725/"><em>N Engl J Med . 2025 Oct 23;393(16):1578-1588</em></a><a href="https://pubmed.ncbi.nlm.nih.gov/40888725/"><u>https://pubmed.ncbi.nlm.nih.gov/40888725/</u></a> </p><p><br></p>