<p>In this third collaboration between SIDP’s Breakpoints and ESCMID’s Communicable podcasts, hosts Erin McCreary and Angela Huttner invite two veteran authors of guidelines and guidances, Pranita Tamma (Philadelphia, USA) and Benedikt Huttner (WHO, Geneva, Switzerland) [1-3]. Together, they deconstruct the complex landscape of developing and implementing guidelines into digestible components: they discuss why different organizations develop guidelines and what need they hope to fulfil, the framework including the GRADE methodology under which guidelines are written, and major barriers in the uptake of guidelines. The conversation also details the distinction between guideline and guidance as well as the art and science behind formulating recommendations or suggestions, with a few anecdotal cases sprinkled in from the panel.</p> <p>References</p> <p>1. WHO handbook for guideline development, 2nd Edition, <a href="https://www.who.int/publications/i/item/9789241548960" rel="nofollow">https://www.who.int/publications/i/item/9789241548960</a></p> <p>2. The WHO AWaRe (Access, Watch, Reserve) antibiotic book <a href="https://www.who.int/publications/i/item/9789240062382" rel="nofollow">https://www.who.int/publications/i/item/9789240062382</a> </p> <p>3. IDSA 2024 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections, <a href="https://www.idsociety.org/practice-guideline/amr-guidance/" rel="nofollow">https://www.idsociety.org/practice-guideline/amr-guidance/</a></p> <p>Learn more about the Society of Infectious Diseases Pharmacists: <a href="https://protect2.fireeye.com/v1/url?k=4063f96c-1ff8c1be-4063b7ad-867b1e11f55a-4ebd02e8eaa2fcc2\&amp;q=1\&amp;e=caf63b63-0143-4fa9-a81b-8d3031af3116\&amp;u=https%3A%2F%2Fsidp.org%2FAbout" rel="nofollow">https://sidp.org/About</a></p> <p>Twitter: @SIDPharm (<a href="https://twitter.com/SIDPharm" rel="nofollow">https://twitter.com/SIDPharm</a>)</p> <p>Instagram: @SIDPharm (<a href="https://www.instagram.com/sidpharm/" rel="nofollow">https://www.instagram.com/sidpharm/</a>)</p> <p>Facebook: <a 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