The 2023 conference was unified by the theme of innovation. Between 2023 and 2030, there will be at least ten new and expensive therapies approved every year. But in Australia and many other nations, these won't necessarily be funded. Furthermore, there will be off-licence requests to use these innovations and other emerging therapies, along with new devices and surgical developments. How should clinicians, hospitals and health services approach this issue? How should bioethics be positioned to support these requests and the introduction of new and emerging treatments? This is a recording of the opening plenary of the 2023 conference. Speaker: Assistant Professor Bryanna Moore, Department of Bioethics and Health Humanities at the University of Texas Medical Branch and chair, American Society for Bioethics and Humanities, Paediatric Ethics Affinity Group. Host: Professor John Massie, Children's Bioethics Centre, The Royal Children's Hospital Melbourne.