Trial of the Week: ESETTSpecial Guest: Ashley McCormick, PharmD, BCPS, BCCCP  Ashley McCormick joins to discuss the April Trial of the Week “Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus” the ESETT study, published in NEJM in 2019. We set the scene by reviewing ASM PK/PD properties and discussing if there was a standard of care first-line treatment. Then we do a deep dive into the ESETT trial of the week. Did the 75kg dose cap influence results? How appropriate was the BZD dosing? How does this % of seizure cessation compare to other studies? Where did this dosing scheme come from? Trial fun facts, medication safety considerations, and much, much more. Reference list: <a href="https://pharmacytodose.files.wordpress.com/2024/04/esett-trial-of-the-week-references.pdf">https://pharmacytodose.files.wordpress.com/2024/04/esett-trial-of-the-week-references.pdf</a> PharmacyToDose.Com@PharmacyToDose<a href="mailto:PharmacyToDose@Gmail.com">PharmacyToDose@Gmail.com</a> Learn more about your ad choices. Visit <a href="https://megaphone.fm/adchoices">megaphone.fm/adchoices</a>

<description>Trial of the Week: ESETT
Special Guest: Ashley McCormick, PharmD, BCPS, BCCCP 
 
Ashley McCormick joins to discuss the April Trial of the Week “Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus” the ESETT study, published in NEJM in 2019. 
We set the scene by reviewing ASM PK/PD properties and discussing if there was a standard of care first-line treatment. Then we do a deep dive into the ESETT trial of the week. Did the 75kg dose cap influence results? How appropriate was the BZD dosing? How does this % of seizure cessation compare to other studies? Where did this dosing scheme come from? Trial fun facts, medication safety considerations, and much, much more. 
Reference list: https://pharmacytodose.files.wordpress.com/2024/04/esett-trial-of-the-week-references.pdf
 
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Ashley McCormick highlights the ESETT study in this April Trial of the Week. 

Trial of the Week: ESETT
Special Guest: Ashley McCormick, PharmD, BCPS, BCCCP 
 
Ashley McCormick joins to discuss the April Trial of the Week “Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus” the ESETT study, published in NEJM in 2019. 
We set the scene by reviewing ASM PK/PD properties and discussing if there was a standard of care first-line treatment. Then we do a deep dive into the ESETT trial of the week. Did the 75kg dose cap influence results? How appropriate was the BZD dosing? How does this % of seizure cessation compare to other studies? Where did this dosing scheme come from? Trial fun facts, medication safety considerations, and much, much more. 
Reference list: https://pharmacytodose.files.wordpress.com/2024/04/esett-trial-of-the-week-references.pdf
 
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Trial of the Week: ESETT

Thrombolytic Dosing in PE: Versus SeriesSpecial Guest: Lauren Igneri, PharmD, BCPS, BCCCP, FCCM 05:20 – High-risk PE23:00 – Intermediate-risk37:10 – Cardiac arrest52:30 – Closing arguments57:15 – Bonus: TNK v. tPA Reference List: <a href="https://pharmacytodose.files.wordpress.com/2024/04/thrombolytic-dosing-in-pe-references.pdf">https://pharmacytodose.files.wordpress.com/2024/04/thrombolytic-dosing-in-pe-references.pdf</a> PharmacyToDose.Com@PharmacyToDose<a href="mailto:PharmacyToDose@Gmail.com">PharmacyToDose@Gmail.com</a> Learn more about your ad choices. Visit <a href="https://megaphone.fm/adchoices">megaphone.fm/adchoices</a>

<description>Thrombolytic Dosing in PE: Versus Series
Special Guest: Lauren Igneri, PharmD, BCPS, BCCCP, FCCM
 
05:20 – High-risk PE
23:00 – Intermediate-risk
37:10 – Cardiac arrest
52:30 – Closing arguments
57:15 – Bonus: TNK v. tPA
 
Reference List: https://pharmacytodose.files.wordpress.com/2024/04/thrombolytic-dosing-in-pe-references.pdf
 
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Lauren Igneri and I debate “Thrombolytic Dosing in PE,” as part of the Versus series.

Thrombolytic Dosing in PE: Versus Series
Special Guest: Lauren Igneri, PharmD, BCPS, BCCCP, FCCM
 
05:20 – High-risk PE
23:00 – Intermediate-risk
37:10 – Cardiac arrest
52:30 – Closing arguments
57:15 – Bonus: TNK v. tPA
 
Reference List: https://pharmacytodose.files.wordpress.com/2024/04/thrombolytic-dosing-in-pe-references.pdf
 
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Thrombolytic Dosing in PE: Versus Series

Trial of the Week: SEPSISPAMSpecial Guest: Katherine Spezzano, PharmD, MBA, BCCCP @KatSpazPharmD Katherine Spezzano joins to discuss the April Trial of the Week “High versus Low Blood-Pressure Target in Patients with Septic Shock” the SEPSISPAM study, published in NEJM in 2014. We set the scene by reviewing the concept of autoregulation, guideline recommendations, and pre-SEPSISPAM research assessing BP goals in sepsis. Then we do a deep dive into the SEPSISPAM trial of the week. Would we see these same results with other vasopressors? Did each group meet their BP goal range? How do we balance AKI prevention and longer ICU LOS? What do our guidelines recommend now? Trial fun facts, alternate trial acronym ideas, and much more!  Reference list: <a href="https://pharmacytodose.files.wordpress.com/2024/04/sepsispam-trial-of-the-week-references.pdf">https://pharmacytodose.files.wordpress.com/2024/04/sepsispam-trial-of-the-week-references.pdf</a> PharmacyToDose.Com@PharmacyToDose<a href="mailto:PharmacyToDose@Gmail.com">PharmacyToDose@Gmail.com</a> Learn more about your ad choices. Visit <a href="https://megaphone.fm/adchoices">megaphone.fm/adchoices</a>

<description>Trial of the Week: SEPSISPAM
Special Guest: Katherine Spezzano, PharmD, MBA, BCCCP @KatSpazPharmD
 
Katherine Spezzano joins to discuss the April Trial of the Week “High versus Low Blood-Pressure Target in Patients with Septic Shock” the SEPSISPAM study, published in NEJM in 2014. 
We set the scene by reviewing the concept of autoregulation, guideline recommendations, and pre-SEPSISPAM research assessing BP goals in sepsis. Then we do a deep dive into the SEPSISPAM trial of the week. Would we see these same results with other vasopressors? Did each group meet their BP goal range? How do we balance AKI prevention and longer ICU LOS? What do our guidelines recommend now? Trial fun facts, alternate trial acronym ideas, and much more! 
 
Reference list: https://pharmacytodose.files.wordpress.com/2024/04/sepsispam-trial-of-the-week-references.pdf
 
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Katherine Spezzano highlights the SEPSISPAM study in this April Trial of the Week.

Trial of the Week: SEPSISPAM
Special Guest: Katherine Spezzano, PharmD, MBA, BCCCP @KatSpazPharmD
 
Katherine Spezzano joins to discuss the April Trial of the Week “High versus Low Blood-Pressure Target in Patients with Septic Shock” the SEPSISPAM study, published in NEJM in 2014. 
We set the scene by reviewing the concept of autoregulation, guideline recommendations, and pre-SEPSISPAM research assessing BP goals in sepsis. Then we do a deep dive into the SEPSISPAM trial of the week. Would we see these same results with other vasopressors? Did each group meet their BP goal range? How do we balance AKI prevention and longer ICU LOS? What do our guidelines recommend now? Trial fun facts, alternate trial acronym ideas, and much more! 
 
Reference list: https://pharmacytodose.files.wordpress.com/2024/04/sepsispam-trial-of-the-week-references.pdf
 
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Trial of the Week: SEPSISPAM

Glycemic Control in the Critically Ill: Part IISpecial Guests: Judi Jacobi, PharmD, FCCP, MCCM, BCCCP @JudiJacobiMichael Sirimaturos, PharmD, BCNSP, BCCCP, FCCM @MSirimaturos 04:10 – Becoming panel members11:50 – Guideline scope and PICO questions21:35 – 2012 v. 2024 guidelines28:05 – Effect of TGC-FAST30:40 – 2024 guideline deep-dive42:00 – Clinical decision support tools50:00 – Pediatric recommendations54:40 – Important future research topics66:05 – Guideline manuscript writing76:10 – Take-home points Reference List: <a href="https://pharmacytodose.files.wordpress.com/2024/04/glycemic-control-in-the-icu-part-ii-references.pdf">https://pharmacytodose.files.wordpress.com/2024/04/glycemic-control-in-the-icu-part-ii-references.pdf</a> PharmacyToDose.Com@PharmacyToDose<a href="mailto:PharmacyToDose@Gmail.com">PharmacyToDose@Gmail.com</a> Learn more about your ad choices. Visit <a href="https://megaphone.fm/adchoices">megaphone.fm/adchoices</a>

<description>Glycemic Control in the Critically Ill: Part II
Special Guests: Judi Jacobi, PharmD, FCCP, MCCM, BCCCP @JudiJacobi
Michael Sirimaturos, PharmD, BCNSP, BCCCP, FCCM @MSirimaturos
 
04:10 – Becoming panel members
11:50 – Guideline scope and PICO questions
21:35 – 2012 v. 2024 guidelines
28:05 – Effect of TGC-FAST
30:40 – 2024 guideline deep-dive
42:00 – Clinical decision support tools
50:00 – Pediatric recommendations
54:40 – Important future research topics
66:05 – Guideline manuscript writing
76:10 – Take-home points
 
Reference List: https://pharmacytodose.files.wordpress.com/2024/04/glycemic-control-in-the-icu-part-ii-references.pdf
 
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Judi Jacobi and Michael Sirimaturos, 2 Pharmacist panel members, review the 2024 SCCM Glycemic Control for Critically Ill Children and Adult Guidelines.  

Glycemic Control in the Critically Ill: Part II
Special Guests: Judi Jacobi, PharmD, FCCP, MCCM, BCCCP @JudiJacobi
Michael Sirimaturos, PharmD, BCNSP, BCCCP, FCCM @MSirimaturos
 
04:10 – Becoming panel members
11:50 – Guideline scope and PICO questions
21:35 – 2012 v. 2024 guidelines
28:05 – Effect of TGC-FAST
30:40 – 2024 guideline deep-dive
42:00 – Clinical decision support tools
50:00 – Pediatric recommendations
54:40 – Important future research topics
66:05 – Guideline manuscript writing
76:10 – Take-home points
 
Reference List: https://pharmacytodose.files.wordpress.com/2024/04/glycemic-control-in-the-icu-part-ii-references.pdf
 
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Glycemic Control in the Critically Ill: Part II

Literature Review SeriesNovember 2023Special Guests: Arjay Mendoza, PharmD, BCPS, AAHIVPBrock Townsend, PharmD @Townsend_PharmD 04:30 – Featured Articles35:25 – Cardiology48:05 – Precision-based medicine potpourri58:50 – Infectious Diseases69:10 – PharmD Reference List: <a href="https://pharmacytodose.files.wordpress.com/2024/04/november-lrs-2023-references.pdf">https://pharmacytodose.files.wordpress.com/2024/04/november-lrs-2023-references.pdf</a> PharmacyToDose.Com@PharmacyToDose<a href="mailto:PharmacyToDose@Gmail.com">PharmacyToDose@Gmail.com</a> Learn more about your ad choices. Visit <a href="https://megaphone.fm/adchoices">megaphone.fm/adchoices</a>

<description>Literature Review Series
November 2023
Special Guests: Arjay Mendoza, PharmD, BCPS, AAHIVP
Brock Townsend, PharmD @Townsend_PharmD
 
04:30 – Featured Articles
35:25 – Cardiology
48:05 – Precision-based medicine potpourri
58:50 – Infectious Diseases
69:10 – PharmD
 
Reference List: https://pharmacytodose.files.wordpress.com/2024/04/november-lrs-2023-references.pdf
 
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Brock Townsend and Arjay Mendoza join me to highlight some of the most pertinent articles and research published in November 2023. 

Literature Review Series
November 2023
Special Guests: Arjay Mendoza, PharmD, BCPS, AAHIVP
Brock Townsend, PharmD @Townsend_PharmD
 
04:30 – Featured Articles
35:25 – Cardiology
48:05 – Precision-based medicine potpourri
58:50 – Infectious Diseases
69:10 – PharmD
 
Reference List: https://pharmacytodose.files.wordpress.com/2024/04/november-lrs-2023-references.pdf
 
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November 2023 Literature Review Series

Pharmacy to Dose: The Critical Care Podcast discusses critical care and its pharmacotherapy in a fun and entertaining manner. Each episode features a special guest, a subject matter expert, talking with host Nick Peters.

Pharmacy to Dose: The Critical Care Podcast

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