<p>We kick this one off the way we always do — just talking. Paul&#39;s lupus is somehow in the best shape it&#39;s ever been despite a stretch of travel, stress, and general chaos, which honestly tracks.</p><p>He also got a new puppy named Charlie — a supposedly golden retriever who came out black, so there are some questions there. </p><p>I&#39;m reading my first fiction book in years (Dungeon Crawler Carl, it&#39;s actually great), heading to Vancouver to see my girlfriend, and planning a trip back to Connecticut to see family and let my mom dye my hair icy blonde. Normal stuff.</p><p>Then we get into the actual topic: GLP-1 medications. These things are everywhere right now — Ozempic, Wegovy, Mounjaro — and whether you&#39;re curious, currently using one, or coaching someone who is, this episode is worth your time. </p><p>Paul did his research (he called it extensive, I&#39;ll let you be the judge), and we break down what GLP-1s actually are, what glucagon-like peptide-1 does in the body, and why these medications work across multiple pathways — not just appetite suppression.</p><p>We talk about who actually benefits from GLP-1s, because it&#39;s not a blanket answer. We get into food noise — that constant mental chatter around food that a lot of people don&#39;t even realize they have until it goes quiet — and why that alone can be life-changing for certain people. </p><p>We also get real about the risks, the cost reality (most people are paying out of pocket), the side effects, and what the research actually shows versus what&#39;s being hyped on social media.</p><p>The part I think matters most: what happens when you come off them. This is where lifestyle, meal structure, and habits become non-negotiable. </p><p>The medication quiets hunger — it doesn&#39;t build the skills. That part is still on you. We talk through how we approach this with our own clients and what the off-ramp actually looks like when it&#39;s done right.</p><p><br></p><p>Paul&#39;s IG: @<strong>paulbuono</strong></p><p><br></p><p><strong>Chapters</strong></p><p><br></p><p>00:00 Introduction and Personal Updates</p><p>07:27 Understanding GOP-1 Medications</p><p>20:06 Who Can Benefit from GOP-1s?</p><p>22:27 The Importance of Lifestyle Changes with GOP-1s</p><p>26:25 Understanding Food Noise and Its Implications</p><p>27:28 Risks and Considerations of GLP-1 Medications</p><p>29:53 When to Consider Coming Off GLP-1 Medications</p><p>32:53 Side Effects and Management of GLP-1 Medications</p><p>36:42 Preparing for Life After GLP-1 Medications</p><p>42:24 Personal Updates and Future Plans</p><p><br></p><p>🔗<strong> Links &amp; Resources</strong><br></p><p>⭐<strong> Please leave a 5-star review wherever you listen to this podcast</strong><br></p><p>💪<strong> Apply for 1:1 Online Coaching</strong><br><a href="https://bodybyryan.com/coaching/"><strong>https://bodybyryan.com/coaching/</strong></a><strong></strong></p><p>🧮<strong> Use my FREE Calorie Calculator</strong><br><a href="https://bodybyryan.com/calculator/"><strong>https://bodybyryan.com/calculator/</strong></a><strong></strong></p><p>📸<strong> Follow me on Instagram</strong><br><a href="https://www.instagram.com/bodybyryanfitness/"><strong>https://www.instagram.com/bodybyryanfitness/</strong></a><strong></strong></p><p>🎵<strong> Follow me on TikTok</strong><br><a href="https://www.tiktok.com/@ryankassim?lang=eng"><strong>https://www.tiktok.com/@ryankassim?lang=eng</strong></a><strong></strong></p><p>▶️<strong> Subscribe on YouTube</strong><br><a href="https://www.youtube.com/ryankassimlifeisgood"><strong>https://www.youtube.com/ryankassimlifeisgood</strong></a></p>