Welcome back to the Hot Topics podcast from NB Medical with Dr Neal Tucker. In this episode, we look at three new pieces of research and have a special interview in conjunction with Prostate Cancer UK. First, do antidepressants have physiological side effects? How do they compare to each other, and how does this influence what we prescribe to whom?Second, exercise is a key treatment for knee osteoarthritis, but which type is best? What should we recommend to our patients?Third, how has PSA testing changed over the past two decades? Is there variation in testing in high-risk groups? Discussing this further, we are joined by Dr Bunmi Olajide, a GP with a special interest in cancer, and Kevin Howell, Black Health Equity Engagement manager for Prostate Cancer UK.ResourcesLancet Anti-depressants and physiological side effectsBMJ Knee OA and Best ExercisesNEJM Knee pain and home exercisesBMJ PSA testing trends in EnglandPCUK PSA Consensus statement 2024PCUK Guide for Counselling Patients on the PSA Blood TestPCUK Online Educationwww.nbmedical.com/podcast