<description>&lt;p&gt;Parmita Mishra is a computational biologist and the founder &amp; CEO of &lt;strong&gt;Precigenetics&lt;/strong&gt;, a company aiming to become a rocket to precision medicine.&lt;/p&gt; &lt;p&gt;Parmita is deeply knowledgeable about cutting-edge biology, particularly epigenetics — how behavior and environment can affect gene function without altering genetic code. Her passion for advancing our understanding of diseases is inspiring (and contagious: OSV is an investor in Parmita’s company!)&lt;/p&gt; &lt;p&gt;In our conversation, Parmita and I discuss everything from the curious case of male baldness to how her parents have saved 50,000 lives. &lt;/p&gt; &lt;p&gt;I hope you enjoy this conversation as much as I did. For the full transcript, highlights, and bucketloads of other goodies designed to make you go, “&lt;span class="notion-enable-hover" data-token-index="1"&gt;Hmm, that’s interesting!”,&lt;/span&gt; check out our &lt;a class= "notion-link-token notion-focusable-token notion-enable-hover" tabindex="0" href= "https://8ca54796.streaklinks.com/CJPd0z7cXCh07hc4JAiMaKTC/https%3A%2F%2Fnewsletter.osv.llc%2F" rel="noopener noreferrer" data-token-index="3"&gt;&lt;span class= "link-annotation-unknown-block-id-1875861227"&gt;Substack&lt;/span&gt;&lt;/a&gt;.&lt;/p&gt; &lt;p&gt;&lt;strong&gt;Important Links:&lt;/strong&gt;&lt;/p&gt; &lt;ul&gt; &lt;li&gt;&lt;a href= "https://www.linkedin.com/in/parmitamishra"&gt;LinkedIn&lt;/a&gt;&lt;/li&gt; &lt;li&gt;&lt;a href= "https://x.com/prmshra?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5Eauthor"&gt; Twitter&lt;/a&gt;&lt;/li&gt; &lt;li&gt;&lt;a href="https://t.co/JLb0CGEi4s"&gt;Website&lt;/a&gt;&lt;/li&gt; &lt;li&gt;&lt;a href="https://x.com/precigenetic"&gt;Precigenetics Twitter&lt;/a&gt;&lt;/li&gt; &lt;li&gt;&lt;a href= "https://x.com/prmshra/status/1796964960045539468"&gt;Preciginetics launch post&lt;/a&gt;&lt;/li&gt; &lt;/ul&gt; &lt;p&gt;&lt;strong&gt;Show Notes:&lt;/strong&gt;&lt;/p&gt; &lt;ul&gt; &lt;li&gt;Explaining epigenetics to a golden retriever&lt;/li&gt; &lt;li&gt;The curious case of male pattern baldness&lt;/li&gt; &lt;li&gt;How to think about biology: start from first principles &amp; beware binary thinking&lt;/li&gt; &lt;li&gt;The lens you look through determines what you see&lt;/li&gt; &lt;li&gt;The problem of data collection in biology&lt;/li&gt; &lt;li&gt;Why the FDA needs to change its approach&lt;/li&gt; &lt;li&gt;Why we still don’t understand the human brain&lt;/li&gt; &lt;li&gt;Garry Tan’s advice: “Get an idea. Get a co-founder.”&lt;/li&gt; &lt;li&gt;What’s been surprising about foundership?&lt;/li&gt; &lt;li&gt;Failure is a ladder&lt;/li&gt; &lt;li&gt;Obsession &amp; how Parmita’s parents have saved 50,000 lives&lt;/li&gt; &lt;li&gt;The most surprising things about America&lt;/li&gt; &lt;li&gt;Parmita as World Empress&lt;/li&gt; &lt;/ul&gt; &lt;p&gt;&lt;strong&gt;Books Mentioned:&lt;/strong&gt;&lt;/p&gt; &lt;ul&gt; &lt;li&gt;What is Life?; by Erwin Schrodinger&lt;/li&gt; &lt;li&gt;&lt;a href="https://jsomers.net/i-should-have-loved-biology/"&gt;I should have loved biology&lt;/a&gt;; by James Somers&lt;/li&gt; &lt;li&gt;Gödel, Escher, Bach: An Eternal Golden Braid; by Douglas Hofstadter&lt;/li&gt; &lt;li&gt;The Hypomanic Edge: The Link Between (A Little) Craziness and (A Lot of) Success in America; by John D. Gartner&lt;/li&gt; &lt;/ul&gt;</description>

Infinite Loops

Jim O'Shaughnessy

Parmita Mishra — How to Think About Biology (EP.244)

NOV 28, 202490 MIN
Infinite Loops

Parmita Mishra — How to Think About Biology (EP.244)

NOV 28, 202490 MIN

Description

Parmita Mishra is a computational biologist and the founder & CEO of Precigenetics, a company aiming to become a rocket to precision medicine.

Parmita is deeply knowledgeable about cutting-edge biology, particularly epigenetics — how behavior and environment can affect gene function without altering genetic code. Her passion for advancing our understanding of diseases is inspiring (and contagious: OSV is an investor in Parmita’s company!)

In our conversation, Parmita and I discuss everything from the curious case of male baldness to how her parents have saved 50,000 lives. 

I hope you enjoy this conversation as much as I did. For the full transcript, highlights, and bucketloads of other goodies designed to make you go, “Hmm, that’s interesting!”, check out our Substack.

Important Links:

Show Notes:

  • Explaining epigenetics to a golden retriever
  • The curious case of male pattern baldness
  • How to think about biology: start from first principles & beware binary thinking
  • The lens you look through determines what you see
  • The problem of data collection in biology
  • Why the FDA needs to change its approach
  • Why we still don’t understand the human brain
  • Garry Tan’s advice: “Get an idea. Get a co-founder.”
  • What’s been surprising about foundership?
  • Failure is a ladder
  • Obsession & how Parmita’s parents have saved 50,000 lives
  • The most surprising things about America
  • Parmita as World Empress

Books Mentioned:

  • What is Life?; by Erwin Schrodinger
  • I should have loved biology; by James Somers
  • Gödel, Escher, Bach: An Eternal Golden Braid; by Douglas Hofstadter
  • The Hypomanic Edge: The Link Between (A Little) Craziness and (A Lot of) Success in America; by John D. Gartner