<p>In this episode of Inflammatory Content, Dr. Kellen Cavagnero dives into a landmark 2024 Nature study by Thierry Nordman and colleagues, titled “Spatial proteomics identifies JAKi as treatment for a lethal skin disease.” This cutting-edge research changes the game for patients suffering from toxic epidermal necrolysis (TEN)—a devastating cutaneous adverse drug reaction with limited treatment options.</p><p><br></p><p>Using a powerful approach including spatial proteomics and mouse models of TEN, the authors identify interferon signaling as a key inflammatory pathway driving TEN. Most remarkably, they repurpose an FDA-approved JAK inhibitor to safely and effectively treat patients with TEN in a small clinical trial.</p><p><br></p><p>This episode is a must-listen for anyone interested in how ‘omics technologies can rapidly unlock therapies for even the rarest and most lethal diseases.</p><p><br></p><p>Relevant Links:</p><p>• Paper: https://pubmed.ncbi.nlm.nih.gov/39415009/</p><p>• Commentary: https://pubmed.ncbi.nlm.nih.gov/39501097/</p><p><br></p><p>If you enjoy Inflammatory Content and want to help me keep the conversations going, consider supporting the podcast! You can write a review, share this episode with friends and colleagues, or make a donation to help keep the show ad-free and thriving. Your contributions, big or small, go directly toward covering production costs and allow me to bring you even more Inflammatory Content. You can donate directly here: https://venmo.com/Kellen-Cavagnero.</p><p><br></p><p>I’d love to hear from you! Feel free to reach out with questions, feedback, or topic suggestions via email at [email protected], on X @KellenCavagnero, or connect with me on LinkedIn.</p><p><br></p><p>Stay curious and keep exploring at www.inflammatorycontent.com. </p>