<p>We've been searching for a fountain of youth for millennia. How can we not only live longer, but live healthier for longer?</p><p>Nicotinamide adenine dinucleotide (NAD) is the latest anti-ageing candidate under the microscope.</p><p>Norman and Tegan explain what it is, and whether supplements promising to boost NAD actually do what's advertised on the bottle.</p><p>References:</p><ul><li><a href="https://www.nature.com/articles/s41580-020-00313-x">NAD+ metabolism and its roles in cellular processes during ageing</a></li><li><a href="https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30502-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1550413119305029%3Fshowall%3Dtrue#">NAD+ in Brain Aging and Neurodegenerative Disorders</a></li><li><a href="https://www.science.org/doi/10.1126/sciadv.adi4862">What is really known about the effects of nicotinamide riboside supplementation in humans</a></li><li><a href="https://academic.oup.com/biomedgerontology/article-abstract/78/12/2435/7126788?redirectedFrom=fulltext&login=true">Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions</a></li><li><a href="https://www.nature.com/articles/s41514-023-00134-0">The use of a systems approach to increase NAD+ in human participants</a></li><li><a href="https://pubmed.ncbi.nlm.nih.gov/24811750/">Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging</a></li></ul>