Vets First Podcast

In this episode of the Vets First Podcast, hosts Dr. Levi Sowers and Brandon Rea interview Dr. Oliver Gramlich, a research health science specialist at the Iowa City VA Health Care System. He is also a research assistant professor in the Neuroscience and Pharmacology Program at the University of Iowa. 

Dr. Gramlich was born in Frankfurt, Germany, and went to graduate school at the University of Mines, where he was interested in biology and ophthalmology. After he obtained his PhD, he was recruited to the University of Iowa to work on glaucoma-related vision loss at the Department of Ophthalmology. This led him to become interested in many other vision-related diseases surrounding the optic nerve, such as multiple sclerosis and traumatic brain injury (TBI). 

Throughout the beginning of the episode, Dr. Gramlich narrates his journey to neuro-ophthalmology research at the University of Iowa and his preclinical research at the VA. He discusses the importance of using animal models to translate physiological knowledge from experiments to human subjects. He later talks about the importance of the optic nerve in visual information transmission and elaborates about the physiological mechanisms and effects of various diseases such as glaucoma and multiple sclerosis. 

In the second half of the episode, Dr. Gramlich discusses potential treatments for vision-related diseases. He then talks about his work regarding biomarkers of the visual system that relate to humans and describes potential ways to enhance recovery in patients dealing with optic neuritis. Dr. Gramlich shares his work with utilizing a combination of different diets and drugs to manipulate metabolic pathways in order to promote neuroprotective and anti-inflammatory effects to remedy optic nerve inflammation. Lastly, he describes his use of three-dimensional imaging to observe disease progression and resolution based on multiple variables and how this can directly apply to the clinical side of vision.

In this episode of the Vets First Podcast Dr. Levi Sowers and Brandon Rea interview Elizabeth Holmes. Elizabeth “Liz” Holmes is the Blinded Veterans Association National Secretary and is part of the Georgia regional group. She is an Army Veteran and during her career she attended both basic and advanced ordinance courses and airborne school. Liz was born and raised in the south side of Chicago about 15 minutes from Indiana. She went to DePaul University and didn’t initially have plans to join the military. However, seeing that the ROTC program there did not have any women and knowing she could do anything a man could, Liz decided to join the ROTC program in 1975 and received her training at Fort Riley, Kansas. Following college, she joined the service as a reserve officer and then went on active duty for 11 years where she traveled all over the states, Korea, and Germany. Liz served from 1976 to 1987, where in 1976 she was commissioned to be a Second Lieutenant in the ordinant specialty. Following her military service, Liz worked in the United States Postal Service serving in a variety of different ways until retirement in 2014 due to vision loss because of glaucoma. She had never noticed a change in her vision until she went to an eye exam where her glaucoma was diagnosed. Liz had surgery on her left eye but continued to experience issues. She began seeing a specialist that worked to save her right eye’s vision. Liz was referred to the VA for further care and joined other programs to help navigate life with vision loss. While in blind rehabilitation in Birmingham, Alabama, Liz joined the Blinded Veterans Association and became an active member. She shares about her experiences in the military, vision loss with glaucoma, and her involvement in the Blinded Veterans Association.

In this episode Dr. Levi Sowers and Brandon Rea interview returning guest Dr. Randy Kardon. Dr. Kardon is a neuro ophthalmologist at the Iowa City VA Healthcare System and the University of Iowa in Iowa City who has had federal funding for over 30 years. This episode focuses on diabetic neuropathy and diabetic retinopathy. Diabetes affects many different types of body tissues, including the eye. With minimal invasiveness, the eye can be studied and provide information about how diabetes damages other tissues. Additionally, the eye can allow doctors to detect diabetes far earlier than other tissues with high resolution scans on the cells in the eyes. Early detection and management of diabetes can help minimize health effects of the disease and can prevent blindness. Control of blood sugar is the most important aspect to help prevent blindness with diabetes. Dr. Kardon explains how diabetes affects the eye and can lead to vision loss, as well as other effects on the body and available treatments. He explains that there are tiny blood vessels in the eye that are lined with endothelial cells. In diabetes these endothelial cells are damaged by the byproducts of high blood sugar and cause the tiny blood vessels to leak fluid into the tissue. When fluid gets into the tissue layers it disrupts the tissues' ability to function. This, however, can be managed with treatment. After the vessels begin leaking, the eye releases growth factors to allow new blood vessels to grow. Unfortunately, these vessels are weaker and begin to leak even more, and this is what leads to severe blindness in patients. Though there are treatments for the second stage of blood vessel leaks, when the leakage is too severe there is little that can be done. Dr. Kardon also talks about the different types of diabetes and how each type affects vision in patients.