The Holistic GLP-1 Podcast with Elizabeth McGann

In this episode, I’m joined by Dr. Mike Israetel—PhD in sports physiology, bodybuilder, and one of the most respected voices in muscle, metabolism and body composition. If you’re using (or considering) a GLP-1, this conversation could completely change how you approach your results.We get into what most people are missing: why GLP-1s alone aren’t enough—and how the real magic happens when you combine them with the right nutrition and strength training. Dr. Mike breaks down how you can lose fat without losing muscle (and even build muscle) with just two short workouts a week, why intermittent fasting can backfire, and what’s actually happening when these medications “stop working.”We also talk about bone health, protein intake, side effects, and the future of next-generation GLP-1s.This is one of those episodes that brings clarity, cuts through the noise, and gives you a smarter, more empowered way to do this right.***SHOW NOTES[ 00:00 ] Welcome + Why This Episode Matters[ 04:00 ] The Biggest GLP-1 Mistake Almost Everyone Is Making[ 08:00 ] The Muscle Myth: Why Weight Loss Without Strength Training Backfires[ 12:00 ] The 2x20-Minute Workout That Changes Everything[ 16:00 ] Gym Intimidation: How to Start (Even If You’ve Never Lifted)[ 20:00 ] Yoga, Pilates & Walking: Are They Enough?[ 24:00 ] The Truth About Bone Loss on GLP-1s[ 28:00 ] The Ideal GLP-1 Nutrition Strategy (That Most People Miss)[ 32:00 ] Intermittent Fasting on GLP-1s: Helpful or Harmful?[ 36:00 ] Hitting Your Protein Goals (Even If You’re Busy or Plant-Based)[ 40:00 ] GLP-1 “Tolerance”: Are the Drugs Stopping Working?[ 44:00 ] Dosing Strategy: Why “Start Low, Go Slow” Wins[ 48:00 ] Side Effects Explained: What’s Actually Happening in Your Body[ 52:00 ] The “Flat Feeling”: Is GLP-1 Killing Joy?[ 56:00 ] The Future of GLP-1s: What’s Coming Next***🔥 Key TakeawayGLP-1s aren’t a shortcut—they’re a force multiplier.When combined with smart nutrition and resistance training, they unlock a level of transformation that most people never reach.***Get Connected with Elizabeth McGann:Coaching Website: http://www.ElizabethMcGann.comInstagram: http://www.instagram.com/elizabethmcgannFacebook: https://www.facebook.com/ElizabethMcGannWellnessLinkedIn: https://www.linkedin.com/in/elizabethmcgannX/Twitter: https://twitter.com/ElizabethMcGann***Learn more about Dr. Mike IsraetelNew Book The Aesthetic Revolution: https://www.amazon.com/Aesthetic-Revolution-Embracing-Fitness-Healthiest/dp/1538779846YouTube: https://www.youtube.com/channel/UCfQgsKhHjSyRLOp9mnffqVgInstagram: https://www.instagram.com/drmikeisraetel/Website for RP Strength/Renaissance Periodization: https://rpstrength.com/

In this solo "mini-sode," Elizabeth McGann powerfully challenges one of the most common—and potentially harmful—misconceptions in the GLP-1 conversation: that hunger should disappear entirely. Drawing from her experience as a holistic nutritionist, Elizabeth reframes hunger not as the enemy, but as an essential signal the body needs to function, heal and thrive.She explores how over-reliance on GLP-1 medications can lead to disconnection from the body, loss of muscle, and long-term setbacks—and offers a more sustainable, empowering approach. By combining thoughtful medication use with foundational nutrition, metabolic support, and lifestyle strategies, listeners are invited to discover how to regulate hunger rather than suppress it.If you’re navigating GLP-1s—whether starting, adjusting, or considering a natural approach—this episode offers a mindset shift that could transform your results and your relationship with your body.***[ 0:00 ] Why We Need to Rethink Hunger on GLP-1 Medications[ 3:10 ] Why Chasing Zero Hunger on GLP-1 is Problematic[ 5:40 ] How to Find the Right GLP-1 Dose for Sustainable Weight Release[ 8:20 ] The Importance of Regulating Hunger Holistically for True FreedomGet Connected with Elizabeth McGannCheck out the new Youtube Channel! https://www.youtube.com/@ElizabethMcGannTubeInstagram: https://www.Instagram.com/ElizabethMcGannFacebook: https://www.facebook.com/ElizabethMcGannWellnessLinkedIn: https://www.linkedin.com/in/ElizabethMcGannX: https://twitter.com/ElizabethMcGann

What if the real key to successful, sustainable weight loss isn’t starting a GLP-1—but fixing your gut first?In this eye-opening episode, I sit down with Dr. Oscar Coetzee, a leading expert in clinical nutrition and gut health, to unpack the critical (and often overlooked) role the microbiome plays in metabolism, cravings, and natural GLP-1 production.We explore why starting a GLP-1 with poor gut health can backfire, how specific bacteria influence hunger hormones and dopamine, and the emerging science behind “keystone” microbes that may control up to 85% of your metabolic function.If you’re considering a GLP-1, currently on one, or looking for a more natural, root-cause approach to weight loss—this conversation is essential.This episode will change how you think about your gut—and your path to lasting results.***SHOW NOTES[ 00:00 ] Introduction: A Critical Warning Before Starting GLP-1[ 04:00 ] Is the Gut Actually the First Brain?[ 08:00 ] From Psychology to Microbiome Medicine[ 12:00 ] The Microbes That Control Your Hunger Hormones[ 16:00 ] The Gut as an Ecosystem (The “Earthworm” Analogy)[ 20:00 ] Why Probiotics Alone Aren’t Enough[ 24:00 ] The Real Driver of Cravings and Overeating[ 28:00 ] The Fiber Crisis (and Why It Matters)[ 32:00 ] Signs Your Gut Is Holding You Back[ 36:00 ] Functional Testing: The Missing Diagnostic Tool[ 40:00 ] Why “Killing Bad Bacteria” Can Make Things Worse[ 44:00 ] The Breakthrough: Keystone (Anaerobic) Bacteria[ 48:00 ] Case Study: Reversing Food Sensitivities Naturally[ 52:00 ] How Gut Health Directly Drives GLP-1 Production[ 56:00 ] Why GLP-1 Results Plateau (and How to Fix It)[ 1:00:00 ] The 5 Bacteria That Control 85% of Your Metabolism[ 1:04:00 ] The Hidden Cost of GLP-1 Medications[ 1:08:00 ] Testing Your Metabolic Health Beyond the Scale[ 1:12:00 ] The Simplest (and Most Powerful) Gut-Healing Strategy[ 1:16:00 ] Final Takeaways: Build the Foundation First***Get Connected with Elizabeth McGann:Coaching Website: http://www.ElizabethMcGann.comInstagram: http://www.instagram.com/elizabethmcgannFacebook: https://www.facebook.com/ElizabethMcGannWellnessLinkedIn: https://www.linkedin.com/in/elizabethmcgannX/Twitter: https://twitter.com/ElizabethMcGann***Learn more about Dr. Oscar CoetzeeDr. Coetzee's Website: https://naturalhealthcarecenter.comInstagram: https://www.instagram.com/droscarcoetzee/

What if the biggest mistake people are making on GLP-1 medications isn’t the drug—but how they’re using it?In this episode, Elizabeth sits down with leading endocrinologist and 20-year GLP-1 researcher Dr. Zhenqi Liu to unpack the hidden risks of rapid weight loss—including muscle loss, metabolic slowdown, and rebound fat gain—and how to avoid them.If you want to lose weight without sacrificing your metabolism, this conversation is essential.***SHOW NOTES[ 00:00 ] Introduction: The 7-Step GLP-1 Muscle Loss Cycle[ 03:30 ] Why Fast Weight Loss Backfires[ 07:00 ] Malnutrition: The Silent Risk[ 10:30 ] Why the Body Breaks Down Muscle First[ 14:00 ] Muscle Quality vs. Quantity in Obesity[ 17:30 ] Fat Inside Muscle & Metabolic Dysfunction[ 21:00 ] The Turning Point: Protecting Muscle During Weight Loss[ 24:30 ] Who Should Use GLP-1s (and Who Shouldn’t)[ 28:00 ] The Exercise Formula That Changes Everything[ 28:00 ] The Exercise Formula That Changes Everything[ 31:30 ] Cardiovascular Fitness & Longevity[ 35:00 ] Nutrition Mistakes That Undermine Results[ 38:30 ] “Eat Even If You’re Not Hungry”[ 42:00 ] Protein: The Non-Negotiable Nutrient[ 45:30 ] Protein + Strength Training: The Winning Combination[ 49:00 ] Protein Sources, Powders & Amino Acids[ 52:30 ] Are GLP-1s a Long-Term Solution?[ 56:00 ] Lower Doses & Smarter Use[ 59:30 ] The Rebound Effect Explained[ 1:03:00 ] The Most Common Mistakes People Make[ 1:06:30 ] Why Strength Matters More Than the Scale[ 1:10:00 ] Is Obesity a Disease?[ 1:13:30 ] Do You Need GLP-1s for Life?[ 1:17:00 ] The Real Secret to Sustainable Results**Get Connected with Elizabeth McGann:Coaching Website: http://www.ElizabethMcGann.comInstagram: http://www.instagram.com/elizabethmcgannFacebook: https://www.facebook.com/ElizabethMcGannWellnessLinkedIn: https://www.linkedin.com/in/elizabethmcgannX/Twitter: https://twitter.com/ElizabethMcGann***Learn more about Dr. Zhenqi LiuUniversity of Virginia Profile: https://med.virginia.edu/endocrinology-metabolism/research/endocrine-investigators/zhenqi-liu/X/Twitter: https://x.com/DrZhenqiLiu

If you've been hearing about GLP-1 medications and wondering whether they might help you—but you feel nervous, skeptical, or unsure—this episode is a powerful place to begin. In this deeply personal conversation, Elizabeth sits down with GLP-1 advocate and content creator Rachael Gullette, who has lost more than 160 pounds on a GLP-1 medication. Rachael shares what life felt like before treatment, how food noise ruled her inner world, and how discovering that obesity is a disease—not a character flaw—changed everything. This is a raw, hopeful, eye-opening episode about food noise, binge eating, ADHD, shame, stigma, infertility, inflammation, and the kind of freedom that feels almost impossible until you experience it for yourself. *** SHOW NOTES [ 00:00 ] Introduction: A Different Kind of GLP-1 Story [ 03:00 ] "Everything Felt Heavy" [ 06:00 ] When Food Became Comfort, Dopamine, and Survival [ 09:00 ] Dieting Young, Without Understanding Why [ 12:00 ] The Discovery That Changed Everything: Obesity Is a Disease [ 15:00 ] Food Noise: What It Really Feels Like [ 15:00 ] "Someone Flipped a Switch" [ 21:00 ] ADHD, Binge Eating, and the Addiction Connection [ 24:00 ] The Early GLP-1 Community and the Stigma They Faced [ 27:00 ] TikTok Bans, Censorship, and Speaking Up Anyway [ 30:00 ] Obesity, Addiction, and Food Noise Exist on a Spectrum [ 33:00 ] A Hyper-Responder to GLP-1s [ 36:00 ] 160 Pounds Lost… and a Miracle Pregnancy [ 39:00 ] "It Is Not Your Fault" [ 42:00 ] Oprah, Public Stigma, and Why the Conversation Is Changing *** Get Connected with Elizabeth McGann: Coaching Website: http://www.ElizabethMcGann.com Instagram: http://www.instagram.com/elizabethmcgann Facebook: https://www.facebook.com/ElizabethMcGannWellness LinkedIn: https://www.linkedin.com/in/elizabethmcgann X/Twitter: https://twitter.com/ElizabethMcGann *** Learn more about Rachael Gullette Instagram: https://www.instagram.com/lovenestconversation/?hl=en Linktree: https://linktr.ee/lovenestconversation