<p>👇 ALL MY LINKS IN ONE PLACE</p><p>https://hunterwilliamshealth.com/links</p><p><br></p><p>Low-dose naltrexone is one of my favorite compounds out there, and in this updated 2026 episode I&#39;m breaking down why it deserves a spot in your protocol. I cover the four mechanisms that make LDN work: the endorphin rebound, the OGF/OGFR axis, TLR4 antagonism, and broad anti-inflammatory signaling. Then I get into where LDN actually shines clinically. Autoimmune conditions like Hashimoto&#39;s and Crohn&#39;s. Chronic pain and fibromyalgia. Depression. PCOS and fertility. Even skin issues like acne, which I&#39;ve personally dealt with for years.</p><p>But the part I&#39;m most excited about is how LDN stacks with hormones and peptides. I walk through why it pairs so well with TRT, estrogen, and thyroid optimization, and then I get into specific peptide combos including BPC-157, TB-500, thymosin alpha-1, KPV, SS-31, and GLP-1 agonists. I also share why LDN might let you stay at lower GLP-1 doses for longer.</p><p>I cover dosing, titration, side effects, and my own experience cycling versus staying on continuously. If you&#39;re already optimizing with peptides and hormones, LDN might be that last five to ten percent that makes everything else work better.</p><p>00:00 – Intro and why LDN deserves an updated episode</p><p>02:22 – Why LDN belongs in your protocol (40-year safety record, broad benefits)</p><p>03:44 – The history of LDN and Dr. Bernard Bihari&#39;s HIV discovery</p><p>05:42 – The four mechanisms of action explained</p><p>06:30 – The OGF/OGFR axis and cancer applications</p><p>07:30 – TLR4 antagonism and the immune benefits</p><p>09:24 – Where LDN shines: autoimmune, pain, gut, depression, PCOS, skin</p><p>13:14 – Dosing, titration, and timing (night vs morning)</p><p>15:06 – Side effects, contraindications, and safety</p><p>16:14 – LDN and hormone replacement therapy synergy</p><p>18:34 – LDN for men on TRT, sexual function, and cortisol</p><p>20:48 – LDN stacked with peptides (BPC-157, TB-500, KPV, SS-31, GLP-1s, TA-1)</p><p>28:38 – My personal take on cycling vs daily use</p><p>30:16 – Closing thoughts</p><p><br><strong>Timestamps</strong><br></p>