<p>All links here: <a href="https://hunterwilliamshealth.com/links" target="_blank" rel="ugc noopener noreferrer">https://hunterwilliamshealth.com/links</a></p><p><br></p><p>00:00 — Intro and why I&#39;m doing these masterclasses</p><p>02:42 — What we&#39;re covering and the regulatory timeline</p><p>04:04 — The two users: weight loss vs longevity</p><p>05:30 — What Retatrutide actually does (the three receptors)</p><p>06:50 — Why the glucagon receptor makes Retatrutide different</p><p>07:54 — Weight loss trial data (1mg to 12mg)</p><p>10:50 — The longevity data: liver fat, ApoB, blood pressure</p><p>13:14 — Who the lean biohacker user is</p><p>13:50 — The titration playbook</p><p>15:32 — Once weekly vs split dosing</p><p>19:50 — Morning vs night injections</p><p>21:02 — How far to push the dose (why 8mg is the ceiling)</p><p>22:50 — How long to stay on and the regain problem</p><p>25:44 — Longevity maintenance protocol</p><p>26:34 — Lean user protocol</p><p>27:24 — Protein and training are non-negotiable</p><p>29:06 — Side effects and how to manage them</p><p>30:20 — The heart rate question and why I use taurine</p><p>32:00 — The weird skin sensitivity issue</p><p>33:48 — Pairing Retatrutide with testosterone</p><p>35:56 — Drug interactions (blood pressure, thyroid, insulin)</p><p>37:02 — Metrics that matter</p><p>38:42 — How to cycle off correctly</p><p>39:54 — The most common mistakes</p><p>40:42 — How to start, what to do if you plateau</p><p>43:04 — Should you switch from Tirzepatide?</p><p>45:28 — Combining Retatrutide with other peptides</p><p>46:50 — The Ten Commandments of Retatrutide use</p><p>47:50 — The bottom line</p><p><br></p><p>Today&#39;s episode is the first in a new format I&#39;m rolling out. I&#39;m working on a book where I cover one peptide at a time, one chapter at a time. Alongside that, I wanted to do a masterclass on each peptide and condense down everything I know into one place. First up is Retatrutide.</p><p>I cover what it actually does in your body, the two very different users that should be on it, and the dosing strategies that get debated to death online. We go through the weight loss data, the longevity data, and why I think 8 milligrams is the real ceiling for most people. I also break down once weekly versus split dosing, the heart rate question, the skin sensitivity issue, and why testosterone optimization has to come first.</p><p>If you want a definitive guide on Retatrutide, this is it. My goal is that you walk away with a framework you can actually use, whether it&#39;s on yourself, your coaching clients, or your patients.</p><p>Let me know what you think. I plan on doing many more of these on every peptide that matters.</p><p><br></p><p>⚠️ For research and entertainment purposes only. ⚠️</p>