In February 2020, an elite group of biosecurity experts, worried about the threat of pandemics, plays a bizarrely prescient role-playing game. They run into an age-old pattern of secrecy and mistrust, one that thwarts their efforts to ‘beat’ the game. We travel back to a (real-life) period when dozens of mysterious deaths occurred in a closed Soviet city. As it turns out, hidden pieces of lung tissue help shed light on what, to this day, keeps the nations of the world from working together to fight infectious disease.