<p>During the <a href="https://mpn-hub.com/congresses/ash/ash-2025" rel="noopener noreferrer" target="_blank">67th American Society of Hematology (ASH) Annual Meeting and Exposition</a>, December 6–9, 2025, Orlando, US, the MPN Hub was pleased to speak with <a href="https://mpn-hub.com/contributors/claire-harrison" rel="noopener noreferrer" target="_blank">Claire Harrison</a>, Guy’s and St Thomas’ NHS Foundation Trust, London, UK. We asked, What are the latest findings from the phase&nbsp;I/II study of <a href="https://mpn-hub.com/therapeutics/kinase-inhibitors/nuvisertib" rel="noopener noreferrer" target="_blank">nuvisertib</a> in combination with <a href="https://mpn-hub.com/therapeutics/jak-inhibitors/momelotinib" rel="noopener noreferrer" target="_blank">momelotinib</a> in patients with <a href="https://mpn-hub.com/types/myeloproliferative-neoplasms/relapsedrefractory-myelofibrosis" rel="noopener noreferrer" target="_blank">relapsed/refractory myelofibrosis</a> (R/R MF)?</p><br><p>In this interview, Harrison discusses key findings from Arm 3 of the trial (<a href="https://clinicaltrials.gov/study/NCT04176198" rel="noopener noreferrer" target="_blank">NCT04176198</a>), which enrolled patients who had been previously treated with a <a href="https://mpn-hub.com/therapeutics/jak-inhibitors" rel="noopener noreferrer" target="_blank">Janus kinase inhibitor</a> (JAKi) other than momelotinib. The study aimed to identify the recommended phase&nbsp;II dose (RP2D) of nuvisertib when administered in combination with momelotinib, and to assess the safety, clinical activity (spleen volume reduction [SVR] and total symptom score [TSS] improvement), and pharmacokinetics and pharmacodynamic markers (including cytokines and bone marrow fibrosis).</p><br><p><em>This educational resource is independently supported by Sumitomo. All content was developed by SES in collaboration with an expert steering committee. Funders were allowed no influence on the content of this resource.</em></p><hr><p style='color:grey; font-size:0.75em;'> Hosted on Acast. See <a style='color:grey;' target='_blank' rel='noopener noreferrer' href='https://acast.com/privacy'>acast.com/privacy</a> for more information.</p>