There are only a few topics women in their forties can’t stop talking about right now: perimenopause, hormone replacement therapy, and GLP medications. In this episode, we sit down with physician Dr. Mary Brandon for a no-bullshit conversation about what’s actually happening in our bodies—and why so many of us feel like we’re losing our minds. We break down how GLP medications really work (and why many women feel better on them beyond weight loss), the role inflammation plays in joint pain, sleep, mood, and energy, and what the next generation of these drugs could look like. We also get into hormone replacement therapy—what it actually does, why testosterone is so often ignored in women’s care, and how decades of fear, shame, and misinformation have made this phase of life harder than it ever needed to be. Follow Dr. Brandon's practice here. Follow Dr. Brandon here. Join our newsletter community here. ORDER The Parisian Heist here. Visit our lovely sponsors here. Learn more about your ad choices. Visit podcastchoices.com/adchoices