Modern Healthspan

Dr. DanPardi explains why creatine supplementation may help preserve cognitivefunction during sleep deprivation, aging, and high mental demand, plus thespecific dosing strategies most people miss. In thisconversation, Dr. Dan Pardi breaks down the emerging science of creatine forbrain health. While creatine is famous for athletic performance, new researchshows it may help maintain cognitive function under stress, particularly duringsleep deprivation, travel, and aging. Dr. Pardi explains the mechanisms: howcreatine acts as an energy buffer in the brain, why it works best under fatigueor high demand, and which cognitive functions respond most consistently(working memory, processing speed, sustained attention). We cover practicaldosing strategies, including why 5 grams daily may not be enough for brainbenefits, the role of loading phases, and the specific high-dose protocolstudied for sleep deprivation. This isn't about cognitive enhancement; it'sabout preservation. If you're interested in maintaining brain performance asyou age, dealing with poor sleep, or supporting cognitive resilience, thisconversation offers actionable strategies backed by research. 🌐Linksin this video Qualia LifeSciences web page https://www.qualialife.com/Human OSwebsite https://humanos.me *Qitone*(10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters PowderSeekingHealth supplements: 10% discount code Richard10https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrientshttps://crrnt.app/SEEK/EpM7paAOAX3 LifeAstaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comStemregen 15%discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Scienceall 10% discount with code MHS https://renuebyscience.com/  Nuchido Time+ 20% discount offirst purchase with code MODERN20 https://nuchido.com/MODERNIf you would like tosupport our channel please consider signing up on patreonhttps://patreon.com/ModernHealthspanYou can also find us onYouTube at https://www.youtube.com/c/modernhealthspan

Dr. Allen Taylor spent 40 years at Tufts discovering how diet affects vision. Learn why high glycemic foods accelerate macular degeneration and cataracts—and what you can do to protect your eyes.Dr. Allen Taylor directed the Laboratory for Nutrition and Vision Research at Tufts University for four decades, pioneering groundbreaking discoveries about how nutrition impacts age-related eye diseases. In this comprehensive interview, he reveals how high glycemic diets create a "double jeopardy" in your eyes—damaging proteins while simultaneously destroying your cellular cleanup systems.Dr. Taylor explains the cellular mechanisms behind age-related macular degeneration (AMD) and cataracts, breaking down complex biochemistry into actionable insights. You'll learn about the epidemiological evidence linking Western diets to AMD risk, why blood sugar spikes matter even for non-diabetics, and how advanced glycation end products (AGEs) accumulate in retinal tissue.The conversation covers practical strategies including which antioxidants matter most (vitamin C, vitamin E, lutein), why omega-3 fatty acids support retinal health, and how switching from high to low glycemic foods could prevent 100,000 cases of blinding AMD annually. Dr. Taylor also discusses his current intervention trial testing whether people with early AMD can preserve vision through dietary changes.Key topics: macular degeneration, cataracts, glycemic index, nutrition and vision, eye health, aging, preventive medicine, antioxidants, drusen, photoreceptor health, retinal pigment epithelium, and practical dietary interventions for longevity🌐Links in this video Dr Taylor's page at Tufts https://facultyprofiles.tufts.edu/allen-taylor The review mentioned by Dr Taylor: Glycative stress as a cause of macular degeneration Full Version: https://tinyurl.com/bdp3u93f Summary Version: https://tinyurl.com/yj2zmx5n*Qitone* (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters PowderSeeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAOAX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comStemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERNIf you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspanYou can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Your ferritin test doesn't measure what you think. Dr. Douglas Kell explains iron dysregulation, dormant microbes, and his controversial theory about chronic diseaseDr. Douglas Kell, systems biologist at the University of Liverpool, presents his research on iron dysregulation and its potential role in chronic inflammatory diseases. In this conversation, he explains why ferritin in blood is actually a marker of cell death rather than iron storage, how free iron can trigger oxidative stress through the Fenton reaction, and his hypothesis about dormant bacteria and amyloidogenic microclots. We discuss practical interventions including what iron tests actually matter (transferrin saturation over ferritin), natural compounds like ergothioneine from mushrooms that showed dramatic protective effects in studies, and enzymes like nattokinase that may help address abnormal clotting. Dr. Kell also covers his work on pre-eclampsia, the connection between iron and neurodegenerative diseases, and why he views most chronic inflammatory diseases through a systems biology lens. While his full IDDM (Iron Dysregulation and Dormant Microbes) hypothesis remains contested, the practical information on iron management and oxidative stress provides actionable insights for healthy aging.🌐Links in this video Dr Kell's page at University of Liverpool https://www.liverpool.ac.uk/people/douglas-kell DBK Group's web page with all Dr Kell's publications https://dbkgroup.org/*Qitone* (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters PowderSeeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAOAX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comStemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERNIf you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspanYou can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Dr. Eric Plaisance explains how exogenous ketones may provide fasting benefits without dietary restriction - the hormetic effects of mimicking starvation while fed. Plus: ketone salts vs esters, his personal protocol, and why performance claims don't hold up.Dr. Eric Plaisance, Associate Professor at University of Alabama Birmingham, has spent over a decade studying exogenous ketone esters. His most intriguing finding? Ketones may allow us to "mimic a starvation environment when we're not starving" - potentially triggering the same hormetic benefits as fasting without dietary restriction. In this conversation, we explore the anti-inflammatory effects of ketones, the promising research in liver health and cancer, and the practical differences between ketone salts, esters, and MCT oil. Dr. Plaisance shares his personal ketone protocol (including why he takes them before workouts during time-restricted eating), optimal dosing strategies, and why the athletic performance marketing claims don't match the research. We also discuss who should actually consider ketone supplementation versus who should save their money. A grounded, evidence-based perspective on one of longevity's most debated supplements.🌐Links in this video Dr Plaisance's page at Alabama University https://scholars.uab.edu/2392-eric-plaisance*Qitone* (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters PowderSeeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAOAX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comStemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERNIf you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspanYou can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Dr. Mary Newport shares groundbreaking research analyzing cholesterol profiles across 40 years of studies, challenging conventional wisdom about saturated fat and heart health. We discuss her findings on MCT oil for brain health, the 288 caregiver reports showing cognitive improvements, and practical protocols for using coconut oil and ketones.Dr. Mary Newport, physician and Alzheimer's researcher, joins us to discuss her latest research that challenges decades of assumptions about coconut oil and saturated fat. In this interview, we explore: • Her comprehensive analysis of 26 studies spanning 40 years (984 lipid profiles) showing coconut oil's unexpected effects on cholesterol • The 288 caregiver reports documenting improvements in memory, cognition, and daily function • How medium-chain triglycerides (MCTs) may provide an alternative fuel source for aging brains • Practical protocols for incorporating coconut oil and MCT oil into your diet • The controversial history of dietary fat guidelines and the trans fat problem • Why the medical establishment has been slow to acknowledge ketone research Dr. Newport's work began with her husband Steve's dramatic response to coconut oil after his early-onset Alzheimer's diagnosis. Her research has since expanded to include hundreds of case reports and comprehensive lipid analysis.🌐Links in this video 🔗 Dr. Newport's website: https://coconutketones.com/ Coalition for Metabolic Health https://coalitionformetabolichealth.org/ Analysis of 26 Studies of the Impact of Coconut Oil on Lipid Parameters: Beyond Total and LDL Cholesterol https://www.mdpi.com/2072-6643/17/3/514 Ketogenic strategies for Alzheimer’s disease and other memory impairments: History, rationale, and 288 caregiver case reports https://esmed.org/MRA/mra/article/view/5316Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAOAX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comStemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERNIf you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspanYou can also find us on YouTube at https://www.youtube.com/c/modernhealthspan