Takeaways:Slimmer's Paralysis is a recognized condition.Ethical boundaries are crucial in patient relationships.Medical professionals must maintain professionalism at all times.Humor can sometimes arise in serious discussions.Patient stories should always be handled with care.The importance of clear communication in medical settings.Understanding patient experiences is vital for effective care.Ethics in medicine is a complex and nuanced topic.Medical discussions can lead to unexpected topics.Maintaining a professional demeanor is essential.   Hosted by Simplecast, an AdsWizz company. See <a href="https://pcm.adswizz.com">pcm.adswizz.com</a> for information about our collection and use of personal data for advertising.

<description>&lt;p&gt;Takeaways:&lt;/p&gt;&lt;p&gt;Slimmer's Paralysis is a recognized condition.&lt;/p&gt;&lt;p&gt;Ethical boundaries are crucial in patient relationships.&lt;/p&gt;&lt;p&gt;Medical professionals must maintain professionalism at all times.&lt;/p&gt;&lt;p&gt;Humor can sometimes arise in serious discussions.&lt;/p&gt;&lt;p&gt;Patient stories should always be handled with care.&lt;/p&gt;&lt;p&gt;The importance of clear communication in medical settings.&lt;/p&gt;&lt;p&gt;Understanding patient experiences is vital for effective care.&lt;/p&gt;&lt;p&gt;Ethics in medicine is a complex and nuanced topic.&lt;/p&gt;&lt;p&gt;Medical discussions can lead to unexpected topics.&lt;/p&gt;&lt;p&gt;Maintaining a professional demeanor is essential.&lt;/p&gt;&lt;p&gt; &lt;/p&gt;&lt;p&gt; &lt;/p&gt;&lt;br/&gt; &lt;p&gt;Hosted by Simplecast, an AdsWizz company. See &lt;a href="https://pcm.adswizz.com"&gt;pcm.adswizz.com&lt;/a&gt; for information about our collection and use of personal data for advertising.&lt;/p&gt;</description>

In this episode, Dr. Spencer and Dr. Karl break down some of the strangest and most misunderstood GLP-1 side effects, from slimmer’s paralysis and foot drop to bladder spasms and post-bariatric reactive hypoglycemia. They walk through real patient cases, why these issues happen, and what clinicians and patients can do to spot them early and manage them safely.

GLP-1 Side Effects Deep Dive: Slimmer's Paralysis, Bladder Spasms, & Reactive Hypoglycemia.

Takeaways:Drug transfer during lactation is complex and challenging.Semaglutide was not detected in women taking any dose.Low amounts of tears epitide were found in milk.Tissue damage can affect drug absorption.Mastitis and engorgement complicate the lactation process.Injections are necessary for effective drug delivery.The analogy of an elephant illustrates the difficulty of drug transfer.Detection of drugs in milk is a critical concern for breastfeeding mothers.Understanding turnover is essential in lactation studies.The implications of drug transfer on women's health are significant. <a href="https://www.infantrisk.com/our-team">Infant Risk Center Link</a>  Hosted by Simplecast, an AdsWizz company. See <a href="https://pcm.adswizz.com">pcm.adswizz.com</a> for information about our collection and use of personal data for advertising.

<description>&lt;p&gt;Takeaways:&lt;/p&gt;&lt;p&gt;Drug transfer during lactation is complex and challenging.&lt;/p&gt;&lt;p&gt;Semaglutide was not detected in women taking any dose.&lt;/p&gt;&lt;p&gt;Low amounts of tears epitide were found in milk.&lt;/p&gt;&lt;p&gt;Tissue damage can affect drug absorption.&lt;/p&gt;&lt;p&gt;Mastitis and engorgement complicate the lactation process.&lt;/p&gt;&lt;p&gt;Injections are necessary for effective drug delivery.&lt;/p&gt;&lt;p&gt;The analogy of an elephant illustrates the difficulty of drug transfer.&lt;/p&gt;&lt;p&gt;Detection of drugs in milk is a critical concern for breastfeeding mothers.&lt;/p&gt;&lt;p&gt;Understanding turnover is essential in lactation studies.&lt;/p&gt;&lt;p&gt;The implications of drug transfer on women's health are significant.&lt;br /&gt;&lt;br /&gt;&lt;a href="https://www.infantrisk.com/our-team"&gt;Infant Risk Center Link&lt;/a&gt;&lt;/p&gt;&lt;p&gt; &lt;/p&gt;&lt;br/&gt; &lt;p&gt;Hosted by Simplecast, an AdsWizz company. See &lt;a href="https://pcm.adswizz.com"&gt;pcm.adswizz.com&lt;/a&gt; for information about our collection and use of personal data for advertising.&lt;/p&gt;</description>

In this episode, we sit down with leading lactation researcher Dr. Kaytlin Krutsch break down the first real human data on GLP-1 medications in breast milk. She explains what the studies found, what women should consider before starting these medications postpartum, and why the actual risk may be far lower than most people think.

GLP-1s and Breast Milk: What the New Research Actually Found

Takeaways:Behavior change is a complex process that requires understanding motivation and discipline.Motivation is not just a feeling; it's a psychological skill that can be developed.Many common phrases about behavior change are misleading and oversimplified.Exercise should be viewed as a choice rather than a habit that becomes automatic.Self-efficacy is crucial for successful behavior change and can be built through mastery experiences.Future self thinking can help individuals align their actions with their long-term goals.It's important to lower barriers to entry for new behaviors to increase adherence.Modeling healthy behaviors is essential for influencing children and adolescents.The psychological definition of a habit differs from the colloquial use of the term.Resources and support systems are vital for individuals looking to change their behaviors.<a href="https://www.instagram.com/karinnordinphd/" target="_blank">Follow Dr. Nordin Here</a><a href="https://bodybrainalliance.com/" target="_blank">https://bodybrainalliance.com/</a> Hosted by Simplecast, an AdsWizz company. See <a href="https://pcm.adswizz.com">pcm.adswizz.com</a> for information about our collection and use of personal data for advertising.

<description>&lt;p&gt;Takeaways:&lt;/p&gt;&lt;p&gt;Behavior change is a complex process that requires understanding motivation and discipline.&lt;/p&gt;&lt;p&gt;Motivation is not just a feeling; it's a psychological skill that can be developed.&lt;/p&gt;&lt;p&gt;Many common phrases about behavior change are misleading and oversimplified.&lt;/p&gt;&lt;p&gt;Exercise should be viewed as a choice rather than a habit that becomes automatic.&lt;/p&gt;&lt;p&gt;Self-efficacy is crucial for successful behavior change and can be built through mastery experiences.&lt;/p&gt;&lt;p&gt;Future self thinking can help individuals align their actions with their long-term goals.&lt;/p&gt;&lt;p&gt;It's important to lower barriers to entry for new behaviors to increase adherence.&lt;/p&gt;&lt;p&gt;Modeling healthy behaviors is essential for influencing children and adolescents.&lt;/p&gt;&lt;p&gt;The psychological definition of a habit differs from the colloquial use of the term.&lt;/p&gt;&lt;p&gt;Resources and support systems are vital for individuals looking to change their behaviors.&lt;/p&gt;&lt;p&gt;&lt;a href="https://www.instagram.com/karinnordinphd/" target="_blank"&gt;Follow Dr. Nordin Here&lt;/a&gt;&lt;/p&gt;&lt;p&gt;&lt;a href="https://bodybrainalliance.com/" target="_blank"&gt;https://bodybrainalliance.com/&lt;/a&gt;&lt;/p&gt;&lt;br/&gt; &lt;p&gt;Hosted by Simplecast, an AdsWizz company. See &lt;a href="https://pcm.adswizz.com"&gt;pcm.adswizz.com&lt;/a&gt; for information about our collection and use of personal data for advertising.&lt;/p&gt;</description>

In this episode, Dr. Spencer and Dr. Karl talk with Dr. Karin Nordin, behavioral change specialist and founder of Body Brain Alliance, about why most advice on motivation, discipline, and habits gets it wrong. They break down the science of behavior change, exploring how identity, self-efficacy, and “future self thinking” can help people finally follow through on healthy routines that last.

How to Build Healthy Routines That Actually Stick

<ul><li>Testosterone therapy can improve libido in postmenopausal women.</li><li>Sexual dysfunction in women is complex and multifactorial.</li><li>Low sexual desire is only considered a disorder if it causes distress.</li><li>Psychosocial factors play a significant role in sexual health.</li><li>Testosterone levels do not change significantly at menopause.</li><li>The placebo effect can significantly influence treatment outcomes.</li><li>Individualized care is crucial in managing sexual dysfunction.</li><li>Dosing for testosterone therapy should be carefully monitored.</li><li>Current medications for low libido have modest benefits.</li><li>Evidence for testosterone therapy in premenopausal women is still emerging. <a href="https://www.instagram.com/professorsusandavis" target="_blank">Tap to Follow Dr.Susan</a></li></ul> Hosted by Simplecast, an AdsWizz company. See <a href="https://pcm.adswizz.com">pcm.adswizz.com</a> for information about our collection and use of personal data for advertising.

<description>&lt;ul&gt;&lt;li&gt;Testosterone therapy can improve libido in postmenopausal women.&lt;/li&gt;&lt;li&gt;Sexual dysfunction in women is complex and multifactorial.&lt;/li&gt;&lt;li&gt;Low sexual desire is only considered a disorder if it causes distress.&lt;/li&gt;&lt;li&gt;Psychosocial factors play a significant role in sexual health.&lt;/li&gt;&lt;li&gt;Testosterone levels do not change significantly at menopause.&lt;/li&gt;&lt;li&gt;The placebo effect can significantly influence treatment outcomes.&lt;/li&gt;&lt;li&gt;Individualized care is crucial in managing sexual dysfunction.&lt;/li&gt;&lt;li&gt;Dosing for testosterone therapy should be carefully monitored.&lt;/li&gt;&lt;li&gt;Current medications for low libido have modest benefits.&lt;/li&gt;&lt;li&gt;Evidence for testosterone therapy in premenopausal women is still emerging.&lt;br /&gt;&lt;br /&gt;&lt;a href="https://www.instagram.com/professorsusandavis" target="_blank"&gt;Tap to Follow Dr.Susan&lt;/a&gt;&lt;/li&gt;&lt;/ul&gt;&lt;br/&gt; &lt;p&gt;Hosted by Simplecast, an AdsWizz company. See &lt;a href="https://pcm.adswizz.com"&gt;pcm.adswizz.com&lt;/a&gt; for information about our collection and use of personal data for advertising.&lt;/p&gt;</description>

In this episode, Dr. Spencer Nadolsky and Dr. Karl engage with Dr. Susan Davis, a leading endocrinologist and researcher in testosterone therapy for women. They explore the complexities of sexual dysfunction, the role of testosterone in women's health, and the nuances of diagnosing and treating low sexual desire. The conversation delves into the importance of understanding psychosocial factors, the limitations of current testosterone testing, and the appropriate dosing and administration of testosterone therapy. Dr. Davis emphasizes the need for evidence-based practices and the importance of individualized patient care in managing women's sexual health.

The Truth About Testosterone Therapy in Women (with Dr. Susan Davis)

Show Notes: In this episode of Docs Who Lift, the Nadolsky brothers welcome back Dr. Sean Wharton, clinical trialist and one of the leading researchers behind the next generation of oral GLP-1 medications. Together, they break down:The OASIS-4 trial results on 25mg oral semaglutide and how it stacks up to injectable WegovyHow orforglipron, Eli Lilly’s new small-molecule GLP-1, differs from peptide-based drugsWhy these new therapies could make weight management more accessible and affordableThe fascinating pharmacology behind “snack molecules” and small-molecule receptor agonistsCommon misconceptions about bioavailability, dosing, and side effectsThe potential role of oral GLP-1s for patients with mild obesity or cardiometabolic diseaseWhether you’re a clinician, researcher, or patient curious about the future of obesity medicine, this conversation offers a clear look at how science is shifting toward needle-free solutions. <a href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)01185-6/abstract" target="_blank">Oasis 1 Trial Link</a> <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2500969" target="_blank">Oasis 4 Trial Link</a> <a href="https://www.nejm.org/doi/abs/10.1056/NEJMoa2511774" target="_blank">Attain 1 Trial Link</a> Hosted by Simplecast, an AdsWizz company. See <a href="https://pcm.adswizz.com">pcm.adswizz.com</a> for information about our collection and use of personal data for advertising.

<description>&lt;p&gt;&lt;strong&gt;Show Notes:&lt;/strong&gt;&lt;br /&gt;In this episode of &lt;i&gt;Docs Who Lift&lt;/i&gt;, the Nadolsky brothers welcome back &lt;strong&gt;Dr. Sean Wharton&lt;/strong&gt;, clinical trialist and one of the leading researchers behind the next generation of oral GLP-1 medications. Together, they break down:&lt;/p&gt;&lt;p&gt;The &lt;i&gt;OASIS-4&lt;/i&gt; trial results on &lt;strong&gt;25mg oral semaglutide&lt;/strong&gt; and how it stacks up to injectable Wegovy&lt;/p&gt;&lt;p&gt;How &lt;strong&gt;orforglipron&lt;/strong&gt;, Eli Lilly’s new &lt;i&gt;small-molecule&lt;/i&gt; GLP-1, differs from peptide-based drugs&lt;/p&gt;&lt;p&gt;Why these new therapies could make weight management more accessible and affordable&lt;/p&gt;&lt;p&gt;The fascinating pharmacology behind “snack molecules” and small-molecule receptor agonists&lt;/p&gt;&lt;p&gt;Common misconceptions about bioavailability, dosing, and side effects&lt;/p&gt;&lt;p&gt;The potential role of oral GLP-1s for patients with mild obesity or cardiometabolic disease&lt;/p&gt;&lt;p&gt;Whether you’re a clinician, researcher, or patient curious about the future of obesity medicine, this conversation offers a clear look at how science is shifting toward needle-free solutions.&lt;br /&gt;&lt;br /&gt;&lt;a href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)01185-6/abstract" target="_blank"&gt;Oasis 1 Trial Link&lt;/a&gt;&lt;br /&gt;&lt;br /&gt;&lt;a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2500969" target="_blank"&gt;Oasis 4 Trial Link&lt;/a&gt;&lt;br /&gt;&lt;br /&gt;&lt;a href="https://www.nejm.org/doi/abs/10.1056/NEJMoa2511774" target="_blank"&gt;Attain 1 Trial Link&lt;/a&gt;&lt;/p&gt;&lt;br/&gt; &lt;p&gt;Hosted by Simplecast, an AdsWizz company. See &lt;a href="https://pcm.adswizz.com"&gt;pcm.adswizz.com&lt;/a&gt; for information about our collection and use of personal data for advertising.&lt;/p&gt;</description>

Dr. Spencer and Dr. Karl sit down with Dr. Sean Wharton, lead author on the OASIS-4 and ATTAIN-1 trials, to unpack the groundbreaking data behind the new oral GLP-1 medications. They discuss how oral semaglutide and orforglipron compare to injectables, what makes these molecules unique, and why 2026 could be the year obesity care changes forever.

From Injections to Pills: Breaking Down the New Oral GLP-1 Data

Drs. Spencer and Karl Nadolsky talk about nutrition, medicine, and fitness through the lens of two physicians who lift weights. Both doctors are former NCAA division 1 wrestlers who have gone into medicine. Dr. Spencer Nadolsky is a board certified family physician specialized in obesity medicine and lipidology. Dr. Karl Nadolsky is a board certified endocrinologist also specialized in obesity medicine.

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