AI For Pharma Growth

Digital biomarkers are turning everyday movement into clinically useful data, giving doctors a clearer picture of what’s happening between appointments, and giving pharma new ways to measure drug impact earlier and more precisely. In this episode, Dr Andree Bates interviews Dr Quique Llaudet, CEO and co-founder of Ephion Health, about precision monitoring and how AI-driven mobility analysis is changing both clinical care and drug development.Quique shares his journey from academic research into entrepreneurship, driven by a desire to turn science into real products that help patients. Ephion Health grew out of early work with paediatric hospitals in Barcelona, where sensor technology used in rehabilitation and exoskeleton projects revealed a bigger opportunity: objective, high-sensitivity gait and movement analysis that can detect disease signatures and track progression over time.The conversation breaks down what a digital biomarker actually is: a measurable signal of health captured via connected devices and analysed with digital methods. Ephion’s platform integrates multiple validated, off-the-shelf sensors to capture rich movement data in a short test, replacing blunt measures like the six-minute walk test with something both more sensitive and less stressful for patients. The system then combines key parameters into a single composite score to track progression and treatment response.Quique also tackles the “black box” concern head on. He explains how their models are developed alongside clinicians, with clinical relevance checked throughout, and how doctors can inspect the underlying parameters behind the biomarker score in a dashboard. For rare diseases with limited data, he highlights deep collaboration with clinicians and patient associations, and the use of synthetic data to support modelling and testing.Finally, Quique outlines the economics: reducing specialist assessment time, enabling more frequent remote monitoring, supporting earlier treatment adjustments, and helping pharma generate evidence in real-world settings. The long-term vision is continuous monitoring that helps clinicians act earlier, plus AI-assisted diagnosis and eventually prevention.Topics CoveredWhat digital biomarkers are and how they differ from traditional biomarkersTurning mobility data into clinically meaningful signalsMulti-sensor monitoring: IMUs, pressure insoles, and EMGWhy short tests can beat the six-minute walk testComposite biomarker scoring and tracking treatment responseAI patterns clinicians may sense but cannot quantifyExplainability and building models “hand in hand” with doctorsData challenges in rare disease and the role of patient associationsSynthetic data for modelling and validationEconomic impact: time savings, remote monitoring, and better treatment adjustmentPharma use cases: real-world evidence and earlier efficacy signals in trialsAbout the PodcastAI For Pharma Growth is the podcast from pioneering Pharma Artificial Intelligence entrepreneur Dr Andree Bates, created to help pharma, biotech and healthcare organisations understand how AI-based technologies can save time, grow brands, and improve company results.This show blends deep sector experience with practical conversations that demystify AI for biopharma leaders, from start-up biotech right through to Big Pharma. Each episode features experts building AI-powered tools that are driving real-world results across discovery, R&D, clinical trials, medical affairs, market access, regulatory, insights, sales, marketing, and more.Dr. Andree Bates LinkedIn | Facebook | X

Digital twins have become one of the most promising tools in Alzheimer’s research, but the bigger story is what happens when they scale across disease areas. In this episode, Dr Andree Bates interviews Aaron Smith, Founder and Head of Machine Learning at Unlearn AI, about how “digital twin generators” can transform trial design by modelling realistic patient progression and improving statistical power without compromising the fundamentals of randomised controlled trials.Aaron shares his journey from academic mathematics into computer vision and machine learning, then into biopharma, where Unlearn began by building generative models that learn the joint distribution of clinical variables. In practice, that means the model can take baseline patient measurements and generate likely future progressions that are as indistinguishable from real clinical records as possible.The conversation dives into a key misconception: digital twins are not only about replacing control arms. Aaron explains a regulatory friendly approach where you keep standard trial structure, but add counterfactual information for every patient into the analysis. Unlearn’s best known method, ProCOVA (prognostic covariate adjustment), summarises a predicted control outcome per patient and uses it for covariate adjustment, creating more efficient treatment effect estimates. The headline result is simple: you can increase power, or reduce recruitment burden while maintaining power, potentially speeding time to results.Finally, Aaron explains why scaling across diseases is genuinely hard. Data structures differ wildly by indication, missingness can block transfer learning, and areas like oncology require modelling complex treatment histories. He also highlights that combining sources is not just “more data”, it demands careful harmonisation and context modelling to avoid biased predictions, especially when bringing in real world evidence.Topics CoveredWhat “digital twin generators” are in clinical trialsGenerative modelling of clinical records and disease progressionCounterfactual prediction under standard of careWhy replacing control arms is not the only use caseProCOVA and prognostic covariate adjustmentGetting more statistical power and reducing trial sizeFDA openness to digital twins in trials and what it enablesWhy scaling across disease areas is not just parameter tuningMissing data, confounding context, and data harmonisationCNS versus oncology modelling challengesReal world evidence and how to validate digital twin modelsAbout the PodcastAI For Pharma Growth is the podcast from pioneering Pharma Artificial Intelligence entrepreneur Dr Andree Bates, created to help pharma, biotech and healthcare organisations understand how AI-based technologies can save time, grow brands, and improve company results.This show blends deep sector experience with practical conversations that demystify AI for biopharma leaders, from start-up biotech right through to Big Pharma. Each episode features experts building AI-powered tools that are driving real-world results across discovery, R&D, clinical trials, medical affairs, market access, regulatory, insights, sales, marketing, and more.Dr. Andree Bates LinkedIn | Facebook | X

AI in drug development is moving beyond “failure prevention” into something much bigger: redesigning how we discover, develop, and deliver medicines. In this episode, Dr Andree Bates speaks with Vitalay Fomin of Numenos about biomarker discovery, patient stratification, and why the next breakthroughs come from breaking down data silos across diseases, modalities, and even species.Vitalay shares his background across biotech and pharma, including work in biomarker discovery, translational medicine, and data science, and how frustration with existing approaches led her to build a new architecture for clinical genomic insights. A core theme is that traditional methods often oversimplify biology by forcing outcomes into binary labels and treating each disease area as an isolated box, even when the available data is too limited to answer meaningful questions well.The conversation explores how foundation model approaches can unify clinical, genomic, transcriptomic, proteomic and imaging signals to create a fuller “biological fingerprint” of each patient. Vitalay explains how this can enable earlier insight from single-arm trials by effectively benchmarking against standard-of-care cohorts, helping teams enrich later-stage trials with the right subpopulations sooner, and reducing time and cost.They also discuss the real blockers to adoption: not only scientific conservatism, but commercial uncertainty around how Big Pharma structures deals with tech-bio companies that bring platforms rather than single assets. Vitalay argues that explainability is non-negotiable in this space, because clinicians, scientists, patients, and regulators will not trust black-box predictions.Topics CoveredWhy AI is shifting from failure prevention to pipeline redesignBiomarker discovery beyond binary responder vs non-responder labelsBreaking disease silos to learn across indicationsMultimodal integration: DNA, RNA, protein, imaging, and clinical dataUsing foundation models to bridge trial data and real-world dataPatient stratification and trial enrichment from early studiesReverse translation and identifying unmet need before target huntingExplainability, trust, and regulatory readinessAdoption barriers: culture, champions, and deal structures for tech-bioMisconceptions about AI in drug development and why “press a button” is a mythAbout the PodcastAI For Pharma Growth is the podcast from pioneering Pharma Artificial Intelligence entrepreneur Dr Andree Bates, created to help pharma, biotech and healthcare organisations understand how AI-based technologies can save time, grow brands, and improve company results.This show blends deep sector experience with practical conversations that demystify AI for biopharma leaders, from start-up biotech right through to Big Pharma. Each episode features experts building AI-powered tools that are driving real-world results across discovery, R&D, clinical trials, medical affairs, market access, regulatory, insights, sales, marketing, and more.Dr. Andree Bates LinkedIn | Facebook | X

Enterprise AI is shifting from experiments to infrastructure, and that changes everything. In this episode, Dr Andree Bates interviews Jocelyn Houle, Senior Director of Product Management at Securiti.ai, to explore the future of enterprise AI, agents, automation, and the single biggest blocker to scale: trust.Jocelyn shares what she is seeing across highly regulated industries as organisations move beyond proof of concept into production. She explains why the agent era raises the stakes: when you add LLMs into workflows, systems become non-deterministic and harder to trace end to end. In her words, once the data goes in, you cannot easily untangle it, so organisations need stronger controls around permissions, auditing, and policy enforcement.A major theme is that data foundations matter more than ever. Jocelyn warns that agents will not magically repair messy data, they will expose weak data quality immediately. From there, she outlines how trust can be won or lost at the prompt layer, both outbound (what the model says to customers) and inbound (what users share with the organisation). She also discusses “toxic combinations”, where overlapping access can accidentally leak sensitive information, plus the growing need for prompt screening and tracking to reduce risk.The conversation also digs into explainability and auditability, with Jocelyn being refreshingly honest that the perfect solution is not here yet. Instead, enterprises are using practical approaches like benchmarking releases side by side, cataloguing AI agents in use, and building governance that is starting to look more like modern cybersecurity: baked in from the start, not added as an afterthought.Jocelyn closes with clear advice for leaders: start “left” with raw data controls, build a truly cross-functional team, and begin setting up auditability even with imperfect tools, because regulators are catching up and they will expect responsible behaviour.Topics CoveredWhere enterprise AI adoption really stands todayWhat makes AI agents different from traditional automationNon-determinism, traceability, and why permissions matterData mapping, policy controls, and reducing sensitive data leakagePrompt security: outbound and inbound trust risks“Toxic combinations” and exposure through agent workflowsExplainability, benchmarking, and parallel release testingAI governance becoming as essential as cybersecurityTop 3 pieces of advice for CTOs starting their AI journeyWhy enterprise AI will become so embedded we stop talking about itAI For Pharma Growth is the podcast from pioneering Pharma Artificial Intelligence entrepreneur Dr Andree Bates, created to help pharma, biotech and healthcare organisations understand how AI-based technologies can save time, grow brands, and improve company results.This show blends deep sector experience with practical conversations that demystify AI for biopharma leaders, from start-up biotech right through to Big Pharma. Each episode features experts building AI-powered tools that are driving real-world results across discovery, R&D, clinical trials, medical affairs, market access, regulatory, insights, sales, marketing, and more.Dr. Andree Bates LinkedIn | Facebook | XAbout the Podcast

Clinical trials are a massive industry with brutal economics, long timelines, and failure rates that would be unacceptable in almost any other sector. In this episode, Dr Andree Bates is joined by Dr Joseph Geraci of NetraMark to break down why trials fail so often, how patient heterogeneity drives cost and uncertainty, and where AI can realistically shift the economics.Joseph shares his unusual path from mathematics and mathematical physics into oncology and medical science, including a decision to move into hospital research rather than follow a more traditional academic route. That shift shaped his focus: not just discovering more molecules, but understanding why the same drug can work brilliantly for some patients and fail for others.A central theme is that clinical trials are not “one disease, one patient type”. In many areas, disease definitions are too broad for trial design, making trials feel like trying to hit multiple dartboards with one dart. Joseph explains how NetraMark’s approach aims to identify meaningful subpopulations inside small datasets, finding the “pocket” where a drug’s true advantage shows up, without discarding patients as outliers.The conversation also touches on regulators, including growing interest in innovation pathways, but also the fear pharma teams have about changing protocols and risking setbacks. Joseph argues that AI’s biggest economic value in trials is speed, using better insight from limited trial data to guide enrichment strategies, smarter substudy decisions, and faster iteration, especially in oncology and rare disease where time is everything.Topics CoveredWhy clinical trial economics are becoming unsustainablePatient heterogeneity and why disease definitions break trialsFinding “pockets” of responders within small datasetsTrial enrichment and substudies that reveal a drug’s advantageWhy pharma adoption can be slow, even when failures are constantRegulatory interest, guidelines, and sponsor risk aversionLarge language models vs mathematically augmented AI approachesSpeed as the biggest economic lever in trialsPractical examples across depression, schizophrenia, oncology, and beyondWhat clinical trials could look like in five years with AI-driven insightThis show blends deep sector experience with practical conversations that demystify AI for biopharma leaders, from start-up biotech right through to Big Pharma. Each episode features experts building AI-powered tools that are driving real-world results across discovery, R&D, clinical trials, medical affairs, market access, regulatory, insights, sales, marketing, and more. Dr. Andree Bates LinkedIn | Facebook | X