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The Dr. Gabrielle Lyon Show
The Dr. Gabrielle Lyon Show

The Dr. Gabrielle Lyon Show

Dr. Gabrielle Lyon

Overview
Episodes

Details

The Dr. Gabrielle Lyon Show promotes a healthy world, and in order to have a healthy world, we must have transparent conversations. This show is dedicated to such conversations as the listener; your education, understanding, strength, and health are the primary focus. The goal of this show is to provide you with a framework for navigating the health and wellness space and, most importantly, being the champion of your own life. Guests include highly trustworthy professionals that bring both the art and science of wellness aspects that are both physical and mental. Dr. Gabrielle Lyon is a Washington University fellowship-trained physician who serves the innovators, mavericks, and leaders in their fields, as well as working closely with the Special Operations Military. She is the founder of the Institute of Muscle-Centric Medicine® and serves patients worldwide.

Recent Episodes

Comfort is Destroying Your Health: Why Stress is Not the Enemy | Jeff Krasno
MAR 25, 2025
Comfort is Destroying Your Health: Why Stress is Not the Enemy | Jeff Krasno

Jeff Krasno’s personal health transformation—reversing diabetes, shedding 60 pounds, and reclaiming his health at age 50—is a masterclass in what he calls “good stress.” In this episode, we dive into the simple but powerful idea that discomfort might just be the medicine we all need. Jeff, the founder of Commune and host of the Commune podcast, shares how fasting, cold exposure, resistance training, and attention to modern habits helped him regain his energy, build muscle, and thrive.

Together, we discuss how metabolic dysfunction has become the norm, how adaptive stress responses can be harnessed to reverse chronic illness, and why building muscle is not only the antidote to obesity but also a critical factor in longevity. If you’re interested in reclaiming your vitality and learning how to work with—not against—your biology, this episode will speak to you.

We cover:

  • Jeff’s story of personal health transformation at midlife
  • What “good stress” is and how to harness it to improve health
  • Why chronic ease leads to chronic disease
  • Cold therapy, fasting, and training as adaptive stressors
  • The importance of resistance training for blood sugar control
  • How metabolic dysfunction hides in plain sight
  • Practical tips to increase non-exercise activity thermogenesis (NEAT)
  • Building muscle as the path to longevity and disease prevention

Who is Jeff Krasno?

Jeff Krasno is the co-founder and CEO of Commune, a masterclass platform for personal and societal well-being. He hosts the Commune podcast, where he’s interviewed luminaries like Deepak Chopra, Gabor Maté, and Matthew McConaughey. Jeff also writes a weekly personal essay called “Commusings,” delivered to over a million subscribers every Sunday. His new project, Good Stress, is an online course, upcoming book, and developing TV series, built on the wellness strategies that helped him reclaim his health after a diabetes diagnosis. He is also the co-creator of the global wellness event series Wanderlust and was selected for Oprah’s SuperSoul100 in 2016.

This episode is brought to you by:


Find Jeff Krasno at:


Find me at:


Timestamps:

00:00 – Intro & Forever Strong Summit Announcement

02:07 – Meet Jeff Krasno

03:26 – Chronic ease and the rise of chronic disease

05:55 – Adaptive stress responses: why we evolved to need discomfort

07:19 – The comfort traps of modern life

08:24 – Sedentary lifestyles and metabolic consequences

10:10 – Stress, cortisol, and modern triggers

14:05 – What is “good stress”?

15:00 – Jeff’s health breakdown and the first signs of metabolic dysfunction

17:32 – Using a CGM to detect prediabetes

19:25 – The shocking blood sugar results

20:31 – Spiritual and cultural influences on Jeff’s diet

23:37 – How Jeff’s body composition changed

24:44 – The shift to a ketotarian diet

30:09 – Fasting, ketones, and metabolic flexibility

32:55 – Intermittent fasting and circadian biology

35:14 – The combination that moved the needle: fasting + cold exposure

41:21 – Cold plunges and thermogenesis

44:39 – Why cold stress melts fat

48:06 – The motivation behind embracing discomfort

52:00 – Building muscle: the final frontier of Jeff’s transformation

53:27 – Resistance training for metabolic health

54:45 – The trap of “chronic cardio”

57:14 – The difference between losing fat and building muscle

59:23 – How Jeff learned the science through self-experimentation

1:01:01 – From bodyweight training to pull-ups and gym sessions

1:04:28 – Why resistance training finally clicked for Jeff

1:07:47 – Jeff’s recommendations: move more, lift often, live intentionally

1:11:45 – NEAT: the underrated tool for metabolic health

1:12:56 – Jeff’s final thoughts: redefining ease and fulfillment

Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

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106 MIN
Steroids & Testosterone: The Science Behind Anabolic Therapies | Nelson Vergel
MAR 18, 2025
Steroids & Testosterone: The Science Behind Anabolic Therapies | Nelson Vergel

Nelson Vergel’s story is one of resilience, perseverance, and an unrelenting drive to defy the odds. In the mid-1980s, he was handed what many would have considered a death sentence—an HIV diagnosis at a time when there were no effective treatments, no clear answers, and little hope. Today, he is a beacon of knowledge and empowerment for those seeking to take control of their health, whether they are dealing with wasting conditions, hormone deficiencies, or simply aiming for peak performance. Nelson has spent decades researching and advocating for hormone health, muscle preservation, and medical autonomy, particularly for those facing wasting conditions like HIV and cancer. His work has helped shape the conversation around androgen therapies, the role of anabolic agents in aging, and the intersection of GLP-1 medications with muscle loss.

We cover:

  • Nelson's personal journey from an HIV diagnosis to hormone optimization
  • The history, misconceptions and stigma surrounding anabolic agents
  • The differences between various anabolic agents and how they work
  • The impact of GLP-1 medications on lean mass and how to mitigate muscle loss
  • Best practices for hormone monitoring and optimization

If you want to hear an inspiring story of overcoming the odds to take control of your own health or you’re curious about anabolic therapies and longevity, you can’t miss this one.   

Who is Nelson Vergel?

Nelson Vergel is a chemical engineer, author, and health advocate who has made significant contributions to men's health and hormone optimization. His most recent book, Beyond Testosterone, provides a detailed color guide to educate clinicians and patients about the latest advances in the use of testosterone, anabolics, and other therapies to maximize health and productivity.

This episode is brought to you by:


Find Nelson Vergel at:


Find me at:


Timestamps:

00:00 - Intro & Forever Strong Summit Announcement

02:21 - Meet Nelson Vergel

04:34 - Nelson’s journey from HIV diagnosis to hormone health advocacy

08:12 - The role of testosterone and anabolic agents in muscle preservation

14:42 - The stigma and misconceptions surrounding anabolic therapies

18:01 - How nandrolone and oxandrolone compare to testosterone

24:04 - The intersection of GLP-1 medications and muscle loss

30:17 - The importance of resistance exercise alongside hormone therapy

35:07 - Why muscle loss is a serious public health issue

41:55 - How to safely monitor hormones and optimize health

48:00 - The role of compounding pharmacies in hormone replacement therapy

52:47 - What the future holds for anabolic therapies and longevity

1:02:00 - Why personalized medicine is key to effective hormone management

1:09:14 - Final thoughts & where to find Nelson Vergel

Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

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95 MIN
The Truth About Calories and Weight Loss | Dr. James Hill
MAR 11, 2025
The Truth About Calories and Weight Loss | Dr. James Hill

Dr. James Hill—a expert on obesity, metabolism, and long-term weight management—joins me this week to unpack the biggest challenges in sustainable fat loss. Dr. Hill has spent decades researching weight control and the factors that determine whether people can keep weight off long-term. We discuss the science behind energy balance, metabolic flexibility, and why long-term weight loss is about more than just diet and exercise. He shares insights from his groundbreaking work with the National Weight Control Registry, the role of GLP-1 medications, and why physical activity is the key to preventing weight regain.

We cover:

  • The critical differences between weight loss and weight maintenance
  • Why physical activity is perhaps more important for keeping weight off than losing it
  • The National Weight Control Registry: lessons from long-term weight loss success stories
  • How metabolism, muscle mass, and energy expenditure affect weight regain
  • The role of protein and resistance training in preserving lean mass
  • The impact of GLP-1 medications on weight loss and why most people regain weight after stopping them
  • The psychology of weight maintenance: mindset, self-monitoring, and behavior change

If you’ve ever struggled to keep weight off, or you’re interested in the latest research on metabolic health and sustainable weight management, this episode is a must-listen.

Who is Dr. James Hill?

Dr. James Hill is an internationally recognized expert on obesity, metabolism, and weight management. He is the co-founder of the National Weight Control Registry, the largest ongoing study tracking individuals who have successfully lost weight and kept it off long-term. Dr. Hill has published over 400 scientific articles and has led pioneering research on energy balance, metabolic flexibility, and the role of physical activity in weight maintenance. He is a professor at the University of Alabama at Birmingham and has served as the President of The Obesity Society. His work has been instrumental in shaping modern obesity treatment and prevention strategies.

This episode is brought to you by:


Find Dr. James Hill at:


Find me at:   

Instagram: @drgabriellelyon

TikTok: @drgabriellelyon

Facebook: facebook.com/doctorgabriellelyon

YouTube: youtube.com/@DrGabrielleLyon

X: x.com/drgabriellelyon

Apply to become a patient - https://drgabriellelyon.com/new-patient-inquiry/

Join my weekly newsletter - https://institute-for-muscle-centric-medicine.ck.page

Get my book - https://drgabriellelyon.com/forever-strong/

Forever Strong Summit 2025 - Grab your ticket NOW before we sell out! https://drgabriellelyon.com/forever-strong-summit-2025/

Timestamps:

00:00 - Intro & Forever Strong Summit Announcement

02:21 - Meet Dr. James Hill

04:34 - Why obesity wasn’t always a major concern

08:12 - The truth about energy balance and weight loss

14:42 - Weight loss vs. weight maintenance: why they require different strategies

18:01 - Why food restriction works for weight loss but fails for maintenance

24:04 - The role of dietary protein and resistance training in weight loss

30:17 - How small changes in energy balance lead to big results

35:07 - Why 150 minutes of exercise per week isn’t enough to maintain weight loss

41:55 - Why most people regain weight after stopping GLP-1 medications

48:00 - How metabolic flexibility influences weight control

52:47 - The importance of tracking body composition over time

1:02:00 - Why exercising your metabolism is key to long-term success

1:09:14 - The underestimated role of mindset in weight management

1:18:27 - The future of obesity treatment: personalized approaches


Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

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100 MIN
The Science of Optimizing Your Testosterone | Abraham Morgentaler, MD
MAR 4, 2025
The Science of Optimizing Your Testosterone | Abraham Morgentaler, MD

In this episode, Dr. Abraham Morgentaler—an expert in urology and hormone health—helps unpack the biggest myths and misconceptions surrounding testosterone therapy for both men and women. He shares his pioneering research on testosterone replacement therapy, challenging outdated fears about its link to prostate cancer and highlighting the latest findings on how hormone therapy can impact overall health, libido, and longevity. The conversation explores the controversial history of testosterone in medicine, the common mismanagement of hormone deficiencies, and why free testosterone may be one of the most important markers for health.

We cover:

  • The truth behind the testosterone-prostate cancer debate
  • How testosterone deficiency is linked to obesity, cardiovascular disease, and dementia
  • The stigma around testosterone therapy and why so many people remain untreated
  • The effects of testosterone therapy on fertility, muscle mass, and mental well-being
  • The role of testosterone in women's health and aging
  • The latest advancements in testosterone treatments and how they compare

Whether you’re considering testosterone therapy, navigating hormone-related issues, or just interested in optimizing your health, this episode offers critical insights that could reshape your understanding of testosterone and its role in overall well-being.

Who is Abraham Morgentaler?

Dr. Abraham Morgentaler is a leading expert in men’s health and a pioneer in the treatment of testosterone deficiency. His research helped overturn the long-held belief that testosterone therapy increases prostate cancer risk, and he has published over 200 scientific articles on testosterone, prostate cancer, and male sexual health. A Harvard-trained urologist, he is currently the Blavatnik Faculty Fellow in Health and Longevity at Harvard Medical School. Dr. Morgentaler is also the founder of Men’s Health Boston and co-founder of the Androgen Society, and he continues to educate clinicians worldwide through his virtual fellowship and best-selling books on men's health.

This episode is brought to you by:


Find Dr. Morgentaler at:


Find me at:


Timestamps:

00:00 - Intro & Forever Strong Summit Announcement

02:30 - Meet Dr. Abraham Morgentaler

04:40 - Debunking the Testosterone-Prostate Cancer Myth

11:38 - How a Flawed Study Shaped Decades of Misinformation

19:22 - Testosterone’s Impact on Mood, Energy, and Quality of Life

25:33 - The Truth About Testosterone & Cardiovascular Risks

30:17 - How Mainstream Medicine Got Testosterone Completely Wrong

44:26 - Why Men Are Hesitant About Testosterone Therapy

50:06 - Defining Low Testosterone: What Numbers Actually Matter?

59:54 - Saturation Model: Why More Testosterone Doesn’t Always Equal More Benefit

1:06:19 - Free vs. Total Testosterone—What’s Really Important?

1:19:14 - Why Testosterone Therapy for Women is Still Controversial

1:37:10 - FDA Regulations & the Future of Testosterone Therapy

1:51:06 - Why Men Have Been Misunderstood for Decades

Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

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114 MIN
The Truth About Nutrition: How You Can Take a Science-Based Approach | Bradley Johnston PhD
FEB 25, 2025
The Truth About Nutrition: How You Can Take a Science-Based Approach | Bradley Johnston PhD

Misinformation in nutrition is rampant. From demonizing red meat to hyping plant-based diets, conflicting advice has left many people confused about what’s truly evidence-based. In this episode, I am joined by Dr. Bradley Johnston, an expert in evidence-based nutrition and public health policies, to separate fact from fiction. With nearly 200 peer-reviewed publications, Dr. Johnston has challenged conventional wisdom—including recommendations from major organizations like the World Health Organization. He shares how evidence-based practices should guide our dietary choices, the importance of systematic reviews and meta-analyses, and how cognitive biases influence the research we trust.

Key Points:

  • How evidence-based guidelines are formed—and why they sometimes change
  • The three pillars of evidence-based practice and why patient values matter
  • Why most nutrition studies aren’t as strong as we think—and how to critically evaluate them
  • What the best available research actually says about dietary patterns for longevity
  • The role of AI in research and whether it’s a help or hindrance to scientific rigor

If you’ve ever questioned dietary guidelines, nutrition headlines, or conflicting health advice, this episode is a must-listen. Get ready to rethink everything you thought you knew about nutrition.

Who is Dr. Bradley Johnston?

Dr. Bradley Johnston is an Associate Professor at Texas A&M University, specializing in evidence-based nutrition, and the methodology of patient-reported outcomes, randomized clinical trials, systematic reviews, and clinical and public health practice guidelines.

With a PhD in experimental medicine from the University of Alberta and post-doctoral training in evidence-based practice, epidemiology and biostatistics from Oxford and McMaster University, his research focuses on advancing human health research methodology to improve clinical and dietary practice recommendations and public health policies. He co-leads EvidenceBasedNutrition.org and NutriRECS, develops nutrition education resources (e.g. Nutrition Users’ Guides), and currently serves as Co-Chair of the Canadian Pediatric Obesity Management Guidelines, ensuring clinical and public health guidelines are backed and transparently supported by the best available evidence, including end user values and preferences, absolute estimates of effect and the certainty of evidence for estimates of effect. His overall aim is to empower patients, clients and members of the public to make fully-informed health care decisions based on the central tenets of evidence-based practice and policy.

This episode is brought to you by:


Find Dr. Bradley Johnston at:


Find Me At:

  • Instagram: @drgabriellelyon
  • Tik Tok: @drgabriellelyon
  • Facebook: facebook.com/doctorgabriellelyon
  • YouTube: youtube.com/@DrGabrielleLyon
  • Apply to become a patient - https://drgabriellelyon.com/new-patient-inquiry/
  • Join my weekly newsletter - https://institute-for-muscle-centric-medicine.ck.page
  • Get my book - https://drgabriellelyon.com/forever-strong/  

Timestamps:

00:00 - The problem with nutrition misinformation

02:23 - Dr. Bradley Johnston’s background in evidence-based research

07:23 - The history of evidence-based practices in nutrition

12:14 - Why expert biases impact research findings

19:40 - How systematic reviews and meta-analyses work

25:41 - Are we even asking the right nutrition questions?

35:00 - How much evidence is actually needed to make a recommendation?

45:48 - The GRADE approach for evaluating certainty in scientific findings

58:57 - Why animal studies don’t always translate to human health

1:08:23 - Strong vs. conditional recommendations—what do they mean?

1:27:56 - Will AI improve or worsen research quality?

Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

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90 MIN