The Dr. Gabrielle Lyon Show

We are living through one of the most significant shifts in medicine in generations, and most people don’t fully understand what it means. Dr. Christle Guevarra joins me to zoom out on the entire GLP-1 landscape; from the drug’s origins as a modest diabetes treatment in 2005 to today’s third-generation medications still moving through clinical trials, and what all of it means for the future of obesity, performance, and longevity.🙌Thank you to our sponsors:🌍 Cozy Earth - Go to https://bit.ly/4teXQhz for up to 20% off!🤍 Timeline - Get 20% off your Mitopure order at https://www.timeline.com/lyon🚲 Carol Bike - Visit https://bit.ly/4tg4cxa and use code LYON for $100 off your CAROL BikeExplore More from Dr. Gabrielle Lyon:Premium Podcast Subscription: Ad-free episodes, key takeaway summaries, exclusive Q&A, and behind-the-scenes content https://foreverstrong.supercast.comWeekly newsletter: Recipes, podcast updates, and practical weekly insights https://drgabriellelyon.com/sign-up/Apply to become a patient: Personalized care with Dr. Lyon’s clinical team https://drgabriellelyon.com/new-patient-inquiry/Connect with Dr. Christle GuevarraYouTube: https://bit.ly/4vDMVQaInstagram: https://bit.ly/4mxnfAcGet Dr. Christle Guevarra’s book, “Bodybuilding Anatomy”: https://bit.ly/3ODIDYd📺Watch the “Dr. Gabrielle Lyon Show” every Tuesday at 9AM EST:YouTube: https://bit.ly/4boCFC3Spotify: https://bit.ly/4cWTbLG📱Connect with Dr. Gabrielle Lyon:Instagram: https://bit.ly/4uk9adcTikTok: https://bit.ly/3OFK3kJX.com: https://bit.ly/4l3YlaXFacebook: https://bit.ly/3MBrJso⏰Timestamps:00:00 Intro of Show06:48 Changes in the Fat Loss Landscape06:54 Engagement in Competitive Powerlifting11:29 Perspectives on GLP-1 Medication26:10 Perimenopause Journey27:13 Topamax28:03 Urosepsis30:23 Weight Loss Programming31:43 Patients' Decision to Take GLP-137:44 Risks and Effects on Taking GLP-138:10 Pancreatitis41:40 Fen-Phen (Fenfluramine/phentermine) / Ephedra45:59 Who Should Not Take GLP-1?49:24 Proper Nutrition to Support Taking GLP-152:14 Recommendation for the New Dietary Guidelines59:01 Residency and Sports Medicine Fellowship1:02:38 Are Athletes Recommended to Take GLP-1?1:08:49 Lack of Randomized, Controlled Trials for Peptides1:10:38 Key Take-away's from Dr. Christle1:13:24 Should Women Weigh Themselves?1:21:02 Should Women Lift Weights?1:21:55 What's Next for Dr. Christle?‼️Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.This episode includes paid sponsorships.

The moment you decide to show up publicly, you open the door to opinions from people who would never say those things to your face. Dominique Sachse, journalist, author, and content creator who has lived her life on camera for over three decades, gets honest about what it costs to put yourself out there, why online cruelty is a psychology problem more than a content problem, and how “Teflon Dom” developed the thick skin to let none of it redirect her.Want ad-free episodes? Subscribe to Forever Strong Insider: https://bit.ly/4u5VSReGet Dominique Sachse’s book, “Life Makeover: Embrace the Bold, Beautiful, and Blessed You”: https://bit.ly/4meV7lkListen to "Over 50 & Flourishing" on all your favorite platforms!YouTube: https://bit.ly/4meCeyYSpotify: https://bit.ly/4cwdvTsApple Podcasts: https://bit.ly/4bVin4s📱Connect with Dominique Sachse:Website: https://bit.ly/41VFUfCYouTube: https://bit.ly/41YNk1CInstagram: https://bit.ly/3OgHXHUFacebook: https://bit.ly/41G41iBTikTok: https://bit.ly/4sXBbWBLinkedIn: https://bit.ly/3PYRvIf🙌Thank you to our sponsors:💪BodyHealth - Use the code LYON 20 to get 20% off your first order https://bit.ly/4mhPTVS🍳Our Place - Our Place - Visit https://bit.ly/4c8OrAB and use code DRLYON for 10% off sitewide😁Branch Basics - Get 15% off the Premium Starter Kit at https://bit.ly/48xF5NK with the code DRLYON❤️Amp - Visit https://bit.ly/4cwLoDJ to get your AI-powered at-home gym for smarter, personalized training📺Watch the “Dr. Gabrielle Lyon Show” every Tuesday at 9AM EST:YouTube: https://bit.ly/4boCFC3Spotify: https://bit.ly/4cWTbLG📱Connect with Dr. Gabrielle Lyon:Instagram: https://bit.ly/4uk9adcTikTok: https://bit.ly/3OFK3kJX.com: https://bit.ly/4l3YlaXFacebook: https://bit.ly/3MBrJsoLinkedIn: https://bit.ly/3N1nrdLWebsite: https://bit.ly/3NdV2kTBooks: https://bit.ly/4r6ugZKNewsletter: https://bit.ly/402QCAj⏰Timestamps:00:00 ​Intro of Show02:10 Dominique’s Mission05:13 Women’s Reinvention with Aging12:07 Handling People’s Opinions in the Media18:03 Why Dominique Wrote “Life Makeover”26:08 Activating One’s Faith through Life’s Challenges29:16 Decision to Leave the News Business34:12 Traditional Media Transitioning to Online Media37:09 How to Curate Information38:42 Effectively Communicating with Journalism and Research Skills43:17 Managing Conflicts On-and-Off Air45:28 The Aging Process49:53 Personal Training with Body Builders52:33 Changes in Training and Nutrition54:49 Importance of Discipline1:00:28 How Dominique Makes Decisions1:04:03 Dominique’s Goal and Message1:08:46 Midlife Wellness Protocols1:14:29 What’s Next for Dominique?‼️Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.This episode includes paid sponsorships.

Only nine scientists were asked to advise on the 2025 Dietary Guidelines for Americans, and Dr. Tom Brenna was one of them. In this conversation, he pulls back the curtain on how dietary guidelines are actually made, why the process has never been the same twice, and what it was like to watch a decades-old saturated fat recommendation get carried forward despite a lack of evidence supporting it at the level of total mortality. This is the dietary guidelines conversation the internet has been missing: straight from someone who was actually in the room.Want ad-free episodes? Subscribe to Forever Strong Insider: https://bit.ly/4u5VSRe📱Connect with Dr. Tom BrennaWebsite: https://bit.ly/3O3cNUvInstagram: https://bit.ly/4s7UF9NLinkedIn: https://bit.ly/4shYfylReferences:https://nutrition.org/american-society-for-nutrition-calls-for-strong-science-in-national-nutrition-guidance/https://ajcn.nutrition.org/article/S0002-9165(24)00527-6/fulltext🙌Thank you to our sponsors:😁Manukora - Save 31% plus $25 worth of free gifts. https://bit.ly/4sglER1💪Timeline - Get 20% off your Mitopure order at https://bit.ly/3NkQAB5❤️Bon Charge - Save 15% at https://bit.ly/4cDyV1G with code DRLYON📺Watch the “Dr. Gabrielle Lyon Show” every Tuesday at 9AM EST:YouTube: https://bit.ly/4boCFC3Spotify: https://bit.ly/4cWTbLG📱Connect with Dr. Gabrielle Lyon:Instagram: https://bit.ly/4uk9adcTikTok: https://bit.ly/3OFK3kJX: https://bit.ly/4l3YlaXFacebook: https://bit.ly/3MBrJsoLinkedIn: https://bit.ly/3N1nrdLWebsite: https://bit.ly/3NdV2kTBooks: https://bit.ly/4r6ugZKNewsletter: https://bit.ly/402QCAj⏰Timestamps:00:00 ​Intro of Show00:14 Dr. Tom Brenna’s Background05:19 Working with IBM08:46 Family Life10:38 2015 vs. 2025 Dietary Guidelines for Americans28:06 American Society for Nutrition: Behind-the-Scenes of Dietary Guidelines32:10 History of Saturated Fat42:17 Different Types of Fat45:23 How Are People Eating during World War II51:09 The Whole Milk for Healthy Kids Act of 202553:58 What is Saturated Fat?57:57 Link between Saturated Fat and Cardiovascular Diseases1:05:53 Saturated Fat vs. Total Mortality1:13:13 Best Studies on Saturated Fat1:14:42 Reduction of Saturated Fat = Lowered LDL Cholesterol1:22:35 Pregnancy and Fish Consumption Myths1:37:55 Recommended Nutrition1:39:59 Different Types of Oil and Effects on Health1:42:04 Omega 3’s and 6’s Recommendation1:50:02 Omega 3 Fatty Acids and ADHD1:50:54 What’s Next: Precision Nutrition and Genetics‼️Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.This episode includes paid sponsorships.

In a world flooded with conflicting health advice, how do you actually figure out what’s true? Dr. David Allison, one of the most rigorous scientific minds in obesity and nutrition research, shared the exact framework he uses to evaluate evidence, from peer-reviewed trials to podcast recommendations to AI-generated summaries. He explains the difference between trusting science as a process and trusting individual studies, why most nutrition epidemiology functions more like advertising than research, and how ordinary people can build a reliable filter for health claims without a PhD.Want ad-free episodes? Subscribe to Forever Strong Insider: https://bit.ly/4u5VSRe📱Connect with Dr. David AllisonLinkedIn: https://bit.ly/3O6quC2🙌Thank you to our sponsors:💪OneSkin - Get 15% off at https://bit.ly/3Q8vSFi with code DRLYON🍳Timeline - Get 20% off a Mitopure subscription at https://bit.ly/4uYiu6C😁Carol Bike - Visit https://bit.ly/4v7XsTp and use code LYON for $100 off your CAROL Bike💪🏼 AMP - Visit https://amp.ai/ to get your AI-powered at-home gym for smarter, personalized training.📺Watch the “Dr. Gabrielle Lyon Show” every Tuesday at 9AM EST:YouTube: https://bit.ly/4boCFC3Spotify: https://bit.ly/4cWTbLG📱Connect with Dr. Gabrielle Lyon:Instagram: https://bit.ly/4uk9adcTikTok: https://bit.ly/3OFK3kJX.com: https://bit.ly/4l3YlaXFacebook: https://bit.ly/3MBrJsoLinkedIn: https://bit.ly/3N1nrdLWebsite: https://bit.ly/3NdV2kTBooks: https://bit.ly/4r6ugZKNewsletter: https://bit.ly/402QCAj⏰Timestamps:00:00 ​Intro of Show03:55 Dr. David Allison’s Background09:50 Principles vs. Scientific Data14:48 What is Doubly-Labeled Water?16:42 Misconceptions on Diet21:08 Concept of Human Discomfort24:18 Childhood Obesity28:49 Research: What Really is the Purpose?31:14 Can We Trust Science?40:54 INSERT LINK: NEWSLETTER ON OBESITY AND ENERGETICS40:54 Obesity: Causes and Treatments50:29 Different Outcomes from Weight Loss Drugs57:21 Safety is a Social Judgment1:00:18 Making Decisions in a Noisy Landscape1:08:29 Podcasts as a Good Source of Information1:16:09 Stance on Ultra-Processed Foods and Seed Oils1:22:50 Dr. David’s New Projects1:29:40 How to Make Good Decisions‼️Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.This episode includes paid sponsorships.

Up to 70% of dementia may be preventable, so why aren’t more people talking about what actually drives cognitive decline? In this episode, I’m with Dr. Tommy Wood, neuroscientist and author of “The Stimulated Mind,” to explore the lifestyle levers that protect your brain across a lifetime. Learn how white matter hyperintensities develop and whether they can reverse, what MCTs and ketones actually do for a glucose-starved brain, and why social connection may be the most underrated variable in cognitive aging. What is the one change you could make today that would most protect your brain tomorrow?Want ad-free episodes? Subscribe to Forever Strong Insider: https://bit.ly/4u5VSReGet Dr. Tommy Wood’s book, “The Stimulated Mind”: https://bit.ly/4bYIUxEListen to "Better Brain Fitness" on all your favorite platforms!YouTube: https://bit.ly/4bGqxMNSpotify: https://bit.ly/4c0OGPjApple Podcasts: https://bit.ly/3NL7toq📱Connect with Dr. Tommy Wood:Website: https://bit.ly/3NIV4RXYouTube: https://bit.ly/3NVWWHaInstagram:https://bit.ly/40L6w2zX: https://bit.ly/3NTpFMQLinkedIn: https://bit.ly/4c0iETw🙌Thank you to our sponsors:💪Timeline - Get 20% off a Mitopure subscription at https://bit.ly/3NkQAB5🍳Four Sigmatic - Go to https://bit.ly/4spO5wn for a free bag of their dark roast ground coffee (just pay for shipping & handling).😁Branch Basics - Get 15% off the Premium Starter Kit at BranchBasics.com with the code DRLYON.📺Watch the “Dr. Gabrielle Lyon Show” every Tuesday at 9AM EST:YouTube: https://bit.ly/4boCFC3Spotify: https://bit.ly/4cWTbLG📱Connect with Dr. Gabrielle Lyon:Instagram: https://bit.ly/4uk9adcTikTok: https://bit.ly/3OFK3kJX.com: https://bit.ly/4l3YlaXFacebook: https://bit.ly/3MBrJsoLinkedIn: https://bit.ly/3N1nrdLWebsite: https://bit.ly/3NdV2kTBooks: https://bit.ly/4r6ugZKNewsletter: https://bit.ly/402QCAj⏰Timestamps:00:00 ​Intro of Show01:52 Elite Athlete’s Brain and Emotional Regulation06:51 How to Regulate Emotions11:30 Mindset Impacting Hormonal Responses15:39 Future-Proofing the Brain19:42 Brain Development vs. Shrinkage26:11 Dementia Types, Causes, and Prevention39:29 Social Isolation Influencing Cognitive Function50:00 Social Stress’ Drivers52:34 Non-Negotiable’s to Avoid Dementia Risks57:42 Seafood Consumption Beneficial for Brain Function1:03:35 Alcohol and Sleep Impacting the Brain1:10:16 Is Brain Function Recovery Possible?1:18:43 Use of Ketones and Glucose for Cognitive Recovery1:23:09 Power of Mindfulness1:27:06 Get Dr. Wood’s Book‼️Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.This episode includes paid sponsorships.