The Dr. Gabrielle Lyon Show
The Dr. Gabrielle Lyon Show

The Dr. Gabrielle Lyon Show

Dr. Gabrielle Lyon

Overview
Episodes

Details

The Dr. Gabrielle Lyon Show promotes a healthy world, and in order to have a healthy world, we must have transparent conversations. This show is dedicated to such conversations as the listener; your education, understanding, strength, and health are the primary focus. The goal of this show is to provide you with a framework for navigating the health and wellness space and, most importantly, being the champion of your own life. Guests include highly trustworthy professionals that bring both the art and science of wellness aspects that are both physical and mental. Dr. Gabrielle Lyon is a Washington University fellowship-trained physician who serves the innovators, mavericks, and leaders in their fields, as well as working closely with the Special Operations Military. She is the founder of the Institute of Muscle-Centric Medicine® and serves patients worldwide.

Recent Episodes

Protein First: How the New Dietary Guidelines Shift Nutrition
FEB 3, 2026
Protein First: How the New Dietary Guidelines Shift Nutrition
Want ad-free episodes? Subscribe to Forever Strong Insider: https://foreverstrong.supercast.comIn this episode, Dr. Gabrielle Lyon sits down with Dr. Donald Layman, one of the world’s leading protein researchers and a key contributor to the newly released U.S. Dietary Guidelines. They explore why the old food pyramid failed, how nutrition science became driven by ideology instead of evidence, and what the updated guidelines finally get right about protein, fats, and carbohydrates. Dr. Layman explains why the long-standing protein recommendation of 0.8 g/kg was never intended for optimal health and how higher protein intake supports body composition, metabolic health, and nutrient adequacy.The conversation also dives into controversial topics including saturated fat, carbohydrate tolerance, animal versus plant protein, and the limitations of epidemiology in nutrition research. Gabrielle and Dr. Layman discuss how dietary guidelines shape school lunches, hospitals, and public institutions, and why a protein-first framework empowers individuals to make better nutrition decisions, especially as we age. This episode offers a clear, science-backed roadmap for understanding modern nutrition — cutting through misinformation and outdated dogma to focus on strength, longevity, and real-world application.Thank you to our sponsors: Timeline - Get 35% off a Mitopure subscription at https://www.timeline.com/drlyonBon Charge - Save 15% at https://boncharge.com/ with code DRLYONManukora - Go to https://www.MANUKORA.com/DRLYON to save 31% plus $25 worth of free gifts.Chapters: 00:00 Why Dietary Guidelines Exist and Why This Moment Matters01:20 The Hidden Origins of the Food Pyramid (World War II + Public Health)02:55 The Original Protein RDA: A Basement Number, Not Optimal Health05:50 Why the Old Guidelines Focused on What Not to Eat07:25 Why Protein Was Avoided for Decades08:50 Nitrogen Balance: Why It Never Predicted Health Outcomes11:10 Epidemiology vs Controlled Trials in Nutrition Science13:05 How the Protein Evidence Was Evaluated for the New Guidelines14:15 Why Higher Protein Improves Weight, Fat Loss, and Lean Mass15:35 Is “Too Much Protein” Actually Dangerous?16:40 Nutrient Deficiencies Risk on Low-Protein Diets17:35 Animal vs Plant Protein: Bioavailability and Amino Acids18:45 Why 0.8 g/kg Was Never Better Than Higher Protein20:15 Empowering Consumers Instead of One-Size-Fits-All Nutrition21:10 How Guidelines Shape School Lunches, Hospitals, and the Military23:05 Protein-First Meal Planning Explained24:50 Why the First Meal Matters More as You Age27:15 Does Protein Distribution Matter After 50?30:00 Protein, Satiety, and Appetite Control31:05 Why “Ounce Equivalents” Between Plant and Animal Protein Don’t Work34:05 The Saturated Fat Myth and Why the 10% Rule Persists38:30 Where Saturated Fat Really Comes From in the Modern Diet39:45 Updated Fruit, Vegetable, and Grain Recommendations40:45 Carbohydrate Tolerance and Energy Needs42:45 Why RDAs, DRIs, and Guidelines Create Confusion44:20 Politics, Institutions, and Resistance to Change46:10 Why These Guidelines Are Different This Time47:25 Science Over Ideology: What the Report Gets Right48:35 Where to Find the Full Guidelines and Supporting Evidence50:50 Final Takeaway: Protein as the Organizing Principle of NutritionFind Dr. Layman on X: https://x.com/donlaymanFind Dr. Gabrielle Lyon at: Instagram: @drgabriellelyon TikTok: @drgabriellelyonFacebook: facebook.com/doctorgabriellelyonYouTube: youtube.com/@DrGabrielleLyonX (Twitter): x.com/drgabriellelyonApply to become a patient – https://drgabriellelyon.com/new-patient-inquiry/Order The Forever Strong PLAYBOOK - https://drgabriellelyon.com/playbook/Disclaimers: This episode includes paid sponsorships.The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.
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51 MIN
The Forever Strong PLAYBOOK: Your 6-Week Field Manual for Muscle-Centric Longevity
JAN 27, 2026
The Forever Strong PLAYBOOK: Your 6-Week Field Manual for Muscle-Centric Longevity
Order The Forever Strong PLAYBOOK: https://drgabriellelyon.com/playbook/Want ad-free episodes? Subscribe to Forever Strong Insider: https://foreverstrong.supercast.comIn this solo episode, Dr. Gabrielle Lyon shares the deeper mission behind The Forever Strong PLAYBOOK and the philosophy that has guided her work for decades.This conversation is not about trends, quick fixes, or aesthetics. It is about building strength as a lifelong responsibility and understanding why skeletal muscle is the foundation of health, resilience, and independence across the lifespan.Dr. Lyon introduces the Forever Strong ethos and walks through the four foundational pillars that support a strong life: how to think, how to eat, how to move, and how to recover. She explains why information alone does not change behavior and why clarity, discernment, and disciplined action are the true drivers of lasting health.Throughout the episode, Dr. Lyon challenges conventional narratives around aging, nutrition, exercise, and recovery. She reframes longevity through the lens of muscle span, the length of time a person lives with healthy, functional skeletal muscle, and explains how physical strength supports metabolic health, emotional regulation, and cognitive resilience.This episode is an invitation to step out of confusion and into a clear framework for living with intention. Strength is not something we inherit. It is something we build, choice by choice, day by day.Thank you to our sponsors: Timeline - Get 35% off a Mitopure subscription at https://www.timeline.com/drlyonFour Sigmatic - Go to http://foursigmatic.com/gabrielle for a free bag of their dark roast ground coffee (just pay for shipping & handling).Find Dr. Gabrielle Lyon at: Instagram:@drgabriellelyonTikTok: @drgabriellelyonFacebook: facebook.com/doctorgabriellelyonYouTube: youtube.com/@DrGabrielleLyonX (Twitter): x.com/drgabriellelyonTimestamps: 00:00 – The Forever Strong Mission01:15 – The Forever Strong Ethos06:00 – Muscle as the Organ of Longevity09:40 – How to Think10:24 – Using the Body to Train the Mind19:41 – Discernment and Mental Strength28:43 – How to Eat38:10 – Protein, Carbohydrates, and Metabolic Health48:04 – Food Quality and Nutrient Density51:30 – How to Move57:59 – Training for Strength and Sustainability1:06:39 – How to Recover1:12:00 – Forever StrongDisclaimers: This episode includes paid sponsorships.The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.
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72 MIN
You Don’t Need Confidence, Just Do THIS | Leila Hormozi
JAN 20, 2026
You Don’t Need Confidence, Just Do THIS | Leila Hormozi
Pre-order The Forever Strong PLAYBOOK today to unlock over $400 in free bonuses and learn how to build the muscle, resilience, and metabolic health that actually determine how well you age. https://drgabriellelyon.com/playbook/Want ad-free episodes? Subscribe to Forever Strong Insider: https://foreverstrong.supercast.comIn this episode, Gabrielle Lyon sits down with Leila Hormozi to discuss the journey from grit to empathy in both personal and professional life. Leila shares candid stories of building her first business, the sacrifices involved, and how her experiences in fitness shaped her entrepreneurial mindset. The conversation explores the value of failure, the importance of discipline, and what it truly takes to achieve business success, reflecting on the unique challenges and rewards that women encounter in leadership roles.Gabrielle and Leila also open up about balancing ambition, relationships, and personal well-being. They address how to build trust, practice self-belief, and handle the pressures of being public figures with authenticity. You will find practical insights on navigating discomfort, the importance of continuous growth, and on creating a fulfilling life based on clear priorities and honest reflection. The episode is filled with relatable stories and actionable advice for anyone focused on self-development and leadership.Chapters: 0:00 – From Grit to Empathy: How Leila’s Perspective Shifted1:33 – Why Fitness Built the Foundation for Business Success3:38 – Confidence, Self-Belief, and the Difference Between Rookie and Seasoned Entrepreneurs8:23 – Discomfort, Anxiety, and Paying the Price for Growth12:58 – Becoming Public-Facing and Outgrowing the Persona You Created16:01 – Creating Content Without a Funnel or Ego-Driven Motives19:32 – Why Fewer Women Teach Business at Scale22:42 – What Actually Makes a Business Legitimate24:23 – Trust, Relationships, and Learning to Trust Yourself26:38 – Success vs Happiness and the Tradeoffs People Ignore31:56 – Sacrifice by Season: Constraints, Focus, and Capacity35:14 – Personal Trade-Offs and the Real Cost of Success36:50 – Growth Levels Are About Exposure, Not Time37:25 – Why You Should Stress Yourself Out More (Short-Term)43:04 – Social Media, Authenticity, and Being Fully Human46:15 – Reading Psychology and Understanding Culture48:19 – Maintaining Relationships Between High Achievers54:19 – Renegotiating Relationship Roles as Life Evolves59:54 – Belief Is an Output, Not an Input1:04:07 – Changing Your Relationship With Discomfort1:04:55 – What’s Next: Expansion, Health, and Long-Term VisionThank you to our sponsors: OneSkin - Get 15% off at https://www.oneskin.co/ with code DRLYONBodyHealth - Get 20% off your first order with code LYON20 https://www.bodyhealthaffiliates.com/73L4QL3/7XDN2/Bon Charge - Save 15% at https://boncharge.com/ with code DRLYONFind Leila Hormozi at: IG: https://www.instagram.com/leilahormozi/YouTube: https://www.youtube.com/@leilahormoziFind Dr. Gabrielle Lyon at: Instagram: @drgabriellelyonTikTok: @drgabriellelyonFacebook: facebook.com/doctorgabriellelyonYouTube: youtube.com/@DrGabrielleLyonX (Twitter): x.com/drgabriellelyonApply to become a patient – https://drgabriellelyon.com/new-patient-inquiry/Pre-order my new book - https://www.amazon.com/exec/obidos/ASIN/1668085623Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions. This episode includes paid sponsorships.
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67 MIN
Willpower vs. Systems: Why Your Diet Fails & How to Fix Your Relationship w/ Food | Sohee Carpenter
JAN 13, 2026
Willpower vs. Systems: Why Your Diet Fails & How to Fix Your Relationship w/ Food | Sohee Carpenter
Pre-Order The Forever Strong PLAYBOOK and receive exclusive bonuses: https://drgabriellelyon.com/playbook/ Want ad-free episodes, exclusives and access to community Q&As? Subscribe to Forever Strong Insider: https://foreverstrong.supercast.com In this episode, Dr. Gabrielle Lyon is joined by Sohee Carpenter, PhD, to explore the complex intersection of psychology, eating behavior, and resistance training. Dr. Carpenter shares her personal journey from struggling with eating disorders to becoming a leading expert in sports science, offering a unique perspective on why high achievers often struggle with diet adherence. They dive deep into the science of behavior change, emphasizing that willpower is a finite resource and that true success lies in building automatic, cognitively effortless habits. Dr. Carpenter debunks common fitness myths, including the necessity of "lifting heavy" and the supposed ineffectiveness of circuit training, while providing practical strategies like "habit stacking" and "designing for laziness" to help listeners navigate their own health journeys. Chapter Markers - 0:00 - Intro: The finite nature of exercise vs. the 24/7 challenge of nutrition. - 1:22 - Meet Sohee Carpenter, PhD: Her academic journey from Stanford Biology to a PhD in Sports Science. - 4:33 - Personal Struggles: Overcoming anorexia, bulimia, and long-term binge eating. - 5:41 - Cultural Pressures: Growing up with the beauty standards of Korea vs. the US. - 8:38 - The Fitness Hobbyist: Discovering weights and the "clean eating" trap in 2011. - 13:10 - The Career Pivot: Choosing Psychology and Fitness over Medical School. - 17:52 - The Binge-Restrict Cycle: Why trying "harder" and being stricter backfires. - 21:54 - Defining RMR: Understanding Resting Metabolic Rate as your caloric floor. - 29:26 - Binge Eating Triggers: Emotion regulation and poor stress coping mechanisms. - 33:10 - The Freedom of No "Food Noise": Intuitive eating as a learned skill. - 36:08 - Gentle Nutrition: The "Add, Don’t Restrict" mindset. - 38:46 - The Willpower Battery: Why habits are superior to brute force discipline. - 45:47 - Habits and Environment: How to "Design for Laziness". - 50:00 - Habit Stacking: Pairing new behaviors with existing daily rituals. - 55:04 - Last Chance Syndrome: The logic of a binge and the "all or nothing" mentality. - 1:00:13 - Cognitive Distortions: Catastrophizing and the "bird's eye view" reframe. - 1:04:36 - Dichotomous Thinking: Why black-and-white mindsets lead to binging. - 1:06:48 - Intrinsic vs. Extrinsic Motivation: Finding a "why" that lasts. - 1:12:34 - Identity Change: Perceiving yourself as the person you want to become. - 1:14:27 - Resistance Training for Women: Determining the ideal frequency and style. - 1:19:16 - National Muscle Health Month: Elevating muscle as a pillar of health. - 1:21:39 - The "Heavy Lifting" Myth: Using rep ranges and reps in reserve (RIR). - 1:26:13 - The Circuit Training Study: Similar muscle gains in 25 minutes less time. - 1:29:44 - Training Fasted: Dispelling misconceptions for women’s metabolic health. - 1:30:57 - Running while Pregnant: Staying capable and medically cleared. - 1:33:34 - Final Takeaways: Incremental change and a holistic view of health. Thank you to our sponsors: Four Sigmatic - Go to http://foursigmatic.com/gabrielle for a free bag of their dark roast ground coffee (just pay for shipping & handling).Cozy Earth - Go to https://www.cozyearth.com/DRLYON for up to 20% off! Our Place - Visit https://www.fromourplace.com/DRLYON and use code DRLYON for 10% off sitewide.Find Sohee Carpenter at: - IG: https://www.instagram.com/soheefit - Youtube: @SoheeFit Find Dr. Gabrielle Lyon at: - Instagram:@drgabriellelyon - TikTok: @drgabriellelyon - Facebook: facebook.com/doctorgabriellelyon - YouTube: youtube.com/@DrGabrielleLyon - X (Twitter): x.com/drgabriellelyon - Apply to become a patient – https://drgabriellelyon.com/new-patient-inquiry/ - Join my weekly newsletter – https://institute-for-muscle-centric-medicine.ck.page - Pre-order my new book - https://www.amazon.com/exec/obidos/ASIN/1668085623 Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions. This episode includes paid sponsorships.
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95 MIN
The Gut-Muscle-Immune Axis: How Mitophagy Rewires Your Body for Longevity
JAN 6, 2026
The Gut-Muscle-Immune Axis: How Mitophagy Rewires Your Body for Longevity
Pre-Order The Forever Strong PLAYBOOK and receive exclusive bonuses: https://drgabriellelyon.com/playbook/Want ad-free episodes, exclusives and access to community Q&As? Subscribe to Forever Strong Insider: https://foreverstrong.supercast.comAre your immune cells aging faster than you are? In this episode, Dr. Gabrielle Lyon sits down with Dr. Anurag Singh, a leading physician-researcher and Chief Medical Officer at Timeline, to discuss a groundbreaking discovery: the gut-muscle-immune axis. While we often focus on muscle mass for longevity, new research published in Nature Aging reveals that our immune system undergoes a similar decline, with youthful sentinel cells (naive CD8 T-cells) dropping by 75% as we reach age 50. Dr. Singh explains how mitophagy —the targeted recycling of damaged mitochondria—is the key to "rewiring" an aging immune system to fight infection 20% more effectively. In this episode: Alzheimer’s of the Muscle: Why sporadic inclusion body myositis (sIBM) is often misdiagnosed as simple aging. The Power of Urolithin A: How this postbiotic compound induces mitophagy to increase mitochondrial abundance by 20% in just 28 days. Immune Imprinting: Why children get 6-8 colds a year while adults only average 2-4. Repurposing Longevity Drugs: Dr. Singh’s take on Metformin, Rapamycin, and GLP-1s for life extension. The 1:1 Exercise Rule:Why 150 minutes of moderate activity is the threshold for mitochondrial biogenesis. Thank you to our sponsors: BodyHealth - Use the code LYON 20 to get 20% off your first order https://www.bodyhealthaffiliates.com/73L4QL3/7XDN2/ Timeline - Get 35% off a Mitopure subscription at https://www.timeline.com/drlyon Manukora - Go to https://www.MANUKORA.com/DRLYON to save 31% plus $25 worth of free gifts. Chapters: 0:00 - Can You Tell If Your Immune System Is Healthy? 1:37 - Alzheimer’s of the Muscle: Muscle-Immune Dysfunction 5:59 - The Thymus Design Flaw: Why Our Immune "Ammo" Disappears 8:44 - Naive CD8 T-Cells: The Elite Forces of Immunity 12:24 - The Axis of Aging: Mitochondria and Immune Cells in Muscle 16:15 - Mitophagy vs. Autophagy: Targeted Cellular Recycling 19:11 - Study Review: Rewiring the Immune System with Urolithin A 24:13 - Mitochondrial Remodeling: Switching from Glucose to Fatty Acids 27:45 - The Trifecta: Gut-Muscle-Immune Axis Connection 31:13 - Parkinson’s and the PINK1/Parkin Mitophagy Pathway 35:04 - Clinical Results: Improving Leg Strength in 4 Months 38:51 - Joint Health: Can We Remodel Cartilage with Mitophagy? 43:34 - Targeted Mitophagy Inducers: Exercise vs. Postbiotics 46:44 - Precision Nutrition: The Ideal Muscle Longevity Supplement 53:33 - Why Alzheimer’s is Now Considered an Inflammatory Disease 1:00:13 - The Placebo Effect: You Cannot Deceive the Immune System 1:03:13 - Lymphocyte Counts: The Clinical Marker for Immune Aging 1:08:14 - Rapamycin and Metformin: The Future of Longevity Drugs 1:11:42 - Optimal Dosing: Why 1,000mg of Urolithin A is the Standard 1:15:13 - Sports Medicine: Reducing Muscle Damage Markers (Creatine Kinase) 1:20:03 - The Final Frontier: Brain Aging and Selenium Repair Connect with Dr. Anurag Singh Instagram: @timeline_longevity Website: https://www.timeline.comFind Dr. Gabrielle Lyon at: Instagram:@drgabriellelyon TikTok: @drgabriellelyonFacebook: facebook.com/doctorgabriellelyonYouTube: youtube.com/@DrGabrielleLyonX (Twitter): x.com/drgabriellelyonApply to become a patient – https://drgabriellelyon.com/new-patient-inquiry/Join my weekly newsletter – https://institute-for-muscle-centric-medicine.ck.pagePre-order my new book - https://www.amazon.com/exec/obidos/ASIN/1668085623 Disclaimers: This episode includes paid sponsorships. The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.
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83 MIN