Why Tuberculosis is still the most deadly infectious disease. Attention, DNA detectives! We’ve got a rat on the loose – but don’t worry, not the snitching, double-agent kind. We’re talking about the whiskered, hyper-skilled, tiny agents who aren't snitching - they're sniffing out one of the world’s deadliest diseases: tuberculosis (TB). Tuberculosis might sound old-timey, but it’s still the globe’s top infectious killer– growing tougher, more drug-resistant, and hitting hardest where access to care falls short. So for our Season 5 finale, host Dr. Kaylee Byers digs into TB’s fascinating backstory, and teams up with microbiologist Dr. Jennifer Guthrie to figure out why this ancient disease still has such a tight grip, and how genomics is helping track its every move. Along the way, Dr. Zolelwa Sifumba shares her story as a multidrug-resistant TB survivor, and how her treatment journey fuels her advocacy today. Buckle up: this investigation has it all : science, politics, global inequities… and a squad of extraordinary rats. Special thanks to APOPO for sending us field recordings and interviews from their HeroRAT training program. Highlights (3:42) The history of TB(8:19) Why TB sits at the top of the global disease podium(15:30) Meet Zolelwa - a multi-drug-resistant TB survivor(30:48) The power of education – Show Notes/Resources:1.&nbsp;<a href="https://education.nationalgeographic.org/resource/giant-rats-trained-sniff-out-tuberculosis-africa/" target="_blank" style="color: rgb(35, 119, 210);">Giant Rats Trained to Sniff Out Tuberculosis in Africa</a>- National Geographic2.&nbsp;<a href="https://apopo.org/how-herorats-are-trained/?v=5435c69ed3bc#:~:text=At%20APOPO%2C%20we%20believe%20that,places%20where%20these%20challenges%20persist." target="_blank" style="color: rgb(35, 119, 210);">The Making of a HeroRAT: From Tiny Pup to Life-saving Hero</a>- APOPO3.&nbsp;<a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7263063/" target="_blank" style="color: rgb(35, 119, 210);">Tuberculosis: an ancient disease that remains a medical, social, economical and ethical issue</a>- Journal of Preventive Medicine and Hygiene4.&nbsp;<a href="https://www.cdc.gov/world-tb-day/history/index.html" target="_blank" style="color: rgb(35, 119, 210);">History of World TB Day</a>- CDC5.&nbsp;<a href="https://www.sciencedirect.com/science/article/pii/S095461110600401X?utm_" target="_blank" style="color: rgb(35, 119, 210);">The history of tuberculosis</a>- Respiratory Medicine6.&nbsp;<a href="https://www.tandfonline.com/doi/full/10.1080/24745332.2022.2041328#d1e274" target="_blank" style="color: rgb(35, 119, 210);">Chapter 12: An introductory guide to tuberculosis care to improve cultural competence for health care workers and public health professionals serving Indigenous Peoples of Canada</a>- Canadian Journal of Respiratory, Critical Care, and Sleep Medicine7.&nbsp;<a href="https://everythingistb.com/" target="_blank" style="color: rgb(35, 119, 210);">Everything is Tuberculosis</a>-&nbsp;John Green

<description>&lt;p&gt;&lt;em style="color: rgb(43, 55, 62);"&gt;Why Tuberculosis is still the most deadly infectious disease.&lt;/em&gt;&lt;/p&gt;&lt;p&gt;&lt;br&gt;&lt;/p&gt;&lt;p&gt;&lt;span style="color: rgb(43, 55, 62);"&gt;Attention, DNA detectives! We’ve got a rat on the loose – but don’t worry, not the snitching, double-agent kind. We’re talking about the whiskered, hyper-skilled, tiny agents who aren't snitching - they're sniffing out one of the world’s deadliest diseases: tuberculosis (TB).&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;br&gt;&lt;/p&gt;&lt;p&gt;&lt;span style="color: rgb(43, 55, 62);"&gt;Tuberculosis might sound old-timey, but it’s still the globe’s top infectious killer– growing tougher, more drug-resistant, and hitting hardest where access to care falls short. So for our Season 5 finale, host Dr. Kaylee Byers digs into TB’s fascinating backstory, and teams up with microbiologist Dr. Jennifer Guthrie to figure out why this ancient disease still has such a tight grip, and how genomics is helping track its every move. Along the way, Dr. Zolelwa Sifumba shares her story as a multidrug-resistant TB survivor, and how her treatment journey fuels her advocacy today.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;br&gt;&lt;/p&gt;&lt;p&gt;&lt;span style="color: rgb(43, 55, 62);"&gt;Buckle up: this investigation has it all : science, politics, global inequities… and a squad of extraordinary rats.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;br&gt;&lt;/p&gt;&lt;p&gt;&lt;span style="color: rgb(43, 55, 62);"&gt;Special thanks to APOPO for sending us field recordings and interviews from their &lt;/span&gt;&lt;span style="color: rgb(32, 33, 34);"&gt;HeroRAT&lt;/span&gt;&lt;span style="color: rgb(43, 55, 62);"&gt; training program.&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;br&gt;&lt;/p&gt;&lt;p&gt;&lt;strong style="color: rgb(43, 55, 62);"&gt;Highlights&lt;/strong&gt;&lt;/p&gt;&lt;p&gt;&lt;br&gt;&lt;/p&gt;&lt;p&gt;&lt;strong&gt;(3:42) &lt;/strong&gt;The history of TB&lt;/p&gt;&lt;p&gt;&lt;strong&gt;(8:19) &lt;/strong&gt;Why TB sits at the top of the global disease podium&lt;/p&gt;&lt;p&gt;&lt;strong&gt;(15:30)&lt;/strong&gt; Meet Zolelwa - a multi-drug-resistant TB survivor&lt;/p&gt;&lt;p&gt;&lt;strong&gt;(30:48)&lt;/strong&gt; The power of education&lt;/p&gt;&lt;p&gt;&lt;br&gt;&lt;/p&gt;&lt;p&gt;&lt;strong style="color: rgb(43, 55, 62);"&gt;–&lt;/strong&gt;&lt;/p&gt;&lt;p&gt;&lt;br&gt;&lt;/p&gt;&lt;p&gt;&lt;strong style="color: rgb(43, 55, 62);"&gt;Show Notes/Resources:&lt;/strong&gt;&lt;/p&gt;&lt;p&gt;&lt;span style="color: rgb(43, 55, 62);"&gt;1.&amp;nbsp;&lt;/span&gt;&lt;a href="https://education.nationalgeographic.org/resource/giant-rats-trained-sniff-out-tuberculosis-africa/" target="_blank" style="color: rgb(35, 119, 210);"&gt;&lt;strong&gt;Giant Rats Trained to Sniff Out Tuberculosis in Africa&lt;/strong&gt;&lt;/a&gt;&lt;span style="color: rgb(43, 55, 62);"&gt;- National Geographic&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span style="color: rgb(43, 55, 62);"&gt;2.&amp;nbsp;&lt;/span&gt;&lt;a href="https://apopo.org/how-herorats-are-trained/?v=5435c69ed3bc#:~:text=At%20APOPO%2C%20we%20believe%20that,places%20where%20these%20challenges%20persist." target="_blank" style="color: rgb(35, 119, 210);"&gt;&lt;strong&gt;The Making of a HeroRAT: From Tiny Pup to Life-saving Hero&lt;/strong&gt;&lt;/a&gt;&lt;span style="color: rgb(43, 55, 62);"&gt;- APOPO&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span style="color: rgb(43, 55, 62);"&gt;3.&amp;nbsp;&lt;/span&gt;&lt;a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7263063/" target="_blank" style="color: rgb(35, 119, 210);"&gt;&lt;strong&gt;Tuberculosis: an ancient disease that remains a medical, social, economical and ethical issue&lt;/strong&gt;&lt;/a&gt;&lt;span style="color: rgb(43, 55, 62);"&gt;- Journal of Preventive Medicine and Hygiene&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span style="color: rgb(43, 55, 62);"&gt;4.&amp;nbsp;&lt;/span&gt;&lt;a href="https://www.cdc.gov/world-tb-day/history/index.html" target="_blank" style="color: rgb(35, 119, 210);"&gt;&lt;strong&gt;History of World TB Day&lt;/strong&gt;&lt;/a&gt;&lt;span style="color: rgb(43, 55, 62);"&gt;- CDC&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span style="color: rgb(43, 55, 62);"&gt;5.&amp;nbsp;&lt;/span&gt;&lt;a href="https://www.sciencedirect.com/science/article/pii/S095461110600401X?utm_" target="_blank" style="color: rgb(35, 119, 210);"&gt;&lt;strong&gt;The history of tuberculosis&lt;/strong&gt;&lt;/a&gt;&lt;span style="color: rgb(43, 55, 62);"&gt;- Respiratory Medicine&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;strong style="color: rgb(43, 55, 62);"&gt;6.&amp;nbsp;&lt;/strong&gt;&lt;a href="https://www.tandfonline.com/doi/full/10.1080/24745332.2022.2041328#d1e274" target="_blank" style="color: rgb(35, 119, 210);"&gt;&lt;strong&gt;Chapter 12: An introductory guide to tuberculosis care to improve cultural competence for health care workers and public health professionals serving Indigenous Peoples of Canada&lt;/strong&gt;&lt;/a&gt;&lt;span style="color: rgb(43, 55, 62);"&gt;- Canadian Journal of Respiratory, Critical Care, and Sleep Medicine&lt;/span&gt;&lt;/p&gt;&lt;p&gt;&lt;span style="color: rgb(43, 55, 62);"&gt;7.&amp;nbsp;&lt;/span&gt;&lt;a href="https://everythingistb.com/" target="_blank" style="color: rgb(35, 119, 210);"&gt;&lt;strong&gt;Everything is Tuberculosis&lt;/strong&gt;&lt;/a&gt;&lt;strong style="color: rgb(43, 55, 62);"&gt;-&lt;/strong&gt;&lt;span style="color: rgb(43, 55, 62);"&gt;&amp;nbsp;John Green&lt;/span&gt;&lt;/p&gt;</description>

Why Tuberculosis is still the most deadly infectious disease.Attention, DNA detectives! We’ve got a rat on the loose – but don’t worry, not the snitching, double-agent kind. We’re talking about the whiskered, hyper-skilled, tiny agents who aren't s...

Nice Genes!

TB Trails and Tails

TB Trails and Tails

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