In this episode of RAPM Focus, Editor in Chief Brian Sites, MD, discusses the pros and cons of perioperative gabapentinoids with author and RAPM Executive Editor Eric Schwenk, MD, and Kishor Gandhi, MD, following the November 2025 publication of his brief technical report, “Pro-con debate on perioperative gabapentinoids: a nuanced approach is the best one.” Dr. Eric Schwenk is a professor of anesthesiology and perioperative medicine at the Sidney Kimmel Medical College at Thomas Jefferson University in Philadelphia, PA and is the vice chair of faculty affairs and professional development. His clinical and research interests are outcomes after orthopedic surgery, chronic postsurgical pain, and ketamine in migraine. He serves on the ASRA Pain Medicine Guidelines and Regulatory Advocacy Committee. Dr. Kishor Gandhi is a clinical associate professor and associate residency director at Virtua College of Medicine and Life Sciences at Rowan University in New Jersey. His clinical interests include regional anesthesia and acute pain. Dr. Gandhi has been in clinical practice for 20 years. *The purpose of this podcast is to educate and to inform. The content of this podcast does not constitute medical advice, and it is not intended to function as a substitute for a healthcare practitioner’s judgement, patient care, or treatment. The views expressed by contributors are those of the speakers. BMJ does not endorse any views or recommendations discussed or expressed on this podcast. Listeners should also be aware that professionals in the field may have different opinions. By listening to this podcast, listeners agree not to use its content as the basis for their own medical treatment or for the medical treatment of others. Podcast and music produced by Dan Langa. Find us on X @RAPMOnline, LinkedIn @Regional Anesthesia & Pain Medicine, Facebook @Regional Anesthesia & Pain Medicine, and Instagram @RAPM_Online.