<p>Cremieux went from arguing against the death penalty as a teenager to becoming one of the most influential voices dissecting science online. Now with 250k+ followers on X, he’s known for exposing p-hacking, outcome switching, and selection effects that skew research.</p><p>In this conversation with Niklas, here’s what they actually talk about: why effect sizes in journals rarely match FDA data, how gene therapy’s real bottleneck is delivery not targets, and why siRNA is the most underrated modality in biotech right now.</p><p><strong>What you’ll hear in this episode:</strong></p><p>* The heuristics he uses to spot bad research at a glance</p><p>* Why published effect sizes are often 2–3x inflated compared to FDA data</p><p>* Selection effects that quietly shape everything from education outcomes to clinical trials</p><p>* The real bottleneck in gene therapy (delivery, not targets) and why germline bans hold back obvious wins</p><p>* How pragmatic trials and IRB reform could finally fix a broken system</p><p>* Why measles might come back and the case for vaccine mandates for kids</p><p>* The truth about longevity research: most “breakthroughs” just stop early deaths, not extend the right tail</p><p>* China’s clinical trial engine vs the slow US system</p><p>* The modality he thinks is most underpriced today: siRNA</p><p>For builders in science who care more about getting it right than playing along.</p><p><strong>More about GUEST’S work:</strong></p><p>* <a target="_blank" href="https://x.com/cremieuxrecueil">Cremieux’s X</a></p><p><strong>Explore Infinita City:</strong></p><p>* <a target="_blank" href="https://www.infinita.city/times">Explore the Archive: The Infinita City Times</a></p><p>* <a target="_blank" href="https://www.infinita.city">Visit Infinita City</a></p><p>* <a target="_blank" href="https://www.infinita.city/builders-hub">Join the Builders’ Hub on Telegram</a></p><p>* <a target="_blank" href="https://x.com/InfinitaCity">Follow Infinita City on X</a></p> <br/><br/>This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit <a href="https://www.infinitacitytimes.com?utm_medium=podcast&#38;utm_campaign=CTA_1">www.infinitacitytimes.com</a>