<p>In this episode, we explore the emerging entity of CAR Transgenic T-cell Lymphoproliferative Neoplasms (CTTLN), a rare but important complication of CAR T-cell therapy. Dr. Piers Blombery from Peter MacCallum Cancer Center joins us to dissect two cases from the CARTITUDE-4 trial where patients developed T-cell lymphomas expressing the chimeric antigen receptor following cilta-cel treatment for multiple myeloma. As a bonus, we also briefly discussed Dr. Blombery’s paper on menin inhibitors in UBTF tandem duplicated AML. Here are the papers we discussed: </p><p>1. CTTLN cases from CARTITUDE-4: <a href="https://pubmed.ncbi.nlm.nih.gov/39938094/">https://pubmed.ncbi.nlm.nih.gov/39938094/<br></a><br></p><p>2. CTTLN case from MSKCC with insertional mutagenesis: <a href="https://pubmed.ncbi.nlm.nih.gov/39908432/">https://pubmed.ncbi.nlm.nih.gov/39908432/<br></a><br></p><p>3. Other CTTLN cases in myeloma: <br><a href="https://pubmed.ncbi.nlm.nih.gov/38865661/">https://pubmed.ncbi.nlm.nih.gov/38865661/<br></a><a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC8417502/">https://pmc.ncbi.nlm.nih.gov/articles/PMC8417502/<br></a><br></p><p>4. Response and resistance to menin inhibitors in UBTF tandem duplication AML: <a href="https://pubmed.ncbi.nlm.nih.gov/38924737/">https://pubmed.ncbi.nlm.nih.gov/38924737/<br></a><br></p>

Blood Cancer Talks

Rajshekhar Chakraborty, Ashwin Kishtagari, and Edward Cliff

Episode 58: CAR Transgenic T-cell Lymphoproliferative Neoplasms (CTTLN) with Dr. Piers Blombery

MAR 26, 202550 MIN
Blood Cancer Talks

Episode 58: CAR Transgenic T-cell Lymphoproliferative Neoplasms (CTTLN) with Dr. Piers Blombery

MAR 26, 202550 MIN

Description

In this episode, we explore the emerging entity of CAR Transgenic T-cell Lymphoproliferative Neoplasms (CTTLN), a rare but important complication of CAR T-cell therapy. Dr. Piers Blombery from Peter MacCallum Cancer Center joins us to dissect two cases from the CARTITUDE-4 trial where patients developed T-cell lymphomas expressing the chimeric antigen receptor following cilta-cel treatment for multiple myeloma. As a bonus, we also briefly discussed Dr. Blombery’s paper on menin inhibitors in UBTF tandem duplicated AML. Here are the papers we discussed: 

1. CTTLN cases from CARTITUDE-4: https://pubmed.ncbi.nlm.nih.gov/39938094/

2. CTTLN case from MSKCC with insertional mutagenesis: https://pubmed.ncbi.nlm.nih.gov/39908432/

3. Other CTTLN cases in myeloma:
https://pubmed.ncbi.nlm.nih.gov/38865661/
https://pmc.ncbi.nlm.nih.gov/articles/PMC8417502/

4. Response and resistance to menin inhibitors in UBTF tandem duplication AML: https://pubmed.ncbi.nlm.nih.gov/38924737/