<p>In this encore episode, we highlight vitamin D₃ in gastrointestinal health, with a focus on intestinal barrier function and the gut-immune axis. We discuss how vitamin D is metabolized into its active form, 1,25-dihydroxyvitamin D, and how 1,25-dihydroxyvitamin D can support intestinal health, while highlighting intestinal mucosal anatomy.</p><p><br></p><p>Topics:</p><p>1. Introduction </p><p>- Highlighting intestinal barrier function and the gut-immune axis with a focus on vitamin D₃</p><p> </p><p>2. Vitamin D Synthesis and Metabolism </p><p>- Skin and 7-dehydrocholesterol; dietary intake.</p><p>- Transported through the bloodstream bound to vitamin D binding protein.</p><p>- First hydroxylation in the liver to form 25-hydroxyvitamin D₃ (25(OH)D₃).</p><p>- Testing.</p><p>- Second hydroxylation in the kidney to form the active 1,25 dihydroxyvitamin D₃ (1,25(OH)₂D₃).</p><p>- Local activation also occurs.</p><p> </p><p>3. Intestinal Barrier Anatomy </p><p>- The intestinal epithelium forms a selectively permeable monolayer that interfaces with the gut lumen.</p><p>- Covered by a mucus layer.</p><p>- Tight junction proteins and paracellular permeability.</p><p>- The lamina propria and Gut-Associated Lymphoid Tissue (GALT). </p><p>- Maintaining tolerance.</p><p> </p><p> 4. Vitamin D </p><p>- 1,25-dihydroxyvitamin D₃, tight junction integrity, immune regulation, and more.</p><p><br></p><p> 5. Vitamin D₂ and D₃</p><p> </p><p> 6. Conclusion - Neither too high nor too low: optimal levels.</p><p>- Multifactorial: Numerous factors regulate vitamin D levels.</p><p>- Gastrointestinal health root cause approach.</p><p><br></p><p><br></p><p></p><p>Thank you to our episode sponsor: </p><p>1. &quot;<a href="https://longevitywellness.co/pages/chloe-porter">⁠Longevity⁠</a>&quot; with Protein, Probiotics, Bovine Colostrum, Collagen, and More. Use code <a href="https://longevitywellness.co/pages/chloe-porter">⁠CHLOE⁠</a> for 25% off.</p><p><br></p><p>*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.</p><p><br></p><p><br></p><p>Thanks for tuning in!</p><p>Follow Chloe on Instagram <a href="https://www.instagram.com/synthesisofwellness/">⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠</a></p><p>Visit <a href="https://www.synthesisofwellness.com/">⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠</a></p><p></p><p><br></p><p><br></p><p><br></p>