Neuroscience Perspectives
Neuroscience Perspectives

Neuroscience Perspectives

Del Monte Institute for Neuroscience at the University of Rochester

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Episodes

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Immerse yourself in the fascinating world of neuroscience with our expert guests as they explore the mysteries of the brain and the latest breakthroughs in research with our host, John Foxe, PhD, director of the Del Monte Institute for Neuroscience at the University of Rochester.

Each episode features in-depth conversations with leading scientists, who unravel complex topics and tackle intriguing questions like: How does the brain shape our behavior? What role do genetics play in our health? How do early life experiences shape brain function and critical periods of brain development? Listen as they share their unique journeys to neuroscience research, lessons learned from the bench, and discoveries that transform our understanding of neurodevelopmental diseases and disorders like autism and Rett syndrome and neurodegenerative diseases like Alzheimer’s and Parkinson’s.

Whether you’re a seasoned scientist or just curious about the brain, our podcast will spark your interest, expand your understanding of this dynamic field, and lift the veil on how leaders in brain research made it to where they are today. Don’t miss out on your journey into the depths of neuroscience with experts from around the world—subscribe now!

Recent Episodes

Neuroscience & RNA Biology: How mRNA Decay Shapes Health & Disease
MAR 27, 2025
Neuroscience & RNA Biology: How mRNA Decay Shapes Health & Disease
<p>How does RNA biology influence cell function, gene expression, and disease mechanisms? In this episode of Neuroscience Perspectives, host John Foxe, PhD, director of the Del Monte Institute for Neuroscience at the University of Rochester (UR), sits down with Lynne Maquat, PhD, director of the Center for RNA Biology at UR, and J. Lowell Orbison Endowed Chair and Professor of Biochemistry &amp; Biophysics, to explore groundbreaking research in mRNA decay, cellular quality control, and translational research. Dr. Maquat, a world-renowned scientist, shares insights into how fundamental biochemistry, molecular biology, and biophysics drive scientific discovery—from understanding cystic fibrosis, fragile X syndrome, and intellectual disabilities to advancing cancer research, autism studies, and stem cell research. They also discuss the impact of mRNA vaccines, vaccine development, and COVID-19 on modern medicine. Beyond the lab, they dive into the importance of scientific integrity, mentoring scientists, research collaboration, and science education. </p><p>🔬 Discover how basic and applied research pave the way for personalized treatments, neurobiology breakthroughs, and scientific innovation. #Neuroscience #RNABiology #ScientificDiscovery </p><p>#mRNADecay #GeneExpression #TranslationalResearch #CancerResearch #VaccineDevelopment #AutismResearch #StemCellResearch #ScienceEducation #ScienceCommunication</p><p> 🧠 Stay Connected </p><p>Subscribe: <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.youtube.com/@URNeuroscience">https://www.youtube.com/@URNeuroscience</a> </p><p>X: <a target="_blank" rel="noopener noreferrer nofollow" href="https://x.com/URNeuroscience">https://x.com/URNeuroscience</a> </p><p>BlueSky: <a target="_blank" rel="noopener noreferrer nofollow" href="https://bsky.app/profile/urneuroscience.bsky.social">https://bsky.app/profile/urneuroscience.bsky.social</a> </p><p>LinkedIn: <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.linkedin.com/company/urneuroscience/">https://www.linkedin.com/company/urneuroscience/</a> </p><p>🧠 Experts in this Episode: </p><p>Lynne Maquat, PhD: <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.urmc.rochester.edu/people/112359023-lynne-e-maquat">https://www.urmc.rochester.edu/people/112359023-lynne-e-maquat</a> John Foxe, PhD: <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.urmc.rochester.edu/people/112360965-john-j-foxe">https://www.urmc.rochester.edu/people/112360965-john-j-foxe</a> </p><p>🧠 Labs Mentioned: </p><p>Maquat Lab: <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.urmc.rochester.edu/labs/maquat">https://www.urmc.rochester.edu/labs/maquat</a> </p><p>Frederick J. and Marion A. Schindler Cognitive Neurophysiology Lab: <a target="_blank" rel="noopener noreferrer nofollow" href="https://urmc.info/1RG">https://urmc.info/1RG</a></p>
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33 MIN
Your Brain & Perception: Using Science to Understand How We See the World
FEB 27, 2025
Your Brain & Perception: Using Science to Understand How We See the World
<p>How brain dynamics, perception, and neural processing offer a deeper understanding of how brain activity shapes our understanding of the world. Christopher Moore, PhD, associate director of the Carnegie Institute of Brain Science and professor of Neuroscience at Brown University, joins Neuroscience Perspectives host John Foxe, PhD, director of the Del Monte Institute for Neuroscience at the University of Rochester, in a fascinating discussion that includes why the term neuroscience may be outdated. Dive into Moore’s research that studies neocortical dynamics – changes in brain activity at the millisecond to the second timescale—and how his lab aims to understand the mechanisms at play and what these changes mean for perception. He and Dr. Foxe also share how they met during a pivotal moment in their careers, which was also a profound moment in neuroscience research. #neuroscience #brainscience #perception #podcast </p><p></p><p>🧠Stay Connected </p><p>Subscribe: <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.youtube.com/@URNeuroscience">https://www.youtube.com/@URNeuroscience</a> </p><p>X: <a target="_blank" rel="noopener noreferrer nofollow" href="https://x.com/URNeuroscience">https://x.com/URNeuroscience</a> </p><p>BlueSky: <a target="_blank" rel="noopener noreferrer nofollow" href="https://bsky.app/profile/urneuroscience.bsky.social">https://bsky.app/profile/urneuroscience.bsky.social</a> </p><p>LinkedIn: <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.linkedin.com/company/urneuroscience/">https://www.linkedin.com/company/urneuroscience/</a></p><p></p><p>🧠Experts in this Episode: </p><p>Christopher Moore, PhD: <a target="_blank" rel="noopener noreferrer nofollow" href="https://vivo.brown.edu/display/cm78">https://vivo.brown.edu/display/cm78</a> </p><p>John Foxe, PhD: <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.urmc.rochester.edu/people/112360965-john-j-foxe">https://www.urmc.rochester.edu/people/112360965-john-j-foxe</a></p><p> </p><p>🧠Labs Mentioned: </p><p>The Moore Lab: <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.themoorelab.org/">https://www.themoorelab.org/</a> </p><p>Frederick J. and Marion A. Schindler Cognitive Neurophysiology Lab: <a target="_blank" rel="noopener noreferrer nofollow" href="https://urmc.info/1RG">https://urmc.info/1RG</a></p>
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35 MIN
Recovering From Stroke - How Physical Therapy & Neuroscience are Advancing Care
JAN 30, 2025
Recovering From Stroke - How Physical Therapy & Neuroscience are Advancing Care
<p>The intersection of stroke rehabilitation &amp; neuroscience research is transforming our understanding of the brain and recovery after a stroke. </p><p>Catherine Lang, PT, PhD, Barbara J Norton Professor of Physical Therapy, Professor of Neurology and Occupational Therapy, and Associate Director of the Movement Science Program at the University of Washington in St. Louis, shares expert insights into stroke therapy, the challenges of regaining motor function, and how personal and environmental factors impact rehabilitation outcomes. Dr. Lang is a WashU graduate who completed her postdoctoral studies in a neuroscience lab at the University of Rochester School of Medicine and Dentistry. She shares how the education and mentorship she received played a role in the mentor she is today. She also gives insight into how growing up in rural Vermont influenced her interest in movement. </p><p>Join Dr. Lang, and guest host, Jeff Koslofsky, host of The Next Steps Podcast from the University of Rochester School of Medicine and Dentistry, for this enlightening conversation. Don’t forget to like, comment, and follow! </p><p>#neuroscience #stroke #réhabilitation #brain #motorcontrol #neuroplasticity #therapy #strokerecovery </p><p></p><p>🧠Stay Connected </p><p>Subscribe: <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.youtube.com/@URNeuroscience">https://www.youtube.com/@URNeuroscience</a> </p><p>X: <a target="_blank" rel="noopener noreferrer nofollow" href="https://x.com/URNeuroscience">https://x.com/URNeuroscience</a> </p><p>BlueSky: <a target="_blank" rel="noopener noreferrer nofollow" href="https://bsky.app/profile/urneuroscience.bsky.social">https://bsky.app/profile/urneuroscience.bsky.social</a> </p><p></p><p>🧠Check out The Next Steps Podcast: <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.youtube.com/playlist?list=PLhIRpvrMLisrZXbvS3wDHGp_Ke9NE167u">https://www.youtube.com/playlist?list=PLhIRpvrMLisrZXbvS3wDHGp_Ke9NE167u</a> </p><p></p><p>🧠Experts in this Episode Catherine Lang, PT, PhD: <a target="_blank" rel="noopener noreferrer nofollow" href="https://pt.wustl.edu/people/catherine-lang-pt-phd-fapta/">https://pt.wustl.edu/people/catherine-lang-pt-phd-fapta/</a> Lang Research Profile: <a target="_blank" rel="noopener noreferrer nofollow" href="https://profiles.wustl.edu/en/persons/catherine-lang">https://profiles.wustl.edu/en/persons/catherine-lang</a></p>
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16 MIN
What Happens When You Combine AI and Neuroscience?
DEC 19, 2024
What Happens When You Combine AI and Neuroscience?
<p>Can we predict brain health across a lifetime? Just as a knee injury at 20 might cause problems later, researchers are exploring how early brain experiences shape future brain health. In this episode of Neuroscience Perspectives, Dr. Randy McIntosh, Professor and Director at the Institute for Neuroscience and Neurotechnology at Simon Fraser University, discusses groundbreaking insights into brain health, neuroscience, and AI with Dr. John Foxe, Director of the Del Monte Institute for Neuroscience. Learn about the Virtual Brain, an open-source neuroscience platform that simulates human brain function, offering new ways to understand conditions like stroke, epilepsy, and neurodegenerative diseases. Discover how technology, artificial intelligence, and neuroscience are converging to unlock the secrets of the human brain.</p><p> </p><p>Virtual Brain: <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.thevirtualbrain.org/tvb/zwei">https://www.thevirtualbrain.org/tvb/zwei</a></p><p> </p><p>🧠Stay Connected</p><p> </p><p>Subscribe: <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.youtube.com/@URNeuroscience">https://www.youtube.com/@URNeuroscience</a></p><p>X: <a target="_blank" rel="noopener noreferrer nofollow" href="https://x.com/URNeuroscience">https://x.com/URNeuroscience</a></p><p>BlueSky: <a target="_blank" rel="noopener noreferrer nofollow" href="https://bsky.app/profile/urneuroscience.bsky.social">https://bsky.app/profile/urneuroscience.bsky.social</a></p><p> </p><p>🧠 Experts in this Episode</p><p> </p><p>John Foxe, PhD: <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.urmc.rochester.edu/people/112360965-john-j-foxe">https://www.urmc.rochester.edu/people/112360965-john-j-foxe</a></p><p>Randy McIntosh, PhD: <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.sfu.ca/bpk/about/people/faculty/randy-mcintosh.html">https://www.sfu.ca/bpk/about/people/faculty/randy-mcintosh.html</a></p><p> </p><p> 🧠Labs Mentioned</p><p> </p><p>Frederick J. and Marion A. Schindler Cognitive Neurophysiology Lab: <a target="_blank" rel="noopener noreferrer nofollow" href="https://urmc.info/1RG">https://urmc.info/1RG</a></p><p>McIntosh Lab: <a target="_blank" rel="noopener noreferrer nofollow" href="https://www.armcintosh.com/home">https://www.armcintosh.com/home</a></p><p></p><p>#brain #science #podcast</p>
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28 MIN
Unlocking the Brain's Communication Hub: The Power of the Thalamus with Dr. S. Murray Sherman
NOV 19, 2024
Unlocking the Brain's Communication Hub: The Power of the Thalamus with Dr. S. Murray Sherman
<p><strong>In this special episode of <em>Neuroscience Perspectives</em>, host </strong><a target="_blank" rel="noopener noreferrer nofollow" href="https://www.urmc.rochester.edu/people/112360965-john-j-foxe"><strong>John Foxe, PhD</strong></a><strong>, director of the </strong><a target="_blank" rel="noopener noreferrer nofollow" href="https://www.urmc.rochester.edu/del-monte-neuroscience.aspx"><strong>Del Monte Institute for Neuroscience at the University of Rochester</strong></a><strong>, sits down with </strong><a target="_blank" rel="noopener noreferrer nofollow" href="https://neurobiology.uchicago.edu/faculty/s-murray-sherman-phd"><strong>S. Murray Sherman, PhD</strong></a><strong>, Maurice Goldblatt Professor of Neurobiology at the </strong><a target="_blank" rel="noopener noreferrer nofollow" href="https://www.uchicago.edu/en"><strong>University of Chicago</strong></a><strong>, in Chicago at the annual </strong><a target="_blank" rel="noopener noreferrer nofollow" href="https://www.sfn.org/"><strong>Society for Neuroscience (SfN)</strong></a><strong> conference. Sherman is a neuroscientist known for his groundbreaking work on the thalamus. Dive into a compelling conversation that unravels how the thalamus plays a pivotal role as the brain's relay center, transforming sensory input into meaningful perceptions and actions. </strong></p><p>Discover how Dr. Sherman's research sheds light on the thalamus's intricate connections to cortical regions, revealing its role in shaping critical cognitive functions. From vision to decision-making, his work was integral in informing the understanding of the visual pathway from the retina through the thalamus to the cortex, and it also revealed other cortical areas organized in parallel to direct connections.</p><p>Learn how mentors and a bit of luck played critical roles in his journey, including Nobel laureates Richard Feynman, PhD, Roger Sperry, PhD, and Ray Guillery, PhD, who would become Sherman's longtime collaborator.</p><p><a target="_blank" rel="noopener noreferrer nofollow" href="https://www.sfn.org/-/media/SfN/Documents/About/History-of-Neuroscience/Volume-10/HON-V10_S_Murray_Sherman.pdf">Link to Sherman's SfN profile piece</a>.</p><p>Whether you're a neuroscientist or just interested in the brain —listen, learn, and subscribe to Neuroscience Perspectives today!</p>
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26 MIN