Sign In

MeSsy with Christina Applegate & Jamie Lynn Sigler

Wishbone Production

Details

On this podcast, Christina Applegate and Jamie Lynn Sigler get vulnerable about the curveballs that life can throw…theirs just happens to be MS. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life.

Recent Episodes

OCT 20, 2026
Christina Is Back (Part 2) with Dr. Marwa Kaisey
In part two of their conversation, Jamie and Christina are joined by Dr. Marwa Kaisey, an Associate Professor of Neurology at Cedars-Sinai in Los Angeles.
44 MIN
OCT 20, 2026
Christina Is Back (Part 1)
Christina is finally back! This week, she returns to MeSsy and joins Jamie to catch up on everything that’s been going on in her life over the past six months. Send us an email: https://www.messythepodcast.com/contact
35 MIN
OCT 13, 2026
Learning to Love Every Version of Yourself with Tiffani Thiessen
This week, Jamie is joined by Tiffani Thiessen. They talk about growing up in the spotlight, navigating rejection, embracing aging, and learning to love every version of yourself.
54 MIN
OCT 6, 2026
What If You’re Not Stuck, You’re Just in Between? with Emmanuelle Chriqui
This week, Jamie is joined by her friend, actress Emmanuelle Chriqui. They talk about grief, the friendships that carry us through hard times, getting older, learning to separate your self-worth from your career, and more.
57 MIN
SEP 29, 2026
I Don’t Have a Lot of Fight in Me Right Now
This week, Jamie reads listener emails and discusses parenting with MS, learning to embrace mobility aids, and navigating unsolicited advice and comparisons.
31 MIN