Hormones, Metabolism & You!
Hormones, Metabolism & You!

Hormones, Metabolism & You!

Cassie Smith

Overview
Episodes

Details

Your hormones control everything—from energy levels to weight, mood, and overall health. But understanding them shouldn’t feel like decoding a medical textbook. Welcome to Hormones, Metabolism & You!, the podcast where board-certified endocrinologist Dr. Cassie Smith breaks down the science behind your body’s most powerful regulators. Each week, Dr. Smith tackles the real questions about metabolism, weight management, thyroid health, menopause, PCOS, insulin resistance, and more—giving you clear, actionable insights to take charge of your health. Whether you’re struggling with stubborn weight, feeling fatigued, or just want to optimize your well-being, this podcast is your go-to resource for evidence-based advice, practical tips, and expert interviews. It’s time to understand your hormones, master your metabolism, and feel your best—because when your body is in balance, you thrive! 🎧 Subscribe now and start your journey to better health!

Recent Episodes

89: The FDA Finally Admits the Truth – The Shocking Correction That Changes Hormone Therapy Forever with Dr. Terri DeNeui
DEC 14, 2025
89: The FDA Finally Admits the Truth – The Shocking Correction That Changes Hormone Therapy Forever with Dr. Terri DeNeui
>>Join our FREE monthly Gut Health Webinar, so you can begin your Healing Journey.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://modernendocrinewellness.com/join-gut-health⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠<< What if the biggest breakthrough in women’s health this decade is the long overdue reversal of a warning that never should have existed in the first place? In this timely episode, Dr. Cassie Smith sits down with hormone expert and healthcare reform advocate Dr. Terri DeNeui, DNP, APRN, ACNP-BC to unpack the FDA’s landmark decision to remove the black box warning from estrogen containing HRT. For the first time in over twenty years, science and policy finally align, creating safer and more accessible options for millions of women. Dr. Cassie and Dr. Terri break down what the original research actually showed, how estrogen became unfairly feared, and why the updated guidelines are long overdue. They explore the benefits of estrogen, progesterone, and testosterone for women, clearing up misconceptions and highlighting the need for better hormone education among providers and patients. With clinical insights and decades of experience, this episode reveals the truth about hormone therapy, why women have suffered needlessly for two decades, and how the removal of the black box warning can reshape the future of women's health.   About the Guest Dr. Terri DeNeui, DNP, APRN, ACNP-BC is a board certified Adult Acute Care Nurse Practitioner, entrepreneur, Chief Science Officer, and leading voice in healthcare reform. She serves on the Executive Committee of the America First Policy Institute and the America First Women’s Initiative, contributing to national healthcare policy. A Summa Cum Laude graduate of the University of Texas at Arlington, Dr. DeNeui holds the Doctor of Nursing Practice degree. She is the Founder of EVEXIAS Medical Centers and EVEXIAS Health Solutions, and creator of the EvexiPEL Method of hormone optimization, used globally and supported by outcomes research. She is also lead teaching faculty for the A4M World Congress on Anti Aging Medicine. Her published work includes the peer reviewed article Best Practices in Care for the Menopausal Patient and the bestselling book Hormone Havoc: Dispelling the Myths and Misconceptions about Hormones in Women and Men.   Key Topics Covered What the FDA’s black box removal means for women How the Women’s Health Initiative was misinterpreted Estrogen’s role in brain, heart, bone, gut, metabolic, and vaginal health How fear based messaging led to unnecessary suffering Benefits and safety of micronized progesterone Why testosterone is essential for women’s mood, libido, muscle, and cognition Early testosterone decline and how it affects daily life Hormones, intimacy, and relationship well being Why hormone therapy requires gut health evaluation and individualized dosing Provider education gaps and self advocacy for women Recognizing hormone decline across the lifespan Why better policy and access to hormone therapy are urgently needed Connect with Dr. Terri DeNeui Instagram: https://www.instagram.com/drterrideneui/ Facebook: https://www.facebook.com/DrTerriDeNeui/LinkedIn: https://www.linkedin.com/in/terri-deneuiWebsite: https://www.evexias.comPodcast: https://podcasts.apple.com/us/podcast/the-dr-terri-show/id1757438909Email: [email protected] Phone: (214) 202-4727 📲 Follow Dr. Cassie Smith & Modern Endocrine 💻 Website:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.modern-endocrine.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ 📸 Instagram:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.instagram.com/modernendocrine_/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ 🌟 Facebook:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/ModernEndocrine⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ 📽️ YouTube:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/@modernendocrine⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ 🕹️ TikTok:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.tiktok.com/@modernendocrine?lang=en⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ 📰 Newsletter:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://linktr.ee/modernendocrine⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ➡️ Disclaimer:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.modernendocrineokc.com/disclaimer-6353⁠
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57 MIN
88: Why Your Thyroid Is in Crisis – The Hidden Triggers Driving Graves Disease with Dr. Eric Osansky
DEC 7, 2025
88: Why Your Thyroid Is in Crisis – The Hidden Triggers Driving Graves Disease with Dr. Eric Osansky
>>Join our FREE monthly Gut Health Webinar, so you can begin your Healing Journey.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://modernendocrinewellness.com/join-gut-health⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠<< What if the key to reversing Graves disease starts with uncovering the hidden triggers your thyroid has been reacting to all along? In this information rich episode, Dr. Cassie Smith sits down with functional medicine practitioner and thyroid expert Dr. Eric Osansky to break down the realities of Graves disease and hyperthyroidism. They explore why diagnosis is often delayed, what truly drives autoimmune thyroid conditions, and how gut health, nutrient deficiencies, infections, stress, and environmental toxins all influence thyroid function. Dr. Osansky also shares his personal remission journey and offers practical guidance, testing recommendations, and natural treatment options. This episode is essential for anyone navigating Graves disease, hyperthyroidism, or persistent thyroid symptoms and searching for a root cause approach. About the Guest Dr. Eric Osansky is a functional medicine practitioner with more than 15 years of clinical experience in chiropractic care, nutrition, and autoimmune thyroid health. After reversing his own Graves disease in 2009, he dedicated his career to helping others heal naturally. He is the author of Natural Treatment Solutions for Hyperthyroidism and Graves Disease, Hashimoto’s Triggers, and The Hyperthyroid Healing Diet, and hosts the Save My Thyroid podcast. He holds a Master’s degree in Human Nutrition and Functional Medicine and advanced certifications in nutrition and herbal therapy. Key Topics Covered How Graves disease differs from hypothyroidism and why hyperthyroidism is often misunderstood The environmental, immune, and lifestyle triggers that drive autoimmune thyroid disease Stress, infections, toxins, and overtraining as common contributors How gluten, corn, dairy, and high sodium intake influence leaky gut and autoimmunity The thyroid gut connection and how dysbiosis, H. pylori, and nutrient malabsorption affect thyroid function Essential nutrients for healthy thyroid hormone production and conversion The most important labs thyroid patients should request How H. pylori, viruses, mold, and stealth infections impact autoimmunity Conventional treatments including methimazole, PTU, beta blockers, and when they are necessary Natural therapies such as bugleweed, motherwort, lemon balm, selenium, and L carnitine The role of LDN and why results vary in Graves disease Why healing requires sleep, stress management, gut repair, movement, and nutrient optimization How to advocate for your health when providers overlook root causes Connect with Dr. Eric Osansky Facebook: https://www.facebook.com/NaturalThyroidTreatment/YouTube: https://www.youtube.com/@NaturalThyroidDoctorInstagram: https://www.instagram.com/drericosansky/Website: https://savemythyroid.com 📲 Follow Dr. Cassie Smith & Modern Endocrine 💻 Website:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.modern-endocrine.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ 📸 Instagram:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.instagram.com/modernendocrine_/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ 🌟 Facebook:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/ModernEndocrine⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ 📽️ YouTube:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/@modernendocrine⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ 🕹️ TikTok:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.tiktok.com/@modernendocrine?lang=en⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ 📰 Newsletter:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://linktr.ee/modernendocrine⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ➡️ Disclaimer:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.modernendocrineokc.com/disclaimer-6353⁠
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59 MIN
87: Stop Blaming Age – The Shocking Hidden Causes of Fatigue, Weight Gain, and Mood Swings with McCall McPherson and Dr. Tyna Moore
NOV 30, 2025
87: Stop Blaming Age – The Shocking Hidden Causes of Fatigue, Weight Gain, and Mood Swings with McCall McPherson and Dr. Tyna Moore
>>Join our FREE monthly Gut Health Webinar, so you can begin your Healing Journey.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://modernendocrinewellness.com/join-gut-health⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠<< What if the real answers to your midlife hormone struggles are not in a pill, but in understanding the deeper connections between your thyroid, metabolism, and the way your body changes over time? In this powerhouse mashup episode, Dr. Cassie Smith brings together two of the most outspoken and experienced voices in functional medicine: McCall McPherson, thyroid expert and founder of Modern Thyroid Clinic, and Dr. Tyna Moore, a naturopathic physician and metabolic health disruptor. Together, they unpack the complex hormonal shifts women experience—especially during perimenopause and menopause—and share real-world strategies to reclaim health, energy, and vitality. From GLP-1 medications to progesterone deficiency, thyroid misdiagnosis to strength training, this episode covers the most pressing questions women are asking today. You’ll hear personal insights, clinical wisdom, and evidence-based tools for navigating hormone changes, gut issues, inflammation, and mental health with clarity and confidence. 👤 About the Guests McCall McPherson is the founder of Modern Thyroid Clinic and Thyroid Nation, a TEDx speaker, physician assistant, and a thyroid warrior herself. Her mission is to end the suffering of millions with thyroid disorders through expert care, patient advocacy, and empowering education. Dr. Tyna Moore is a licensed Naturopathic Physician and Chiropractor specializing in resilient metabolic health, regenerative medicine, and clinical strength training. She's also the host of The Dr. Tyna Show and a strong advocate for women’s health and muscle-centric aging. 🔑 Key Topics Covered ✅ The truth about GLP-1s like semaglutide and tirzepatide—and what microdosing really means ✅ When to consider hormone therapy and why most women need progesterone earlier than expected ✅ Why muscle is your best metabolic and hormone-supporting organ ✅ The thyroid–estrogen connection and how hormone shifts during menopause impact thyroid function ✅ How GLP-1s can expose hidden dysfunctions like gut dysbiosis and low estrogen ✅ Why low progesterone may be behind your irritability, sleep issues, and anxiety ✅ The importance of comprehensive thyroid testing (FT3, FT4, RT3) and individualized care ✅ Gut–hormone–brain axis: how estrogen and thyroid hormones influence mood and digestion ✅ Alcohol and inflammation: the honest truth about even “just one glass” ✅ Empowering women to advocate for their health in a broken system ✅ The generational shift in how women approach midlife and aging 📲 Follow Dr. Cassie Smith & Modern Endocrine 💻 Website:⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.modern-endocrine.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠ 📸 Instagram:⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.instagram.com/modernendocrine_/⁠⁠⁠⁠⁠⁠⁠⁠⁠ 🌟 Facebook:⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/ModernEndocrine⁠⁠⁠⁠⁠⁠⁠⁠⁠ 📽️ YouTube:⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/@modernendocrine⁠⁠⁠⁠⁠⁠⁠⁠⁠ 🕹️ TikTok:⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.tiktok.com/@modernendocrine?lang=en⁠⁠⁠⁠⁠⁠⁠⁠⁠ 📰 Newsletter:⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://linktr.ee/modernendocrine⁠⁠⁠⁠⁠⁠⁠⁠⁠ ➡️ Disclaimer:⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://www.modernendocrineokc.com/disclaimer-6353⁠
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52 MIN
86: Your Brain Isn’t Broken – The Fastest Way to Rewire Anxiety and Hormones with Dr. Caroline Leaf
NOV 23, 2025
86: Your Brain Isn’t Broken – The Fastest Way to Rewire Anxiety and Hormones with Dr. Caroline Leaf
>>Join our FREE monthly Gut Health Webinar, so you can begin your Healing Journey.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠https://modernendocrinewellness.com/join-gut-health⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠<< What if the key to healing your hormones has been hidden in your thought patterns all along? In this transformational episode, Dr. Cassie Smith sits down with renowned clinical neuroscientist and communication pathologist Dr. Caroline Leaf to explore how mental health and hormonal health are deeply intertwined. They dive into the science of neuroplasticity—our brain’s ability to rewire itself—and how harnessing this power can help women break free from anxiety, depression, and hormonal imbalances. Dr. Leaf introduces her 5-step Neurocycle™ process, explains why anxiety and depression are not diseases but signals, and shows how rewiring our thought patterns can improve everything from thyroid function to weight loss. If you've ever struggled with chronic stress, burnout, mood swings, or stubborn hormone issues, this episode offers hope, science, and practical tools to help you heal from the inside out.   👤 About the Guest: Dr. Caroline Leaf is a clinical neuroscientist, communication pathologist, bestselling author of 19 books, and host of the award-winning podcast Cleaning Up the Mental Mess. With over 50 million downloads and a global following, Dr. Leaf is a pioneer in the field of mind-brain research and mental health. Her work bridges neuroscience, mental wellness, and functional healing through a holistic lens. 🔗 Website: www.drleaf.com 🎙️ Podcast: Cleaning Up the Mental Mess 📸 Instagram: @drcarolineleaf   🔑 Key Topics Covered: The critical difference between your mind and your brain—and why it matters for healing Understanding neuroplasticity and how thoughts physically rewire your brain and body Why anxiety, depression, and ADHD are not diseases but signals The Neurocycle™: A 5-step process to break toxic thinking and form healthier patterns The 63-day habit rewiring rule (not just 21!) How hormones respond to thought patterns and emotional states The mind-gut-hormone axis and why doctors often overlook it Why mental and emotional trauma can literally reshape your endocrine system The importance of self-directed mind management in chronic illness, burnout, and hormone recovery How to recognize when you're in the “dip” of transformation—and what to do about it 📲 Follow Dr. Cassie Smith & Modern Endocrine 💻 Website:⁠⁠⁠⁠⁠⁠⁠⁠ https://www.modern-endocrine.com/⁠⁠⁠⁠⁠⁠⁠⁠ 📸 Instagram:⁠⁠⁠⁠⁠⁠⁠⁠ https://www.instagram.com/modernendocrine_/⁠⁠⁠⁠⁠⁠⁠⁠ 🌟 Facebook:⁠⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/ModernEndocrine⁠⁠⁠⁠⁠⁠⁠⁠ 📽️ YouTube:⁠⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/@modernendocrine⁠⁠⁠⁠⁠⁠⁠⁠ 🕹️ TikTok:⁠⁠⁠⁠⁠⁠⁠⁠ https://www.tiktok.com/@modernendocrine?lang=en⁠⁠⁠⁠⁠⁠⁠⁠ 📰 Newsletter:⁠⁠⁠⁠⁠⁠⁠⁠ https://linktr.ee/modernendocrine⁠⁠⁠⁠⁠⁠⁠⁠ ➡️ Disclaimer:⁠⁠⁠⁠⁠⁠⁠⁠ https://www.modernendocrineokc.com/disclaimer-6353⁠
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53 MIN
85: What If Your Migraines Aren’t Just in Your Head? – The Hidden Root Causes with Dr. Meg Mill
NOV 16, 2025
85: What If Your Migraines Aren’t Just in Your Head? – The Hidden Root Causes with Dr. Meg Mill
>>Join our FREE monthly Gut Health Webinar, so you can begin your Healing Journey.⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠https://modernendocrinewellness.com/join-gut-health⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠<< Could your migraines be less about pain in your head—and more about hidden imbalances in your hormones, gut, and environment? In this episode of Hormones, Metabolism, and You, Dr. Cassie Smith sits down with functional medicine pharmacist Dr. Meg Mill to uncover the surprising root causes of chronic migraines—especially in women navigating hormonal shifts like menstruation, perimenopause, and menopause. Together, they explore how more than 50 potential triggers can fuel migraine symptoms, from dehydration and poor sleep to gut health issues, estrogen dominance, and histamine intolerance. Dr. Mill shares how functional medicine helps uncover these connections and provides a roadmap for lasting relief. They discuss the power of personalized migraine tracking, hormone and gut testing, and targeted protocols to reduce inflammation and rebalance the nervous system. Whether you’ve suffered for years or are newly struggling with hormone-driven headaches, this episode is a must-listen. 💡 Functional migraine solutions are within reach—no endless prescriptions required. 🔑 Key Topics Covered How hormonal shifts during perimenopause and menstruation trigger migraines Why there are 50+ potential migraine triggers—and how to uncover your unique mix Common food triggers: histamine, tyramine, nitrates, sulfites, MSG, and wine Why your environment, stress levels, and even your air quality can worsen migraines The link between estrogen dominance, progesterone deficiency, and mast cell activation The role of gut health, detoxification, and sleep in migraine prevention How histamine intolerance contributes to migraines, fatigue, anxiety, and skin issues The truth about low stomach acid, acid reflux, and poor nutrient absorption Personalized approaches vs. symptom suppression (why journaling matters) When to use testing like the DUTCH test or GI Map for hormones and gut health 👤 About the Guest: Dr. Meg Mill, PharmD, AFMCP Dr. Meg Mill is a functional medicine pharmacist, bestselling author, and host of A Little Bit Healthier podcast. With 20+ years of clinical experience, she helps women around the world resolve migraines, hormonal issues, and histamine-related symptoms. She's the founder of the Radiant Method, which empowers women to regain energy and clarity through root-cause healing. 📍 Learn more: www.megmill.com 🎧 Podcast: A Little Bit Healthier 📲 Follow Dr. Cassie Smith & Modern Endocrine 💻 Website:⁠⁠⁠⁠⁠⁠⁠ https://www.modern-endocrine.com/⁠⁠⁠⁠⁠⁠⁠ 📸 Instagram:⁠⁠⁠⁠⁠⁠⁠ https://www.instagram.com/modernendocrine_/⁠⁠⁠⁠⁠⁠⁠ 🌟 Facebook:⁠⁠⁠⁠⁠⁠⁠ https://www.facebook.com/ModernEndocrine⁠⁠⁠⁠⁠⁠⁠ 📽️ YouTube:⁠⁠⁠⁠⁠⁠⁠ https://www.youtube.com/@modernendocrine⁠⁠⁠⁠⁠⁠⁠ 🕹️ TikTok:⁠⁠⁠⁠⁠⁠⁠ https://www.tiktok.com/@modernendocrine?lang=en⁠⁠⁠⁠⁠⁠⁠ 📰 Newsletter:⁠⁠⁠⁠⁠⁠⁠ https://linktr.ee/modernendocrine⁠⁠⁠⁠⁠⁠⁠ ➡️ Disclaimer:⁠⁠⁠⁠⁠⁠⁠ https://www.modernendocrineokc.com/disclaimer-6353⁠
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44 MIN