Dennis McKenna joins 3L1T3 and Valerie Beltran to discuss the future of psychedelics, indigenous knowledge, and whether we are ready to bring these tools into mainstream culture without repeating the extractive patterns of the past. We explore the gap between good intentions and real reciprocity, what Western psychedelic enthusiasm is missing, and how community-based practice may matter more than clinical models alone.We also dive into the first biomedical study of ayahuasca with the UDV, how long-term members showed surprising changes in behavior and biology, and why the community structure may have played a larger role than the compound itself. Dennis talks about the work happening at the McKenna Academy, preserving Amazonian herbarium collections, digitizing ancestral plant knowledge, and the ESPD Symposia.This conversation calls out the cultural side of psychedelics, not just the science. If psychedelics are going to help, they must be integrated with wisdom, not just technology.Join our Patreon for the exclusive extended interview!Key PointsPsychedelics entered global awareness through indigenous stewardship, not Western inventionReciprocity requires more than money and acknowledgmentThe ESPD Symposia preserve ethnobotanical knowledge and make it publicEfforts to digitize herbarium collections in Peru before they are lostChapters00:00 Welcome to the season finale with Valerie01:10 Who Dennis McKenna is and why he still matters04:50 What still feels unresolved after 50 years06:15 Co-optation, capitalism, and indigenous knowledge09:00 The ESPD symposia and preserving ancestral knowledge12:40 Biognosis and digitizing Amazonian herbarium archives17:00 Why preserving knowledge matters more than artifacts18:35 The first biomedical study of ayahuasca with the UDV22:45 Behavioral change, alcoholism, and community support24:40 Serotonin transporter findings and biological mechanisms27:30 Neuroplasticity and long-term structural change31:00 Microdosing vs macro experiences33:20 Default mode network and stepping outside the self36:20 Separation from nature and cultural disconnection38:30 Technology, AI, and cultural fragmentation42:20 What real reciprocity might look like46:50 Avoiding cultural appropriation and extraction50:00 Psychedelics entering clinical models52:45 Mushrooms as ideal symbiotic partners56:00 Future of psychedelics in 10 years01:00:20 Ibogaine as global brain reset01:04:00 Evolution, partnership, and species symbiosis01:06:00 Closing thoughts Thanks to Dyl👽Alien for the music! Send us a text FiresideProject.orgDownload the app or text/call 62-FIRESIDEZendo ProjectOur listeners get 10% off the Zendo Project SIT Program with the code DIVERGENTS10Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the showSpecial Thanks to our Macrodosers, Super D and Mike on Patreon! https://linktr.ee/3L1T3Mod