The Moonshot Podcast

This episode of The Moonshot Podcast dives into the future of biology, exploring how to harness life's "tiny factories" to solve humanity's biggest challenges. Host Astro Teller sits down with Brad Zamft, CEO of Heritable Agriculture, to talk about programming plants to dramatically increase yield, pest, and drought resistance for a more sustainable food system. Next Astro speaks with Relly Brandman from project A-Life about unlocking the manufacturing power of biology, using AI to create a "virtual cell" that shifts biomanufacturing from slow trial-and-error to a predictable engineering discipline for making materials like medicines, fuels, and textiles. Hosted by Astro Teller, Captain of Moonshots, The Moonshot Podcast goes behind the scenes with creators and inventors trying to find radical solutions and breakthrough technologies to the world’s biggest problems. These are the untold stories of innovation from 15 years of Alphabet’s Moonshot Factory. The Moonshot Podcast is a Pique Action production for X, The Moonshot Factory, produced in association with Blanchard House. Learn more about your ad choices. Visit podcastchoices.com/adchoices

The Moonshot Podcast is back! In the season 2 premiere, X’s Captain of Moonshots Astro Teller explores how three X projects developed technology to transform the future of healthcare. He first sits down with Kathryn Zealand and Anna Roumiantseva from Skip to hear about how the world’s first “e-bike for walking” evolved from their team’s mobility moonshot at X. They recount how an early prototype of Skip’s powered pants helped carry a colleague to top of the Salesforce Tower, and share how the product has developed since spinning out into an independent company (Astro even tries a pair on for size to see their progress firsthand). Microelectronics expert Will Biederman then joins Astro for a conversation about the origins of Project Iris, a computerized contact lens designed to help measure diabetes risk, which laid the foundation for the continuous glucose monitors that millions of people use today. Finally, Astro chats with Verily CEO Stephen Gillet to hear about his mission to make precision healthcare accessible to anyone, anywhere, at any time. 0:00 - Intro 1:08 - Meet Kathryn Zealand and Anna Roumiantseva, Skip 1:57 - An “e-bike for walking” 2:35 - Why mobility needs a moonshot 3:42 - Limitations with current mobility solutions 6:19 - Criteria for the world’s first “movewear” 7:37 - Understanding the complexities of human motion 9:13 - How much weight Skip’s pants can carry 9:40 - Racing to the top of the Salesforce Tower 13:54 - Skip’s partnership with Arc’teryx 14:40 - The “kill criteria” for Skip’s moonshot 17:29 - Astro tries Skip’s pants on for size 18:55 - Meet Will Biederman, Project Iris 19:26 - Can a computerized contact lens help prevent diabetes? 20:19 - The potential worldwide impact of glucose monitoring 20:52 - Can tears help measure glucose? 22:50 - How to put a computer into a contact lens 24:11 - Project Iris’s early findings using glasses 25:20 - Fitting the “world’s smallest batteries” onto a contact lens 26:18 - A close-up view of the Project Iris contact lens 28:55 - How Project Iris transformed continuous glucose monitoring 31:18 - The origins of the Dexcom 7 32:08 - How glucose monitoring could lead to other health breakthroughs 32:55 - The future of everyday medical technologies 33:42 - Liftware’s “robot in a spoon” to counter tremors 34:16 - Meet Steven Gillett, Verily CEO 35:09 - Verily’s mission to democratize precision healthcare 36:30 - How Verily can aggregate a person’s entire medical history 39:05 - How Verily’s technology keeps private data secure 39:43 - Steve’s vision for how Verily can change the world 41:17 - What needs to happen in order to reach autonomous healthcare 42:27 - Conclusion – Hosted by Astro Teller, Captain of Moonshots, The Moonshot Podcast goes behind the scenes with creators and inventors trying to find radical solutions and breakthrough technologies to the world’s biggest problems. These are the untold stories of innovation from 16 years of Alphabet’s moonshot factory. The Moonshot Podcast is a Pique Action production for X, The Moonshot Factory, produced in association with Blanchard House. Learn more about your ad choices. Visit podcastchoices.com/adchoices

The Moonshot Podcast is back! The Moonshot Podcast chronicles the untold stories of innovation - both highs and lows - from inside Google’s Moonshot Factory. In Season 2, Captain of Moonshots Astro Teller sits down with a new crop of moonshot takers exploring the next frontiers in health, biology, computing and more. From energy kites and robotic pants, to sea fuel and digital immune systems, go behind the scenes with the inventors and creators working to turn "what if" into what’s next. Available from March 25, wherever you get your podcasts. Learn more about your ad choices. Visit podcastchoices.com/adchoices

In the ninth installment of the Moonshot Podcast Deep Dive series, Astro Teller and Emily Ma explore how to solve humanity’s food waste and hunger problems. They discuss how Project Delta built an “air traffic control” system for the world’s surplus food. They also discuss the origins of Chorus, X’s moonshot to give every object a voice which is now focused on optimizing global supply chains using advanced sensors and orchestration software. For more on the future of food waste, tune into Episode 6 of the Moonshot Podcast, “Trash to Treasure”: https://www.youtube.com/watch?v=WgRASA92Dco Video Segmentation 00:00 - Introduction 01:38 - The origins of Emily’s passion for food waste 04:07 - Why food waste is such a big problem 07:09 - How Emily wound up at X 10:24 - Google Glass in early food waste prototypes 12:06 - Emily’s “waste audit” sifting through physical trash 15:08 - How food is wasted in every phase of the production process 20:36 - An “air traffic control” system for the world’s surplus food 23:54 - How X’s food waste technology helped tackle that surplus 29:25 - What the team learned by working in the field 30:40 - Food waste “nodes” to reroute surplus food 33:34 - Applying X’s food waste technology outside the U.S. 35:41 - The team’s early vision for a supply chain moonshot - Chorus 39:56 - How Chorus evolved from the Delta team 41:26 - How Delta graduated to Google 45:06 - Emily’s fondest moonshot memories 46:54 - The importance of play when taking moonshots Learn more about your ad choices. Visit podcastchoices.com/adchoices

In the eighth installment of the Moonshot Podcast Deep Dive series, Astro Teller discusses the future of audio wearables with iyO Founder Jason Rugolo. They discuss the many unexpected use cases for machine-mediated hearing, what it was like to build the world’s first audio computer and how to make audio wearables “cool.” For more on the origins of iyO and the next generation of audio wearable technology, tune into Episode 9 of the Moonshot Podcast, “Supersenses”: https://www.youtube.com/watch?v=QlpF2QJNL5Y 00:00 - Introduction 02:17 - The first company Jason started at age 14 04:02 - How Jason came to X 06:40 - Jason’s earliest “fail fast” moonshot ideas 09:54 - The importance of being “the right amount too early” 12:45 - Radical idea for digital humans 14:59 - Early explorations into tele-video 18:49 - The original pitch for what became iyO 22:24 - Why designing great wearables for the ear is so hard 24:52 - Design considerations for audio wearables 29:41 - Making audio wearables “cool” 31:32 - The limitations of current in-ear devices 32:33 - The “superpowers” we’d have with machine-mediated hearing 35:30 - Building the first audio computer 36:30 - What the team’s first audio wearable looked like 38:01 - How audio wearables could help with translation 40:55 - The potential for wearables to protect from hearing loss 41:57 - The future of “hearing enhancement” apps 44:45 - The unexpected value of voice-to-audio interaction 48:34 - Astro’s “holy s**t” moment with audio wearables 52:26 - Why audio wearables need to change sound sources so quickly 55:47 - iyO’s public debut 57:23 - Surprising agentic AI use cases 58:50 - Physics conversations with the Einstein app using iyO 01:00:58 - Musical conversations with the iyO DJ app using iyO 01:01:51 - Jason’s hard-won lessons from taking moonshots Learn more about your ad choices. Visit podcastchoices.com/adchoices