<p>Explores the diagnostic and surgical algorithms for chronic refractory constipation. It clearly differentiates slow transit constipation (colonic inertia) from IBS-C utilizing the 5-day radiopaque marker study rule (retention of &gt;20% markers). The episode breaks down the latest pharmacotherapy, including secretagogues and PAMORAs for opioid-induced constipation, and thoroughly dissects the significant morbidity, incontinence risks, and patient selection criteria for a total abdominal colectomy with ileorectal anastomosis (TAC-IRA).</p><p><br></p>