<description>&lt;p class="MsoNormal"&gt;&lt;span style= "font-size: 12.0pt; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; color: #333333;"&gt; Dr. Suresh Durgam (Intra-Cellular Therapies, a Johnson &amp; Johnson Company, Bedminster, NJ) joins &lt;em&gt;AJP Audio&lt;/em&gt; to discuss &lt;a href= "https://psychiatryonline.org/doi/10.1176/appi.ajp.20250292" target="_blank" rel="noopener"&gt;a phase 3 randomized controlled trial&lt;/a&gt; looking at the use of the antipsychotic medication lumateperone as adjunctive to antidepressant therapy in the treatment of patients with major depressive disorder. Afterwards, &lt;em&gt;AJP&lt;/em&gt; Editor-in-Chief Dr. Ned Kalin discusses the rest of the December issue of the &lt;em&gt;Journal.&lt;/em&gt;&lt;/span&gt;&lt;/p&gt; &lt;ul&gt; &lt;li class="MsoNormal" style="background: white;"&gt;&lt;span style= "font-size: 12.0pt; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; color: black;"&gt; 00:48&lt;span style="mso-tab-count: 1;"&gt;  &lt;/span&gt; Durgam interview&lt;/span&gt;&lt;/li&gt; &lt;li class="MsoNormal" style="background: white;"&gt;&lt;span style= "font-size: 12.0pt; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; color: black;"&gt; 03:09&lt;span style="mso-tab-count: 1;"&gt;  &lt;/span&gt; Mechanism of action&lt;/span&gt;&lt;/li&gt; &lt;li class="MsoNormal" style="background: white;"&gt;&lt;span style= "font-size: 12.0pt; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; color: black;"&gt; 04:44&lt;span style="mso-tab-count: 1;"&gt;  &lt;/span&gt; Patient-reported outcomes&lt;/span&gt;&lt;/li&gt; &lt;li class="MsoNormal" style="background: white;"&gt;&lt;span style= "font-size: 12.0pt; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; color: black;"&gt; 06:31&lt;span style="mso-tab-count: 1;"&gt;  &lt;/span&gt; Immediate clinical implications&lt;/span&gt;&lt;/li&gt; &lt;li class="MsoNormal" style="background: white;"&gt;&lt;span style= "font-size: 12.0pt; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; color: black;"&gt; 07:32&lt;span style="mso-tab-count: 1;"&gt;  &lt;/span&gt; Limitations&lt;/span&gt;&lt;/li&gt; &lt;li class="MsoNormal" style="background: white;"&gt;&lt;span style= "font-size: 12.0pt; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; color: black;"&gt; 08:08&lt;span style="mso-tab-count: 1;"&gt;  &lt;/span&gt; Further research&lt;/span&gt;&lt;/li&gt; &lt;li class="MsoNormal" style="background: white;"&gt;&lt;span style= "font-size: 12.0pt; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; color: black;"&gt; 09:25&lt;span style="mso-tab-count: 1;"&gt;  &lt;/span&gt; Kalin interview&lt;/span&gt;&lt;/li&gt; &lt;li class="MsoNormal" style="background: white;"&gt;&lt;span style= "font-size: 12.0pt; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; color: black;"&gt; 09:38&lt;span style="mso-tab-count: 1;"&gt;  &lt;/span&gt; &lt;a href= "https://psychiatryonline.org/doi/10.1176/appi.ajp.20250292"&gt;Durgam et al.&lt;/a&gt;&lt;/span&gt;&lt;/li&gt; &lt;li class="MsoNormal" style="background: white;"&gt;&lt;span style= "font-size: 12.0pt; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; color: black;"&gt; 13:09&lt;span style="mso-tab-count: 1;"&gt;  &lt;/span&gt; &lt;a href= "https://doi.org/10.1176/appi.ajp.20241127"&gt;Lin et al.&lt;/a&gt;&lt;/span&gt;&lt;/li&gt; &lt;li class="MsoNormal" style="background: white;"&gt;&lt;span style= "font-size: 12.0pt; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; color: black;"&gt; 17:22&lt;span style="mso-tab-count: 1;"&gt;  &lt;/span&gt; &lt;a href= "https://doi.org/10.1176/appi.ajp.20240298"&gt;Brodsky et al.&lt;/a&gt;&lt;/span&gt;&lt;/li&gt; &lt;/ul&gt; &lt;p class="MsoNormal" style="background: white;"&gt;&lt;span style= "font-size: 12.0pt; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; color: black; mso-color-alt: windowtext;"&gt; &lt;a href= "https://psychiatryonline.org/pb-assets/podcasts/transcripts/AJP/AJP_Audio_Durgam_December_2025_transcript.pdf" target="_blank" rel="noopener"&gt;Transcript&lt;/a&gt;&lt;/span&gt;&lt;/p&gt; &lt;p class="MsoNormal" style="background: white;"&gt;&lt;span style= "font-size: 12.0pt; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin; color: #333333;"&gt; Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it.&lt;/span&gt;&lt;/p&gt; &lt;p class="MsoNormal" style="background: white;"&gt;&lt;span style= "font-size: 12.0pt; 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American Journal of Psychiatry Audio

American Journal of Psychiatry

December 2025: Adjunctive Lumateperone in Patients With Major Depressive Disorder: Results From a Randomized, Double-Blind, Phase 3 Trial

DEC 1, 202522 MIN
American Journal of Psychiatry Audio

December 2025: Adjunctive Lumateperone in Patients With Major Depressive Disorder: Results From a Randomized, Double-Blind, Phase 3 Trial

DEC 1, 202522 MIN

Description

Dr. Suresh Durgam (Intra-Cellular Therapies, a Johnson & Johnson Company, Bedminster, NJ) joins AJP Audio to discuss a phase 3 randomized controlled trial looking at the use of the antipsychotic medication lumateperone as adjunctive to antidepressant therapy in the treatment of patients with major depressive disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the December issue of the Journal.

  • 00:48 Durgam interview
  • 03:09 Mechanism of action
  • 04:44 Patient-reported outcomes
  • 06:31 Immediate clinical implications
  • 07:32 Limitations
  • 08:08 Further research
  • 09:25 Kalin interview
  • 09:38 Durgam et al.
  • 13:09 Lin et al.
  • 17:22 Brodsky et al.

Transcript

Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it.

Subscribe to the podcast here.

Listen to other podcasts produced by the American Psychiatric Association.

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How authors may submit their work.

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E-mail us at [email protected]